TY - JOUR
T1 - A Significant Expansion of Our Understanding of the Composition of the Human Microbiome
AU - Leviatan, Sigal
AU - Segal, Eran
N1 - Publisher Copyright: Copyright © 2019 Leviatan and Segal.
PY - 2019/1/29
Y1 - 2019/1/29
N2 - Shotgun sequencing of samples taken from the human microbiome often reveals only partial mapping of the sequenced metagenomic reads to existing reference genomes. Such partial mappability indicates that many genomes are missing in our reference genome set. This is particularly true for non-Western populations and for samples that do not originate from the gut. Pasolli et al. (E. Pasolli, F. Asnicar, S. Manara, M. Zolfo, et al., Cell, 2019, https://doi.org/10.1016/j.cell.2019.01.001) perform a grand effort to expand the reference set, and to better classify its members, revealing a wider pangenome of existing species as well as identifying new species of previously unknown taxonomic branches.
AB - Shotgun sequencing of samples taken from the human microbiome often reveals only partial mapping of the sequenced metagenomic reads to existing reference genomes. Such partial mappability indicates that many genomes are missing in our reference genome set. This is particularly true for non-Western populations and for samples that do not originate from the gut. Pasolli et al. (E. Pasolli, F. Asnicar, S. Manara, M. Zolfo, et al., Cell, 2019, https://doi.org/10.1016/j.cell.2019.01.001) perform a grand effort to expand the reference set, and to better classify its members, revealing a wider pangenome of existing species as well as identifying new species of previously unknown taxonomic branches.
UR - http://www.scopus.com/inward/record.url?scp=85090850738&partnerID=8YFLogxK
U2 - https://doi.org/10.1128/mSystems.00010-19
DO - https://doi.org/10.1128/mSystems.00010-19
M3 - كلمة العدد
SN - 2379-5077
VL - 4
JO - mSystems
JF - mSystems
IS - 1
M1 - e00010-19
ER -