A Close Encounter of the Third Kind. Monocyte-Derived Cells: Monocyte-Derived Cells

Alexander Mildner, Simon Yona, Steffen Jung

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Recent insights into discrete myeloid developmental pathways have provided critical information about the organization of the murine mononuclear phagocyte compartment. Short-lived dendritic cells (DCs) have been shown to continuously arise from dedicated bone marrow-derived precursors. In contrast, it is now appreciated that most tissue macrophage populations are established before birth and subsequently maintain themselves throughout adulthood by longevity and limited self-renewal. Both of these classical tissue-resident mononuclear phagocyte compartments can be complemented on demand by monocyte infiltrates giving rise to macrophage or DC-like cells, depending on the tissue context they encounter upon extravasation. Monocytes hence have emerged as a versatile emergency squad that can be rapidly recruited to sites of injury to provide a transient supplement with proinflammatory or resolving activities for local mononuclear phagocytes.

Original languageEnglish
Title of host publicationAdvances in Immunology
PublisherAcademic Press Inc.
Pages69-103
Number of pages35
DOIs
StatePublished - 2013

Publication series

NameAdvances in Immunology
Volume120

Keywords

  • Dendritic cells
  • Macrophages
  • Monocytes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

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