A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila

Sebastian Kittelmann; Ella Preger-Ben Noon; Alistair P. McGregor; Nicolás Frankel

doi:10.1016/j.gde.2021.01.003

A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila

Sebastian Kittelmann, Ella Preger-Ben Noon, Alistair P. McGregor, Nicolás Frankel

Medicine

Technion - Israel Institute of Technology

Research output: Contribution to journal › Review article › peer-review

Abstract

The cuticle of insects is decorated with non-sensory hairs called trichomes. A few Drosophila species independently lost most of the dorso-lateral trichomes on first instar larvae. Genetic experiments revealed that this naked cuticle phenotype was caused by the evolution of enhancer function at the ovo/shavenbaby (ovo/svb) locus. Here we explore how this discovery catalyzed major new insights into morphological evolution in different developmental contexts, enhancer pleiotropy in gene regulation and the functionality and evolution of the Svb gene regulatory network (GRN). Taken together this highlights the importance of understanding the architecture and evolution of gene regulatory networks in detail and the great potential for further study of the Svb GRN.

Original language	English
Pages (from-to)	21-27
Number of pages	7
Journal	Current Opinion in Genetics and Development
Volume	69
DOIs	https://doi.org/10.1016/j.gde.2021.01.003
State	Published - Aug 2021

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

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10.1016/j.gde.2021.01.003

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title = "A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila",

abstract = "The cuticle of insects is decorated with non-sensory hairs called trichomes. A few Drosophila species independently lost most of the dorso-lateral trichomes on first instar larvae. Genetic experiments revealed that this naked cuticle phenotype was caused by the evolution of enhancer function at the ovo/shavenbaby (ovo/svb) locus. Here we explore how this discovery catalyzed major new insights into morphological evolution in different developmental contexts, enhancer pleiotropy in gene regulation and the functionality and evolution of the Svb gene regulatory network (GRN). Taken together this highlights the importance of understanding the architecture and evolution of gene regulatory networks in detail and the great potential for further study of the Svb GRN.",

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T1 - A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila

AU - Kittelmann, Sebastian

AU - Preger-Ben Noon, Ella

AU - McGregor, Alistair P.

AU - Frankel, Nicolás

PY - 2021/8

Y1 - 2021/8

N2 - The cuticle of insects is decorated with non-sensory hairs called trichomes. A few Drosophila species independently lost most of the dorso-lateral trichomes on first instar larvae. Genetic experiments revealed that this naked cuticle phenotype was caused by the evolution of enhancer function at the ovo/shavenbaby (ovo/svb) locus. Here we explore how this discovery catalyzed major new insights into morphological evolution in different developmental contexts, enhancer pleiotropy in gene regulation and the functionality and evolution of the Svb gene regulatory network (GRN). Taken together this highlights the importance of understanding the architecture and evolution of gene regulatory networks in detail and the great potential for further study of the Svb GRN.

AB - The cuticle of insects is decorated with non-sensory hairs called trichomes. A few Drosophila species independently lost most of the dorso-lateral trichomes on first instar larvae. Genetic experiments revealed that this naked cuticle phenotype was caused by the evolution of enhancer function at the ovo/shavenbaby (ovo/svb) locus. Here we explore how this discovery catalyzed major new insights into morphological evolution in different developmental contexts, enhancer pleiotropy in gene regulation and the functionality and evolution of the Svb gene regulatory network (GRN). Taken together this highlights the importance of understanding the architecture and evolution of gene regulatory networks in detail and the great potential for further study of the Svb GRN.

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DO - 10.1016/j.gde.2021.01.003

M3 - مقالة مرجعية

SN - 0959-437X

VL - 69

SP - 21

EP - 27

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

ER -

A complex gene regulatory architecture underlies the development and evolution of cuticle morphology in Drosophila

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