A stem cell approach to cure type 1 diabetes

Aharon Helman; Douglas A. Melton

doi:10.1101/cshperspect.a035741

A stem cell approach to cure type 1 diabetes

Research output: Contribution to journal › Article › peer-review

Abstract

Treatment of type 1 diabetes with insulin injection is expensive, complicated, and insuffi-cient. While cadaveric islet transplantations coupled with immunosuppressants can cure diabetes, the scarcity of acceptable islets is problematic. Developmental research on pancreas formation has informed in vitro differentiation of human pluripotent stem cells into functional islets. Although generating β cells from stem cells offers a potential cure for type 1 diabetes, several challenges remain, including protecting the cells from the immune system.

Original language	English
Article number	a035741
Pages (from-to)	1-10
Number of pages	10
Journal	Cold Spring Harbor perspectives in biology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1101/cshperspect.a035741
State	Published - 2021
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1101/cshperspect.a035741

Cite this

@article{586307d09a5247c8b724f634a9247669,

title = "A stem cell approach to cure type 1 diabetes",

abstract = "Treatment of type 1 diabetes with insulin injection is expensive, complicated, and insuffi-cient. While cadaveric islet transplantations coupled with immunosuppressants can cure diabetes, the scarcity of acceptable islets is problematic. Developmental research on pancreas formation has informed in vitro differentiation of human pluripotent stem cells into functional islets. Although generating β cells from stem cells offers a potential cure for type 1 diabetes, several challenges remain, including protecting the cells from the immune system.",

author = "Aharon Helman and Melton, \{Douglas A.\}",

year = "2021",

doi = "10.1101/cshperspect.a035741",

language = "الإنجليزيّة",

volume = "13",

pages = "1--10",

journal = "Cold Spring Harbor perspectives in biology",

issn = "1943-0264",

publisher = "Cold Spring Harbor Laboratory Press",

number = "1",

}

TY - JOUR

T1 - A stem cell approach to cure type 1 diabetes

AU - Helman, Aharon

AU - Melton, Douglas A.

PY - 2021

Y1 - 2021

N2 - Treatment of type 1 diabetes with insulin injection is expensive, complicated, and insuffi-cient. While cadaveric islet transplantations coupled with immunosuppressants can cure diabetes, the scarcity of acceptable islets is problematic. Developmental research on pancreas formation has informed in vitro differentiation of human pluripotent stem cells into functional islets. Although generating β cells from stem cells offers a potential cure for type 1 diabetes, several challenges remain, including protecting the cells from the immune system.

AB - Treatment of type 1 diabetes with insulin injection is expensive, complicated, and insuffi-cient. While cadaveric islet transplantations coupled with immunosuppressants can cure diabetes, the scarcity of acceptable islets is problematic. Developmental research on pancreas formation has informed in vitro differentiation of human pluripotent stem cells into functional islets. Although generating β cells from stem cells offers a potential cure for type 1 diabetes, several challenges remain, including protecting the cells from the immune system.

UR - http://www.scopus.com/inward/record.url?scp=85099427856&partnerID=8YFLogxK

U2 - 10.1101/cshperspect.a035741

DO - 10.1101/cshperspect.a035741

M3 - مقالة

C2 - 32122884

SN - 1943-0264

VL - 13

SP - 1

EP - 10

JO - Cold Spring Harbor perspectives in biology

JF - Cold Spring Harbor perspectives in biology

IS - 1

M1 - a035741

ER -

A stem cell approach to cure type 1 diabetes

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this