Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera from Individuals with Recent Seasonal Coronavirus Infection

Daniel Poston; Yiska Weisblum; Helen Wise; Kate Templeton; Sara Jenks; Theodora Hatziioannou; Paul Bieniasz

doi:10.1093/cid/ciaa1803

Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera from Individuals with Recent Seasonal Coronavirus Infection

Daniel Poston, Yiska Weisblum, Helen Wise, Kate Templeton, Sara Jenks, Theodora Hatziioannou, Paul Bieniasz

Research output: Contribution to journal › Article › peer-review

Abstract

Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Original language	English
Pages (from-to)	E1208-E1211
Journal	Clinical Infectious Diseases
Volume	73
Issue number	5
DOIs	https://doi.org/10.1093/cid/ciaa1803
State	Published - 1 Sep 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

COVID-19
SARS-CoV-2
antibodies
neutralization
seasonal coronavirus

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases

Access to Document

10.1093/cid/ciaa1803

Cite this

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title = "Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera from Individuals with Recent Seasonal Coronavirus Infection",

abstract = "Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.",

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author = "Daniel Poston and Yiska Weisblum and Helen Wise and Kate Templeton and Sara Jenks and Theodora Hatziioannou and Paul Bieniasz",

year = "2021",

month = sep,

day = "1",

doi = "10.1093/cid/ciaa1803",

language = "الإنجليزيّة",

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journal = "Clinical Infectious Diseases",

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T1 - Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera from Individuals with Recent Seasonal Coronavirus Infection

AU - Poston, Daniel

AU - Weisblum, Yiska

AU - Wise, Helen

AU - Templeton, Kate

AU - Jenks, Sara

AU - Hatziioannou, Theodora

AU - Bieniasz, Paul

PY - 2021/9/1

Y1 - 2021/9/1

N2 - Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

AB - Cross-reactive immune responses elicited by seasonal coronaviruses might affect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in prepandemic sera from patients with prior polymerase chain reaction scan-confirmed seasonal coronavirus infection. Although neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

KW - COVID-19

KW - SARS-CoV-2

KW - antibodies

KW - neutralization

KW - seasonal coronavirus

UR - http://www.scopus.com/inward/record.url?scp=85115907193&partnerID=8YFLogxK

U2 - 10.1093/cid/ciaa1803

DO - 10.1093/cid/ciaa1803

M3 - مقالة

C2 - 33270134

SN - 1058-4838

VL - 73

SP - E1208-E1211

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 5

ER -

Absence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Activity in Prepandemic Sera from Individuals with Recent Seasonal Coronavirus Infection

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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