Abstract
Gene amplification in the form of extrachromosomal DNA (ecDNA) or intrachromosomal homogenous staining regions (HSRs) is an emerging hallmark in cancer. Recent studies implicate abnormal nuclear structures in the biogenesis and evolution of amplified DNA. Here, we discuss how the interplay between aberrant nuclei and gene amplification drives cancer therapy resistance and metastasis.
| Original language | English |
|---|---|
| Pages (from-to) | 9-11 |
| Number of pages | 3 |
| Journal | TRENDS IN CANCER |
| Volume | 11 |
| Issue number | 1 |
| Early online date | 5 Oct 2024 |
| DOIs | |
| State | Published - Jan 2025 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- HSR
- chromosome bridges
- chromothripsis
- ecDNA
- gene amplification
- micronuclei
ASJC Scopus subject areas
- Oncology
- Cancer Research
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