A child exposed to primidone not prescribed for her

Reo Tanoshima; Geert Jong; Anthony Merlocco; Jeremy N. Simpson; Jeremy Friedman; David Colantonio; Gideon Koren

doi:https://doi.org/10.1097/FTD.0b013e3182843206

A child exposed to primidone not prescribed for her

Reo Tanoshima, Geert Jong, Anthony Merlocco, Jeremy N. Simpson, Jeremy Friedman, David Colantonio, Gideon Koren

Research output: Contribution to journal › Article › peer-review

Abstract

A 7.5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness. She had been known to have high PHB levels of unknown cause, without symptoms. Her PHB levels were very high, as expected, but primidone levels were also detected although she and her parents denied history of primidone administration. We wished to rule out intentional unprescribed use of primidone. Our retrospective review showed 3 other children with high PHB concentrations where primidone was also detected when PHB levels were over 130 μmol/L. Complementary studies confirmed that high-dose PHB can convert to its prodrug primidone, which has not been reported previously.

Original language	English
Pages (from-to)	145-149
Number of pages	5
Journal	Therapeutic Drug Monitoring
Volume	35
Issue number	2
DOIs	https://doi.org/10.1097/FTD.0b013e3182843206
State	Published - Apr 2013
Externally published	Yes

Keywords

clinical pharmacology
phenobarbital
primidone
therapeutic drug monitoring

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)

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https://doi.org/10.1097/FTD.0b013e3182843206

Cite this

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title = "A child exposed to primidone not prescribed for her",

abstract = "A 7.5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness. She had been known to have high PHB levels of unknown cause, without symptoms. Her PHB levels were very high, as expected, but primidone levels were also detected although she and her parents denied history of primidone administration. We wished to rule out intentional unprescribed use of primidone. Our retrospective review showed 3 other children with high PHB concentrations where primidone was also detected when PHB levels were over 130 μmol/L. Complementary studies confirmed that high-dose PHB can convert to its prodrug primidone, which has not been reported previously.",

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AU - Tanoshima, Reo

AU - Jong, Geert

AU - Merlocco, Anthony

AU - Simpson, Jeremy N.

AU - Friedman, Jeremy

AU - Colantonio, David

AU - Koren, Gideon

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AB - A 7.5-year-old girl who was treated with phenobarbital (PHB) for epilepsy was admitted with decreased levels of consciousness. She had been known to have high PHB levels of unknown cause, without symptoms. Her PHB levels were very high, as expected, but primidone levels were also detected although she and her parents denied history of primidone administration. We wished to rule out intentional unprescribed use of primidone. Our retrospective review showed 3 other children with high PHB concentrations where primidone was also detected when PHB levels were over 130 μmol/L. Complementary studies confirmed that high-dose PHB can convert to its prodrug primidone, which has not been reported previously.

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A child exposed to primidone not prescribed for her

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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