ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences /631/92/72/1203 /631/92/555 article

Chethan D. Shanthamurthy; Prashant Jain; Sharon Yehuda; João T. Monteiro; Shani Leviatan Ben-Arye; Balamurugan Subramani; Bernd Lepenies; Vered Padler-Karavani; Raghavendra Kikkeri

doi:10.1038/s41598-018-24333-y

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences /631/92/72/1203 /631/92/555 article

Chethan D. Shanthamurthy, Prashant Jain, Sharon Yehuda, João T. Monteiro, Shani Leviatan Ben-Arye, Balamurugan Subramani, Bernd Lepenies, Vered Padler-Karavani, Raghavendra Kikkeri

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Understanding blood group antigen binding preferences for C-type lectin receptors holds promise for modulating immune responses, since several Gram-negative bacteria express blood group antigens as molecular mimicry to evade immune responses. Herein, we report the synthesis of ABO blood group antigen active tri and disaccharides to investigate the binding specificity with various C-type lectin receptors using glycan microarray. The results of binding preferences show that distinct glycosylation on the galactose and fucose motifs are key for C-type lectin receptor binding and that these interactions occur in a Ca²⁺-dependent fashion.

Original language	English
Article number	6603
Journal	Scientific Reports
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/s41598-018-24333-y
State	Published - 1 Dec 2018

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Shanthamurthy, C. D., Jain, P., Yehuda, S., Monteiro, J. T., Leviatan Ben-Arye, S., Subramani, B., Lepenies, B., Padler-Karavani, V., & Kikkeri, R. (2018). ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences /631/92/72/1203 /631/92/555 article. Scientific Reports, 8(1), Article 6603. https://doi.org/10.1038/s41598-018-24333-y

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title = "ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences /631/92/72/1203 /631/92/555 article",

abstract = "Understanding blood group antigen binding preferences for C-type lectin receptors holds promise for modulating immune responses, since several Gram-negative bacteria express blood group antigens as molecular mimicry to evade immune responses. Herein, we report the synthesis of ABO blood group antigen active tri and disaccharides to investigate the binding specificity with various C-type lectin receptors using glycan microarray. The results of binding preferences show that distinct glycosylation on the galactose and fucose motifs are key for C-type lectin receptor binding and that these interactions occur in a Ca2+-dependent fashion.",

author = "Shanthamurthy, \{Chethan D.\} and Prashant Jain and Sharon Yehuda and Monteiro, \{Jo{\~a}o T.\} and \{Leviatan Ben-Arye\}, Shani and Balamurugan Subramani and Bernd Lepenies and Vered Padler-Karavani and Raghavendra Kikkeri",

note = "Publisher Copyright: {\textcopyright} 2018 The Author(s).",

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doi = "10.1038/s41598-018-24333-y",

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Shanthamurthy, CD, Jain, P, Yehuda, S, Monteiro, JT, Leviatan Ben-Arye, S, Subramani, B, Lepenies, B, Padler-Karavani, V & Kikkeri, R 2018, 'ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences /631/92/72/1203 /631/92/555 article', Scientific Reports, vol. 8, no. 1, 6603. https://doi.org/10.1038/s41598-018-24333-y

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T1 - ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences /631/92/72/1203 /631/92/555 article

AU - Shanthamurthy, Chethan D.

AU - Jain, Prashant

AU - Yehuda, Sharon

AU - Monteiro, João T.

AU - Leviatan Ben-Arye, Shani

AU - Subramani, Balamurugan

AU - Lepenies, Bernd

AU - Padler-Karavani, Vered

AU - Kikkeri, Raghavendra

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Understanding blood group antigen binding preferences for C-type lectin receptors holds promise for modulating immune responses, since several Gram-negative bacteria express blood group antigens as molecular mimicry to evade immune responses. Herein, we report the synthesis of ABO blood group antigen active tri and disaccharides to investigate the binding specificity with various C-type lectin receptors using glycan microarray. The results of binding preferences show that distinct glycosylation on the galactose and fucose motifs are key for C-type lectin receptor binding and that these interactions occur in a Ca2+-dependent fashion.

AB - Understanding blood group antigen binding preferences for C-type lectin receptors holds promise for modulating immune responses, since several Gram-negative bacteria express blood group antigens as molecular mimicry to evade immune responses. Herein, we report the synthesis of ABO blood group antigen active tri and disaccharides to investigate the binding specificity with various C-type lectin receptors using glycan microarray. The results of binding preferences show that distinct glycosylation on the galactose and fucose motifs are key for C-type lectin receptor binding and that these interactions occur in a Ca2+-dependent fashion.

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U2 - 10.1038/s41598-018-24333-y

DO - 10.1038/s41598-018-24333-y

M3 - مقالة

SN - 2045-2322

VL - 8

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 6603

ER -

ABO Antigens Active Tri- and Disaccharides Microarray to Evaluate C-type Lectin Receptor Binding Preferences /631/92/72/1203 /631/92/555 article

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