A cistrome roadmap for understanding pancreatic islet biology

Dana Avrahami; Klaus H. Kaestner

doi:10.1038/ng.2880

A cistrome roadmap for understanding pancreatic islet biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Although dozens of common variants have been associated with increased risk of type 2 diabetes (T2D), the mechanisms by which these variants increase disease susceptibility are largely unknown. A new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and suggests that altered enhancer function might be a common contributor to the genetic risk of T2D.

Original language	English
Pages (from-to)	95-96
Number of pages	2
Journal	Nature Genetics
Volume	46
Issue number	2
DOIs	https://doi.org/10.1038/ng.2880
State	Published - Feb 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Genetics

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10.1038/ng.2880

Cite this

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AB - Although dozens of common variants have been associated with increased risk of type 2 diabetes (T2D), the mechanisms by which these variants increase disease susceptibility are largely unknown. A new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and suggests that altered enhancer function might be a common contributor to the genetic risk of T2D.

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A cistrome roadmap for understanding pancreatic islet biology

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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