A macrocyclic 19F-MR based probe for Mn2 + sensing

Anindita Sarkar; Inbal E. Biton; Michal Neeman; Ankona Datta

doi:10.1016/j.inoche.2017.02.008

A macrocyclic ¹⁹F-MR based probe for Mn^{2 +} sensing

Anindita Sarkar, Inbal E. Biton, Michal Neeman, Ankona Datta

Department of Immunology and Regenerative Biology

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

We report a novel fluorinated aza-macrocycle that affords a linear increase in longitudinal and transverse ¹⁹F NMR relaxation rates between 100 μM to 1 mM Mn^{2 +} concentrations. The linear response which is unaffected in the presence of other biologically relevant metal ions and ¹⁹F-MR phantom images of macrocycle solutions in presence of Mn^{2 +} indicate the potential applicability of the probe as a ¹⁹F-MR based Mn^{2 +} sensor.

Original language	English
Pages (from-to)	21-24
Number of pages	4
Journal	Inorganic Chemistry Communications
Volume	78
DOIs	https://doi.org/10.1016/j.inoche.2017.02.008
State	Published - 1 Apr 2017

All Science Journal Classification (ASJC) codes

Materials Chemistry
Inorganic Chemistry
Physical and Theoretical Chemistry

Access to Document

10.1016/j.inoche.2017.02.008

Cite this

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title = "A macrocyclic 19F-MR based probe for Mn2 + sensing",

abstract = "We report a novel fluorinated aza-macrocycle that affords a linear increase in longitudinal and transverse 19F NMR relaxation rates between 100 μM to 1 mM Mn2 + concentrations. The linear response which is unaffected in the presence of other biologically relevant metal ions and 19F-MR phantom images of macrocycle solutions in presence of Mn2 + indicate the potential applicability of the probe as a 19F-MR based Mn2 + sensor.",

author = "Anindita Sarkar and Biton, {Inbal E.} and Michal Neeman and Ankona Datta",

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AU - Biton, Inbal E.

AU - Neeman, Michal

AU - Datta, Ankona

PY - 2017/4/1

Y1 - 2017/4/1

N2 - We report a novel fluorinated aza-macrocycle that affords a linear increase in longitudinal and transverse 19F NMR relaxation rates between 100 μM to 1 mM Mn2 + concentrations. The linear response which is unaffected in the presence of other biologically relevant metal ions and 19F-MR phantom images of macrocycle solutions in presence of Mn2 + indicate the potential applicability of the probe as a 19F-MR based Mn2 + sensor.

AB - We report a novel fluorinated aza-macrocycle that affords a linear increase in longitudinal and transverse 19F NMR relaxation rates between 100 μM to 1 mM Mn2 + concentrations. The linear response which is unaffected in the presence of other biologically relevant metal ions and 19F-MR phantom images of macrocycle solutions in presence of Mn2 + indicate the potential applicability of the probe as a 19F-MR based Mn2 + sensor.

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VL - 78

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EP - 24

JO - Inorganic Chemistry Communications

JF - Inorganic Chemistry Communications