A phenomenological model for chemico-mechanically induced cell shape changes during migration and cell-cell contacts

F. J. Vermolen, A. Gefen

Research output: Contribution to journalArticlepeer-review

Abstract

A phenomenological model for the evolution of shape transition of cells is considered. These transitions are determined by the emission of growth-factors, as well as mechanical interaction if cells are subjected to hard impingement. The originality of this model necessitates a formal treatment of the mathematical model, as well as the presentation of elementary cases in order to illustrate the consistence of the model. We will also show some small-scale relevant applications.

Original languageEnglish
Pages (from-to)301-323
Number of pages23
JournalBiomechanics and Modeling in Mechanobiology
Volume12
Issue number2
DOIs
StatePublished - Apr 2013

Keywords

  • Cell deformation
  • Chemotaxis
  • Phenomenological modeling

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Modelling and Simulation
  • Mechanical Engineering

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