TY - JOUR
T1 - A metabolic link between the urea cycle and cancer cell proliferation
AU - Nagamani, Sandesh C. S.
AU - Erez, Ayelet
N1 - SCSN is supported by Baylor College of Medicine IDDRC Grant (1 U54 HD083092) and by the Doris Duke Charitable Foundation (DDCF 2013095). AE is incumbent of the Leah Omenn Career Development Chair and is supported by research grants from the European research program (CIG618113, ERC614204), the Israel Science Foundation (1343/13; 1952/13), and from the Minerva grant award (711730). AE received additional support from the Adelis Foundation, the Henry S. and Anne S. Reich Research Fund, the Dukler Fund for Cancer Research, the Paul Sparr Foundation, the Saul and Theresa Esman Foundation, from Joseph Piko Baruch, and from the estate of Fannie Sherr.
PY - 2016/4/4
Y1 - 2016/4/4
N2 - Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.
AB - Clinical observations in citrullinemia type I, an inborn error of metabolism, led us to explore the benefits of somatic ASS1 silencing in cancer. We found that downregulation of ASS1 results in preferential utilization of its substrate, aspartate, for pyrimidine synthesis to support cell proliferation. Reducing aspartate availability for pyrimidine synthesis restricted cancerous proliferation.
UR - http://www.scopus.com/inward/record.url?scp=85043309455&partnerID=8YFLogxK
U2 - 10.1080/23723556.2015.1127314
DO - 10.1080/23723556.2015.1127314
M3 - مقالة
SN - 2372-3556
VL - 3
JO - Molecular & cellular oncology
JF - Molecular & cellular oncology
IS - 2
M1 - 1127314
ER -