A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

Nasa Sinnott-Armstrong; Isabel S. Sousa; Samantha Laber; Elizabeth Rendina-Ruedy; Simon E. Nitter Dankel; Teresa Ferreira; Gunnar Mellgren; David Karasik; Manuel Rivas; Jonathan Pritchard; Anyonya R. Guntur; Roger D. Cox; Cecilia M. Lindgren; Hans Hauner; Richard Sallari; Clifford J. Rosen; Yi Hsiang Hsu; Eric S. Lander; Douglas P. Kiel; Melina Claussnitzer

doi:https://doi.org/10.1016/j.cmet.2021.01.001

A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

Nasa Sinnott-Armstrong, Isabel S. Sousa, Samantha Laber, Elizabeth Rendina-Ruedy, Simon E. Nitter Dankel, Teresa Ferreira, Gunnar Mellgren, David Karasik, Manuel Rivas, Jonathan Pritchard, Anyonya R. Guntur, Roger D. Cox, Cecilia M. Lindgren, Hans Hauner, Richard Sallari, Clifford J. Rosen, Yi Hsiang Hsu, Eric S. Lander, Douglas P. Kiel, Melina Claussnitzer

Bar-Ilan University - Azrieli Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture.

Original language	English
Pages (from-to)	615-628.e13
Journal	Cell Metabolism
Volume	33
Issue number	3
DOIs	https://doi.org/10.1016/j.cmet.2021.01.001
State	Published - 2 Mar 2021

Keywords

CRISPR-Cas9 variant editing
osteoblast and adipocyte metabolism
pleiotropy of type 2 diabetes and bone mineral density
regulatory genomics
variant-to-function study

All Science Journal Classification (ASJC) codes

Molecular Biology
Physiology
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1016/j.cmet.2021.01.001

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Sinnott-Armstrong, N., Sousa, I. S., Laber, S., Rendina-Ruedy, E., Nitter Dankel, S. E., Ferreira, T., Mellgren, G., Karasik, D., Rivas, M., Pritchard, J., Guntur, A. R., Cox, R. D., Lindgren, C. M., Hauner, H., Sallari, R., Rosen, C. J., Hsu, Y. H., Lander, E. S., Kiel, D. P., & Claussnitzer, M. (2021). A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density. Cell Metabolism, 33(3), 615-628.e13. https://doi.org/10.1016/j.cmet.2021.01.001

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title = "A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density",

abstract = "Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture.",

keywords = "CRISPR-Cas9 variant editing, osteoblast and adipocyte metabolism, pleiotropy of type 2 diabetes and bone mineral density, regulatory genomics, variant-to-function study",

author = "Nasa Sinnott-Armstrong and Sousa, {Isabel S.} and Samantha Laber and Elizabeth Rendina-Ruedy and {Nitter Dankel}, {Simon E.} and Teresa Ferreira and Gunnar Mellgren and David Karasik and Manuel Rivas and Jonathan Pritchard and Guntur, {Anyonya R.} and Cox, {Roger D.} and Lindgren, {Cecilia M.} and Hans Hauner and Richard Sallari and Rosen, {Clifford J.} and Hsu, {Yi Hsiang} and Lander, {Eric S.} and Kiel, {Douglas P.} and Melina Claussnitzer",

note = "Publisher Copyright: {\textcopyright} 2021",

year = "2021",

month = mar,

day = "2",

doi = "https://doi.org/10.1016/j.cmet.2021.01.001",

language = "الإنجليزيّة",

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Sinnott-Armstrong, N, Sousa, IS, Laber, S, Rendina-Ruedy, E, Nitter Dankel, SE, Ferreira, T, Mellgren, G, Karasik, D, Rivas, M, Pritchard, J, Guntur, AR, Cox, RD, Lindgren, CM, Hauner, H, Sallari, R, Rosen, CJ, Hsu, YH, Lander, ES, Kiel, DP & Claussnitzer, M 2021, 'A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density', Cell Metabolism, vol. 33, no. 3, pp. 615-628.e13. https://doi.org/10.1016/j.cmet.2021.01.001

TY - JOUR

T1 - A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

AU - Sinnott-Armstrong, Nasa

AU - Sousa, Isabel S.

AU - Laber, Samantha

AU - Rendina-Ruedy, Elizabeth

AU - Nitter Dankel, Simon E.

AU - Ferreira, Teresa

AU - Mellgren, Gunnar

AU - Karasik, David

AU - Rivas, Manuel

AU - Pritchard, Jonathan

AU - Guntur, Anyonya R.

AU - Cox, Roger D.

AU - Lindgren, Cecilia M.

AU - Hauner, Hans

AU - Sallari, Richard

AU - Rosen, Clifford J.

AU - Hsu, Yi Hsiang

AU - Lander, Eric S.

AU - Kiel, Douglas P.

AU - Claussnitzer, Melina

PY - 2021/3/2

Y1 - 2021/3/2

N2 - Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture.

AB - Nasa Sinnott-Armstrong and colleagues identify a pleiotropic risk locus at 3q21 that is associated with type 2 diabetes (T2D) and greater bone mineral density (BMD) and its associated cell-autonomous mechanisms in adipocytes and osteoblasts. Together, these findings provide a possible explanation for the perplexing finding that individuals with T2D have higher BMD but greater susceptibility to bone fracture.

KW - CRISPR-Cas9 variant editing

KW - osteoblast and adipocyte metabolism

KW - pleiotropy of type 2 diabetes and bone mineral density

KW - regulatory genomics

KW - variant-to-function study

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U2 - https://doi.org/10.1016/j.cmet.2021.01.001

DO - https://doi.org/10.1016/j.cmet.2021.01.001

M3 - مقالة

C2 - 33513366

SN - 1550-4131

VL - 33

SP - 615-628.e13

JO - Cell Metabolism

JF - Cell Metabolism

IS - 3

ER -

A regulatory variant at 3q21.1 confers an increased pleiotropic risk for hyperglycemia and altered bone mineral density

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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