A Significant Expansion of Our Understanding of the Composition of the Human Microbiome

Sigal Leviatan, Eran Segal

Research output: Contribution to journalEditorialpeer-review

Abstract

Shotgun sequencing of samples taken from the human microbiome often reveals only partial mapping of the sequenced metagenomic reads to existing reference genomes. Such partial mappability indicates that many genomes are missing in our reference genome set. This is particularly true for non-Western populations and for samples that do not originate from the gut. Pasolli et al. (E. Pasolli, F. Asnicar, S. Manara, M. Zolfo, et al., Cell, 2019, https://doi.org/10.1016/j.cell.2019.01.001) perform a grand effort to expand the reference set, and to better classify its members, revealing a wider pangenome of existing species as well as identifying new species of previously unknown taxonomic branches.

Original languageEnglish
Article numbere00010-19
Number of pages3
JournalmSystems
Volume4
Issue number1
DOIs
StatePublished - 29 Jan 2019

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