A heritable subset of the core rumen microbiome dictates dairy cow productivity and emissions

R. John Wallace, Goor Sasson, Philip C. Garnsworthy, Ilma Tapio, Emma Gregson, Paolo Bani, Pekka Huhtanen, Ali R. Bayat, Francesco Strozzi, Filippo Biscarini, Timothy J. Snelling, Neil Saunders, Sarah L. Potterton, James Craigon, Andrea Minuti, Erminio Trevisi, Maria L. Callegari, Fiorenzo Piccioli Cappelli, Edward H. Cabezas-Garcia, Johanna VilkkiCesar Pinares-Patino, Kateřina O. Fliegerová, Jakub Mrázek, Hana Sechovcová, Jan Kopečný, Aurélie Bonin, Frédéric Boyer, Pierre Taberlet, Fotini Kokou, Eran Halperin, John L. Williams, Kevin J. Shingfield, Itzhak Mizrahi

Research output: Contribution to journalArticlepeer-review

Abstract

A 1000-cow study across four European countries was undertaken to understand to what extent ruminant microbiomes can be controlled by the host animal and to identify characteristics of the host rumen microbiome axis that determine productivity and methane emissions. A core rumen microbiome, phylogenetically linked and with a preserved hierarchical structure, was identified. A 39-member subset of the core formed hubs in co-occurrence networks linking microbiome structure to host genetics and phenotype (methane emissions, rumen and blood metabolites, and milk production efficiency). These phenotypes can be predicted from the core microbiome using machine learning algorithms. The heritable core microbes, therefore, present primary targets for rumen manipulation toward sustainable and environmentally friendly agriculture.

Original languageEnglish
Article numbereaav8391
JournalScience Advances
Volume5
Issue number7
DOIs
StatePublished - 1 Jan 2019

All Science Journal Classification (ASJC) codes

  • General

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