Abstract P150: Weight-Loss Diets and 2-Year Change of Circulating Amino Acids in Two Randomized Intervention Trials

Yan Zheng; Uta Ceglarek; Tao Huang; Lerong Li; Jennifer Rood; Donna Ryan; George Bray; Frank Sacks; Dan Schwarzfuchs; Joachim Thiery; Iris Shai; Lu Qi

doi:https://doi.org/10.1161/circ.131.suppl_1.p150

Abstract P150: Weight-Loss Diets and 2-Year Change of Circulating Amino Acids in Two Randomized Intervention Trials

Yan Zheng, Uta Ceglarek, Tao Huang, Lerong Li, Jennifer Rood, Donna Ryan, George Bray, Frank Sacks, Dan Schwarzfuchs, Joachim Thiery, Iris Shai, Lu Qi

Ben-Gurion University of the Negev

Research output: Contribution to journal › Meeting Abstract

Abstract

Background: Emerging evidence has related circulating amino acids to diabetes and cardiovascular risk. Little is known about how diet modifications affect circulating amino acids. The present study aimed to examine the effects of weight-loss diets on long-term changes in plasma amino acids, and their relations with weight loss and metabolic outcomes. Methods and Results: We repeatedly measured plasma amino acid profiles over 2 years among overweight or obese participants from two randomized dietary interventional weight-loss trials: 774 from the Preventing Overweight Using Novel Dietary Strategies trial (POUNDS LOST) and 318 from Dietary Intervention Randomized Controlled Trial (DIRECT). The plasma levels of most amino acids decreased from baseline during follow-up in both trials. In the POUNDS LOST trial, compared to the high-protein diets, the average-protein weight-loss diets showed a greater effect on decreasing plasma levels of a diabetes-associated branched-chain amino acid (BCAA) valine and another amino acid methyl-histidine at 6 months, independent of weight change (p

Original language	American English
Journal	Circulation
Volume	131
DOIs	https://doi.org/10.1161/circ.131.suppl_1.p150
State	Published - 4 Mar 2015

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@article{e63c5e25772c4eb197fe636fd4e6aebb,

title = "Abstract P150: Weight-Loss Diets and 2-Year Change of Circulating Amino Acids in Two Randomized Intervention Trials",

abstract = "Background: Emerging evidence has related circulating amino acids to diabetes and cardiovascular risk. Little is known about how diet modifications affect circulating amino acids. The present study aimed to examine the effects of weight-loss diets on long-term changes in plasma amino acids, and their relations with weight loss and metabolic outcomes. Methods and Results: We repeatedly measured plasma amino acid profiles over 2 years among overweight or obese participants from two randomized dietary interventional weight-loss trials: 774 from the Preventing Overweight Using Novel Dietary Strategies trial (POUNDS LOST) and 318 from Dietary Intervention Randomized Controlled Trial (DIRECT). The plasma levels of most amino acids decreased from baseline during follow-up in both trials. In the POUNDS LOST trial, compared to the high-protein diets, the average-protein weight-loss diets showed a greater effect on decreasing plasma levels of a diabetes-associated branched-chain amino acid (BCAA) valine and another amino acid methyl-histidine at 6 months, independent of weight change (p",

author = "Yan Zheng and Uta Ceglarek and Tao Huang and Lerong Li and Jennifer Rood and Donna Ryan and George Bray and Frank Sacks and Dan Schwarzfuchs and Joachim Thiery and Iris Shai and Lu Qi",

year = "2015",

month = mar,

day = "4",

doi = "https://doi.org/10.1161/circ.131.suppl_1.p150",

language = "American English",

volume = "131",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins Ltd.",

}

TY - JOUR

T1 - Abstract P150: Weight-Loss Diets and 2-Year Change of Circulating Amino Acids in Two Randomized Intervention Trials

AU - Zheng, Yan

AU - Ceglarek, Uta

AU - Huang, Tao

AU - Li, Lerong

AU - Rood, Jennifer

AU - Ryan, Donna

AU - Bray, George

AU - Sacks, Frank

AU - Schwarzfuchs, Dan

AU - Thiery, Joachim

AU - Shai, Iris

AU - Qi, Lu

PY - 2015/3/4

Y1 - 2015/3/4

N2 - Background: Emerging evidence has related circulating amino acids to diabetes and cardiovascular risk. Little is known about how diet modifications affect circulating amino acids. The present study aimed to examine the effects of weight-loss diets on long-term changes in plasma amino acids, and their relations with weight loss and metabolic outcomes. Methods and Results: We repeatedly measured plasma amino acid profiles over 2 years among overweight or obese participants from two randomized dietary interventional weight-loss trials: 774 from the Preventing Overweight Using Novel Dietary Strategies trial (POUNDS LOST) and 318 from Dietary Intervention Randomized Controlled Trial (DIRECT). The plasma levels of most amino acids decreased from baseline during follow-up in both trials. In the POUNDS LOST trial, compared to the high-protein diets, the average-protein weight-loss diets showed a greater effect on decreasing plasma levels of a diabetes-associated branched-chain amino acid (BCAA) valine and another amino acid methyl-histidine at 6 months, independent of weight change (p

AB - Background: Emerging evidence has related circulating amino acids to diabetes and cardiovascular risk. Little is known about how diet modifications affect circulating amino acids. The present study aimed to examine the effects of weight-loss diets on long-term changes in plasma amino acids, and their relations with weight loss and metabolic outcomes. Methods and Results: We repeatedly measured plasma amino acid profiles over 2 years among overweight or obese participants from two randomized dietary interventional weight-loss trials: 774 from the Preventing Overweight Using Novel Dietary Strategies trial (POUNDS LOST) and 318 from Dietary Intervention Randomized Controlled Trial (DIRECT). The plasma levels of most amino acids decreased from baseline during follow-up in both trials. In the POUNDS LOST trial, compared to the high-protein diets, the average-protein weight-loss diets showed a greater effect on decreasing plasma levels of a diabetes-associated branched-chain amino acid (BCAA) valine and another amino acid methyl-histidine at 6 months, independent of weight change (p

U2 - https://doi.org/10.1161/circ.131.suppl_1.p150

DO - https://doi.org/10.1161/circ.131.suppl_1.p150

M3 - Meeting Abstract

SN - 0009-7322

VL - 131

JO - Circulation

JF - Circulation

ER -

Abstract P150: Weight-Loss Diets and 2-Year Change of Circulating Amino Acids in Two Randomized Intervention Trials

Abstract

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