A Glowing Trajectory between Bio- and Chemiluminescence: From Luciferin-Based Probes to Triggerable Dioxetanes

Nir Hananya; Doron Shabat

doi:https://doi.org/10.1002/anie.201706969

A Glowing Trajectory between Bio- and Chemiluminescence: From Luciferin-Based Probes to Triggerable Dioxetanes

Nir Hananya, Doron Shabat

School of Chemistry

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

Abstract

Bioluminescent and chemiluminescent probes are widely used for noninvasive imaging applications because of their high sensitivity and the simplicity of the equipment required to perform the measurement. Synthetic luciferin-analogue probes with in vivo imaging performance better than that of luciferin are now available. In addition, caged luciferin-based bioluminogenic probes have been emerged as a general tool for the visualization of different enzymes and analytes in vivo. Recent discoveries have led to development of highly efficient chemiluminescent probes that are extremely bright under physiological conditions. As discussed in this Minireview, chemiluminescence is ready to realize its potential as a valuable tool for imaging in living systems.

Original language	English
Pages (from-to)	16454-16463
Number of pages	10
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	52
DOIs	https://doi.org/10.1002/anie.201706969
State	Published - 22 Dec 2017

Keywords

bioluminescence
chemiluminescence
dioxetanes
luciferin
optical imaging

All Science Journal Classification (ASJC) codes

General Chemistry
Catalysis

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https://doi.org/10.1002/anie.201706969

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title = "A Glowing Trajectory between Bio- and Chemiluminescence: From Luciferin-Based Probes to Triggerable Dioxetanes",

abstract = "Bioluminescent and chemiluminescent probes are widely used for noninvasive imaging applications because of their high sensitivity and the simplicity of the equipment required to perform the measurement. Synthetic luciferin-analogue probes with in vivo imaging performance better than that of luciferin are now available. In addition, caged luciferin-based bioluminogenic probes have been emerged as a general tool for the visualization of different enzymes and analytes in vivo. Recent discoveries have led to development of highly efficient chemiluminescent probes that are extremely bright under physiological conditions. As discussed in this Minireview, chemiluminescence is ready to realize its potential as a valuable tool for imaging in living systems.",

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doi = "https://doi.org/10.1002/anie.201706969",

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AU - Shabat, Doron

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Y1 - 2017/12/22

N2 - Bioluminescent and chemiluminescent probes are widely used for noninvasive imaging applications because of their high sensitivity and the simplicity of the equipment required to perform the measurement. Synthetic luciferin-analogue probes with in vivo imaging performance better than that of luciferin are now available. In addition, caged luciferin-based bioluminogenic probes have been emerged as a general tool for the visualization of different enzymes and analytes in vivo. Recent discoveries have led to development of highly efficient chemiluminescent probes that are extremely bright under physiological conditions. As discussed in this Minireview, chemiluminescence is ready to realize its potential as a valuable tool for imaging in living systems.

AB - Bioluminescent and chemiluminescent probes are widely used for noninvasive imaging applications because of their high sensitivity and the simplicity of the equipment required to perform the measurement. Synthetic luciferin-analogue probes with in vivo imaging performance better than that of luciferin are now available. In addition, caged luciferin-based bioluminogenic probes have been emerged as a general tool for the visualization of different enzymes and analytes in vivo. Recent discoveries have led to development of highly efficient chemiluminescent probes that are extremely bright under physiological conditions. As discussed in this Minireview, chemiluminescence is ready to realize its potential as a valuable tool for imaging in living systems.

KW - bioluminescence

KW - chemiluminescence

KW - dioxetanes

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KW - optical imaging

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M3 - مقالة مرجعية

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SN - 1433-7851

VL - 56

SP - 16454

EP - 16463

JO - Angewandte Chemie - International Edition

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A Glowing Trajectory between Bio- and Chemiluminescence: From Luciferin-Based Probes to Triggerable Dioxetanes

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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