TY - JOUR
T1 - A structural perspective on the evolution of viral/cellular macromolecular complexes within the arenaviridae family of viruses
AU - Diskin, Ron
N1 - Publisher Copyright: © 2023 Elsevier Ltd
PY - 2023/4
Y1 - 2023/4
N2 - Viruses are obligatory parasites that can replicate only inside host cells. Therefore, the evolutionary drive to enter cells is immense, leading to diversification in the cell-entry strategies of viruses. One of the most critical steps for cell entry is the recognition of the target cell, a process driven by the formation of viral/host macromolecular complexes. The accumulation of recent structural data for viruses within the arenaviridae family allows us to examine how different viral species from the same viral family utilize evolutionarily-related viral glycoproteins to engage with a variety of different cellular receptors. These structural data, compared to other viruses from the coronaviridae family, hint about possible routes that such viruses use for evolving new receptor-binding capabilities, allowing them to switch from one receptor to another.
AB - Viruses are obligatory parasites that can replicate only inside host cells. Therefore, the evolutionary drive to enter cells is immense, leading to diversification in the cell-entry strategies of viruses. One of the most critical steps for cell entry is the recognition of the target cell, a process driven by the formation of viral/host macromolecular complexes. The accumulation of recent structural data for viruses within the arenaviridae family allows us to examine how different viral species from the same viral family utilize evolutionarily-related viral glycoproteins to engage with a variety of different cellular receptors. These structural data, compared to other viruses from the coronaviridae family, hint about possible routes that such viruses use for evolving new receptor-binding capabilities, allowing them to switch from one receptor to another.
UR - http://www.scopus.com/inward/record.url?scp=85149070518&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.sbi.2023.102561
DO - https://doi.org/10.1016/j.sbi.2023.102561
M3 - مقالة مرجعية
C2 - 36857816
SN - 0959-440X
VL - 79
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
M1 - 102561
ER -