A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen

Benyamin Rosental; Uzi Hadad; Michael Brusilovsky; Kerry S. Campbell; Angel Porgador

doi:10.4161/onci.19366

A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen

Benyamin Rosental, Uzi Hadad, Michael Brusilovsky, Kerry S. Campbell, Angel Porgador

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.

Original language	American English
Pages (from-to)	572-574
Number of pages	3
Journal	OncoImmunology
Volume	1
Issue number	4
DOIs	https://doi.org/10.4161/onci.19366
State	Published - 2 Nov 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

ITIM
Inhibitory ligand
NCR
NK cells
NKp44
PCNA

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Oncology

Access to Document

10.4161/onci.19366

Cite this

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abstract = "We recently reported proliferating cell nuclear antigen (PCNA) as a ligand for the NK cell activating receptor, NKp44, which unexpectedly triggers inhibition. The recognition of nuclear proteins such as PCNA, by related NK cell receptors has been reported. Widespread upregulation of PCNA in tumor cells may therefore promote immune evasion.",

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AU - Campbell, Kerry S.

AU - Porgador, Angel

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A novel mechanism for cancer cells to evade immune attack by NK cells: The interaction between NKp44 and proliferating cell nuclear antigen

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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