A role of disordered domains in regulating protein oligomerization and stability

Ofrah Faust, Lavi Bigman, Assaf Friedler

Research output: Contribution to journalArticlepeer-review

Abstract

Intrinsically disordered proteins (IDPs) or regions (IDRs) in proteins hold many functions but their biological roles are still not fully understood. Here we describe a new role of such regions. Using the HIV-1 Rev protein, we show that disordered domains have a role in maintaining the correct oligomeric state and the thermodynamic stability of proteins.

Original languageAmerican English
Pages (from-to)10797-10800
Number of pages4
JournalChemical Communications
Volume50
Issue number74
DOIs
StatePublished - 18 Aug 2014

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • General Chemistry
  • Ceramics and Composites
  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Catalysis

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