A bio. tools collection of online resources for GPCR research

Tõnis Laasfeld; Friederike Wunsch; Avgi E. Apostolakou; Adrián García-Recio; Gáspár Pándy-Szekeres; Slawomir Filipek; Masha Y. Niv; Jana Selent; David E. Gloriam; Marcel Bermudez

doi:10.1111/bph.17461

A bio. tools collection of online resources for GPCR research

Tõnis Laasfeld, Friederike Wunsch, Avgi E. Apostolakou, Adrián García-Recio, Gáspár Pándy-Szekeres, Slawomir Filipek, Masha Y. Niv, Jana Selent, David E. Gloriam, Marcel Bermudez

Institute of Biochemistry, Food Science and Nutrition

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.

Original language	English
Journal	British Journal of Pharmacology
DOIs	https://doi.org/10.1111/bph.17461
State	Accepted/In press - 2025

Keywords

G protein-coupled receptors
bioinformatics
databases
drug design
web tools

All Science Journal Classification (ASJC) codes

Pharmacology

Access to Document

10.1111/bph.17461

Cite this

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title = "A bio. tools collection of online resources for GPCR research",

abstract = "G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.",

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author = "T{\~o}nis Laasfeld and Friederike Wunsch and Apostolakou, \{Avgi E.\} and Adri{\'a}n Garc{\'i}a-Recio and G{\'a}sp{\'a}r P{\'a}ndy-Szekeres and Slawomir Filipek and Niv, \{Masha Y.\} and Jana Selent and Gloriam, \{David E.\} and Marcel Bermudez",

note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). British Journal of Pharmacology published by John Wiley \& Sons Ltd on behalf of British Pharmacological Society.",

year = "2025",

doi = "10.1111/bph.17461",

language = "الإنجليزيّة",

journal = "British Journal of Pharmacology",

issn = "0007-1188",

publisher = "John Wiley and Sons Inc.",

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T1 - A bio. tools collection of online resources for GPCR research

AU - Laasfeld, Tõnis

AU - Wunsch, Friederike

AU - Apostolakou, Avgi E.

AU - García-Recio, Adrián

AU - Pándy-Szekeres, Gáspár

AU - Filipek, Slawomir

AU - Niv, Masha Y.

AU - Selent, Jana

AU - Gloriam, David E.

AU - Bermudez, Marcel

PY - 2025

Y1 - 2025

N2 - G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.

AB - G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.

KW - G protein-coupled receptors

KW - bioinformatics

KW - databases

KW - drug design

KW - web tools

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U2 - 10.1111/bph.17461

DO - 10.1111/bph.17461

M3 - مقالة مرجعية

C2 - 39993325

SN - 0007-1188

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

ER -

A bio. tools collection of online resources for GPCR research

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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