TY - JOUR
T1 - A dual program for translation regulation in cellular proliferation and differentiation.
AU - Gingold, Hila
AU - Tehler, Disa
AU - Christoffersen, Nanna R.
AU - Nielsen, Morten M.
AU - Asmar, Fazila
AU - Kooistra, Susanne M.
AU - Christophersen, Nicolaj S.
AU - Christensen, Lise Lotte
AU - Borre, Michael
AU - Sørensen, Karina D.
AU - Andersen, Lars D.
AU - Andersen, Claus L.
AU - Hulleman, Esther
AU - Wurdinger, Tom
AU - Ralfkiær, Elisabeth
AU - Helin, Kristian
AU - Grønbæk, Kirsten
AU - Orntoft, Torben
AU - Waszak, Sebastian M.
AU - Dahan, Orna
AU - Pedersen, Jakob Skou
AU - Lund, Anders H.
AU - Pilpel, Yitzhak
AU - Kooistra, SM
AU - Christophersen, NS
AU - Sorensen, KD
AU - Gronbaek, K
AU - Omtoft, T
AU - Pedersen, JS
N1 - European Research Council (ERC) grant; Danish National Advanced Technology Foundation; Danish Council for Strategic Research; Danish Council for Independent Research; Novo Nordisk Foundation; Lundbeck Foundation; Danish Cancer Society; Netherlands Organisation for scientific research (NWO); Danish National Research Foundation [DNRF82] Work in the authors' laboratory is supported by a European Research Council (ERC) grant (Y.P.) and by the Danish National Advanced Technology Foundation, the Danish Council for Strategic Research, the Danish Council for Independent Research, the Novo Nordisk Foundation, the Lundbeck Foundation, and the Danish Cancer Society (A.H.L.). Y.P. is an incumbent of the Ben-May Professorial Chair. S.M.K. was supported by a postdoctoral fellowship from the Netherlands Organisation for scientific research (NWO). The Centre for Epigenetics is supported by the Danish National Research Foundation (DNRF82). We thank Simon Kasif and Erez Dekel for stimulating discussions.
PY - 2014
Y1 - 2014
N2 - A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.
AB - A dichotomous choice for metazoan cells is between proliferation and differentiation. Measuring tRNA pools in various cell types, we found two distinct subsets, one that is induced in proliferating cells, and repressed otherwise, and another with the opposite signature. Correspondingly, we found that genes serving cell-autonomous functions and genes involved in multicellularity obey distinct codon usage. Proliferation-induced and differentiation-induced tRNAs often carry anticodons that correspond to the codons enriched among the cell-autonomous and the multicellularity genes, respectively. Because mRNAs of cell-autonomous genes are induced in proliferation and cancer in particular, the concomitant induction of their codon-enriched tRNAs suggests coordination between transcription and translation. Histone modifications indeed change similarly in the vicinity of cell-autonomous genes and their corresponding tRNAs, and in multicellularity genes and their tRNAs, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Hence, we describe the existence of two distinct translation programs that operate during proliferation and differentiation.
UR - https://www.scopus.com/pages/publications/84908078106
U2 - 10.1016/j.cell.2014.08.011
DO - 10.1016/j.cell.2014.08.011
M3 - Article
C2 - 25215487
SN - 0092-8674
VL - 158
SP - 1281
EP - 1292
JO - Cell
JF - Cell
IS - 6
ER -
SDG 3 Good Health and Well-being