A metabolic link between the urea cycle and cancer cell proliferation

Sandesh C. S. Nagamani; Ayelet Erez

doi:10.1080/23723556.2015.1127314

A metabolic link between the urea cycle and cancer cell proliferation

Sandesh C. S. Nagamani
, Ayelet Erez

Department of Immunology and Regenerative Biology

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.

Original language	English
Article number	1127314
Number of pages	3
Journal	Molecular & cellular oncology
Volume	3
Issue number	2
DOIs	https://doi.org/10.1080/23723556.2015.1127314
State	Published Online - 4 Apr 2016

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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title = "A metabolic link between the urea cycle and cancer cell proliferation",

abstract = "Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.",

author = "Nagamani, \{Sandesh C. S.\} and Ayelet Erez",

note = "SCSN is supported by Baylor College of Medicine IDDRC Grant (1 U54 HD083092) and by the Doris Duke Charitable Foundation (DDCF 2013095). AE is incumbent of the Leah Omenn Career Development Chair and is supported by research grants from the European research program (CIG618113, ERC614204), the Israel Science Foundation (1343/13; 1952/13), and from the Minerva grant award (711730). AE received additional support from the Adelis Foundation, the Henry S. and Anne S. Reich Research Fund, the Dukler Fund for Cancer Research, the Paul Sparr Foundation, the Saul and Theresa Esman Foundation, from Joseph Piko Baruch, and from the estate of Fannie Sherr.",

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doi = "10.1080/23723556.2015.1127314",

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AU - Erez, Ayelet

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N2 - Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.

AB - Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.

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JO - Molecular & cellular oncology

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A metabolic link between the urea cycle and cancer cell proliferation

Abstract

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