Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

Hila Zigdon; Aviram Kogot-Levin; Joo-Won Park; Ruth Goldschmidt; Samuel Kelly; Alfred H., Jr. Merrill; Avigdor Scherz; Yael Pewzner-Jung; Ann Saada; Anthony H. Futerman

doi:10.1074/jbc.M112.402719

Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

Hila Zigdon, Aviram Kogot-Levin, Joo-Won Park, Ruth Goldschmidt, Samuel Kelly, Alfred H., Jr. Merrill, Avigdor Scherz, Yael Pewzner-Jung, Ann Saada, Anthony H. Futerman

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.

Original language	English
Pages (from-to)	4947-4956
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	288
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M112.402719
State	Published - 15 Feb 2013

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M112.402719

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Zigdon, H., Kogot-Levin, A., Park, J.-W., Goldschmidt, R., Kelly, S., Merrill, A. H. . J., Scherz, A., Pewzner-Jung, Y., Saada, A., & Futerman, A. H. (2013). Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. Journal of Biological Chemistry, 288(7), 4947-4956. https://doi.org/10.1074/jbc.M112.402719

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title = "Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain",

abstract = "Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.",

author = "Hila Zigdon and Aviram Kogot-Levin and Joo-Won Park and Ruth Goldschmidt and Samuel Kelly and Merrill, {Alfred H., Jr.} and Avigdor Scherz and Yael Pewzner-Jung and Ann Saada and Futerman, {Anthony H.}",

note = "National Institutes of Health [GM076217]; Israel Science Foundation [0888/11]; Minerva FoundationThis work was supported, in whole or in part, by National Institutes of Health Grant GM076217. This work was also supported by the Israel Science Foundation (0888/11) and the Minerva Foundation.",

year = "2013",

month = feb,

day = "15",

doi = "10.1074/jbc.M112.402719",

language = "الإنجليزيّة",

volume = "288",

pages = "4947--4956",

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T1 - Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

AU - Zigdon, Hila

AU - Kogot-Levin, Aviram

AU - Park, Joo-Won

AU - Goldschmidt, Ruth

AU - Kelly, Samuel

AU - Merrill, Alfred H., Jr.

AU - Scherz, Avigdor

AU - Pewzner-Jung, Yael

AU - Saada, Ann

AU - Futerman, Anthony H.

N1 - National Institutes of Health [GM076217]; Israel Science Foundation [0888/11]; Minerva FoundationThis work was supported, in whole or in part, by National Institutes of Health Grant GM076217. This work was also supported by the Israel Science Foundation (0888/11) and the Minerva Foundation.

PY - 2013/2/15

Y1 - 2013/2/15

N2 - Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.

AB - Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results: These mice have elevated sphinganine and altered N-acyl chain ceramides that disrupt mitochondrial function by modifying respiratory chain activity. Conclusion: Alteration of mitochondrial sphingolipids results in formation of reaction oxygen species in liver. Significance: Ceramides with defined acyl chains influence oxidative stress signaling pathways.

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U2 - 10.1074/jbc.M112.402719

DO - 10.1074/jbc.M112.402719

M3 - مقالة

SN - 0021-9258

VL - 288

SP - 4947

EP - 4956

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 7

ER -

Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain

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