Abstract
Methylphenidate affects state-anxiety in ADHD patients. The current study examines the effect of Methylphenidate on state-anxiety in healthy subjects. In a cross-over, randomized, controlled, double-blind study, 36 healthy subjects received either Methylphenidate or placebo. As a group, no change in state-anxiety was detected with Methylphenidate. However, participants reporting higher anxiety levels experienced a significant and specific state-anxiety reduction following Methylphenidate. Moreover, a strong negative correlation was found between the initial-level of anxiety and net-change in state-anxiety. These changes were unrelated to self-perceived attention levels. Our results point to the state-dependent effects of Methylphenidate on anxiety.
Original language | English |
---|---|
Pages (from-to) | 232-235 |
Number of pages | 4 |
Journal | Psychiatry Research |
Volume | 241 |
DOIs | |
State | Published - 30 Jul 2016 |
Keywords
- ADHD
- Attention
- Cognitive enhancer
All Science Journal Classification (ASJC) codes
- Psychiatry and Mental health
- Biological Psychiatry