A cistrome roadmap for understanding pancreatic islet biology

Dana Avrahami; Klaus H. Kaestner

doi:10.1038/ng.2880

A cistrome roadmap for understanding pancreatic islet biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Although dozens of common variants have been associated with increased risk of type 2 diabetes (T2D), the mechanisms by which these variants increase disease susceptibility are largely unknown. A new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and suggests that altered enhancer function might be a common contributor to the genetic risk of T2D.

Original language	English
Pages (from-to)	95-96
Number of pages	2
Journal	Nature Genetics
Volume	46
Issue number	2
DOIs	https://doi.org/10.1038/ng.2880
State	Published - Feb 2014
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.2880

Cite this

@article{bdf9205ffb2e44adb97b4f594fae7e2d,

title = "A cistrome roadmap for understanding pancreatic islet biology",

abstract = "Although dozens of common variants have been associated with increased risk of type 2 diabetes (T2D), the mechanisms by which these variants increase disease susceptibility are largely unknown. A new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and suggests that altered enhancer function might be a common contributor to the genetic risk of T2D.",

author = "Dana Avrahami and Kaestner, {Klaus H.}",

year = "2014",

month = feb,

doi = "10.1038/ng.2880",

language = "الإنجليزيّة",

volume = "46",

pages = "95--96",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "2",

}

TY - JOUR

T1 - A cistrome roadmap for understanding pancreatic islet biology

AU - Avrahami, Dana

AU - Kaestner, Klaus H.

PY - 2014/2

Y1 - 2014/2

N2 - Although dozens of common variants have been associated with increased risk of type 2 diabetes (T2D), the mechanisms by which these variants increase disease susceptibility are largely unknown. A new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and suggests that altered enhancer function might be a common contributor to the genetic risk of T2D.

AB - Although dozens of common variants have been associated with increased risk of type 2 diabetes (T2D), the mechanisms by which these variants increase disease susceptibility are largely unknown. A new study mapping the human pancreatic islet cistrome provides a roadmap for exploring the effects of these variants and suggests that altered enhancer function might be a common contributor to the genetic risk of T2D.

UR - http://www.scopus.com/inward/record.url?scp=84895819073&partnerID=8YFLogxK

U2 - 10.1038/ng.2880

DO - 10.1038/ng.2880

M3 - مقالة مرجعية

C2 - 24473321

SN - 1061-4036

VL - 46

SP - 95

EP - 96

JO - Nature Genetics

JF - Nature Genetics

IS - 2

ER -

A cistrome roadmap for understanding pancreatic islet biology

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Cite this