A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Nissim Benvenisty; Jonathan S. Draper; Paul J. Gokhale; Lyn Healy; Zoe Hewitt; Deborah Hursh; Adam Hodgson; Tenneille E. Ludwig; Nancy Mah; Sarah E. McClelland; Milena Mennecozzi; Florian T. Merkle; Joanne C. Mountford; Martin Pera; Alessandro Prigione; Tristan A. Rodriguez; Andrea Rossi; Foad J. Rouhani; Kourosh Saeb-Parsy; Lucia Selfa Aspiroz; Nika Shakiba; Claudia Spits; Peter D. Tonge; Ivana Barbaric

doi:10.1016/j.stem.2025.03.003

A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Nissim Benvenisty, Jonathan S. Draper, Paul J. Gokhale, Lyn Healy, Zoe Hewitt, Deborah Hursh, Adam Hodgson, Tenneille E. Ludwig, Nancy Mah, Sarah E. McClelland, Milena Mennecozzi, Florian T. Merkle, Joanne C. Mountford, Martin Pera, Alessandro Prigione, Tristan A. Rodriguez, Andrea Rossi, Foad J. Rouhani, Kourosh Saeb-Parsy, Lucia Selfa AspirozNika Shakiba, Claudia Spits, Peter D. Tonge, Ivana Barbaric

Department of Genetics

The Hebrew University of Jerusalem

Research output: Contribution to journal › Comment/debate

Abstract

Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

Original language	English
Pages (from-to)	508-512
Number of pages	5
Journal	Cell Stem Cell
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2025.03.003
State	Published - 3 Apr 2025

All Science Journal Classification (ASJC) codes

Molecular Medicine
Genetics
Cell Biology

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Benvenisty, N., Draper, J. S., Gokhale, P. J., Healy, L., Hewitt, Z., Hursh, D., Hodgson, A., Ludwig, T. E., Mah, N., McClelland, S. E., Mennecozzi, M., Merkle, F. T., Mountford, J. C., Pera, M., Prigione, A., Rodriguez, T. A., Rossi, A., Rouhani, F. J., Saeb-Parsy, K., ... Barbaric, I. (2025). A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy. Cell Stem Cell, 32(4), 508-512. https://doi.org/10.1016/j.stem.2025.03.003

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title = "A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy",

abstract = "Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.",

author = "Nissim Benvenisty and Draper, {Jonathan S.} and Gokhale, {Paul J.} and Lyn Healy and Zoe Hewitt and Deborah Hursh and Adam Hodgson and Ludwig, {Tenneille E.} and Nancy Mah and McClelland, {Sarah E.} and Milena Mennecozzi and Merkle, {Florian T.} and Mountford, {Joanne C.} and Martin Pera and Alessandro Prigione and Rodriguez, {Tristan A.} and Andrea Rossi and Rouhani, {Foad J.} and Kourosh Saeb-Parsy and {Selfa Aspiroz}, Lucia and Nika Shakiba and Claudia Spits and Tonge, {Peter D.} and Ivana Barbaric",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

month = apr,

day = "3",

doi = "10.1016/j.stem.2025.03.003",

language = "الإنجليزيّة",

volume = "32",

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Benvenisty, N, Draper, JS, Gokhale, PJ, Healy, L, Hewitt, Z, Hursh, D, Hodgson, A, Ludwig, TE, Mah, N, McClelland, SE, Mennecozzi, M, Merkle, FT, Mountford, JC, Pera, M, Prigione, A, Rodriguez, TA, Rossi, A, Rouhani, FJ, Saeb-Parsy, K, Selfa Aspiroz, L, Shakiba, N, Spits, C, Tonge, PD & Barbaric, I 2025, 'A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy', Cell Stem Cell, vol. 32, no. 4, pp. 508-512. https://doi.org/10.1016/j.stem.2025.03.003

TY - JOUR

T1 - A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

AU - Benvenisty, Nissim

AU - Draper, Jonathan S.

AU - Gokhale, Paul J.

AU - Healy, Lyn

AU - Hewitt, Zoe

AU - Hursh, Deborah

AU - Hodgson, Adam

AU - Ludwig, Tenneille E.

AU - Mah, Nancy

AU - McClelland, Sarah E.

AU - Mennecozzi, Milena

AU - Merkle, Florian T.

AU - Mountford, Joanne C.

AU - Pera, Martin

AU - Prigione, Alessandro

AU - Rodriguez, Tristan A.

AU - Rossi, Andrea

AU - Rouhani, Foad J.

AU - Saeb-Parsy, Kourosh

AU - Selfa Aspiroz, Lucia

AU - Shakiba, Nika

AU - Spits, Claudia

AU - Tonge, Peter D.

AU - Barbaric, Ivana

PY - 2025/4/3

Y1 - 2025/4/3

N2 - Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

AB - Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

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U2 - 10.1016/j.stem.2025.03.003

DO - 10.1016/j.stem.2025.03.003

M3 - تعليقَ / نقاش

SN - 1934-5909

VL - 32

SP - 508

EP - 512

JO - Cell Stem Cell

JF - Cell Stem Cell

IS - 4

ER -

A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Abstract

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