A Vibrio T6SS-Mediated Lethality in an Aquatic Animal Model

Hadar Cohen, Chaya M. Fridman, Motti Gerlic, Dor Salomon

Research output: Contribution to journalArticlepeer-review

Abstract

Bacteria belonging to the genus Vibrio include many known and emerging pathogens. Horizontal gene transfer of pathogenicity islands is a major contributor to the emergence of new pathogenic Vibrio strains. Here, we use the brine shrimp Artemia salina as a model and show that the marine bacterium Vibrio proteolyticus uses a horizontally shared type VI secretion system, T6SS3, to intoxicate a eukaryotic host. Two T6SS3 effectors, which were previously shown to induce inflammasome-mediated pyroptotic cell death in mammalian phagocytic cells, contribute to this toxicity. Furthermore, we find a novel T6SS3 effector that also contributes to the lethality mediated by this system against Artemia salina. Therefore, our results reveal a T6SS that is shared among diverse vibrios and mediates host lethality, indicating that it can lead to the emergence of new pathogenic strains.

Original languageEnglish
JournalMicrobiology spectrum
Volume11
Issue number4
DOIs
StatePublished - Aug 2023

Keywords

  • Artemia
  • Vibrio proteolyticus
  • effector
  • effector functions
  • host-pathogen interaction
  • secretion
  • virulence

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases
  • Genetics
  • Physiology
  • Cell Biology
  • Ecology

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