A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

Jung Seok Kim; Masha Kolesnikov; Shany Peled-Hajaj; Isabelle Scheyltjens; Yuan Xia; Sebastien Trzebanski; Zhana Haimon; Anat Shemer; Alisa Lubart; Hannah Van Hove; Louise Chappell-Maor; Sigalit Boura-Halfon; Kiavash Movahedi; Pablo Blinder; Steffen Jung

doi:10.1016/j.immuni.2020.11.007

A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

Jung Seok Kim, Masha Kolesnikov, Shany Peled-Hajaj, Isabelle Scheyltjens, Yuan Xia, Sebastien Trzebanski, Zhana Haimon, Anat Shemer, Alisa Lubart, Hannah Van Hove, Louise Chappell-Maor, Sigalit Boura-Halfon, Kiavash Movahedi, Pablo Blinder, Steffen Jung

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

The brain harbors both parenchymal microglia and perivascular macrophages, individual functions of which remain incompletely understood. Kim et al. establish a binary transgenic split Cre system that allows differential targeting and translatome analysis of these cells in the mouse.

Original language	English
Pages (from-to)	176-190.e7
Journal	Immunity
Volume	54
Issue number	1
DOIs	https://doi.org/10.1016/j.immuni.2020.11.007
State	Published - 12 Jan 2021

Keywords

Lyve1 BAM
RiboTag
binary transgenic
brain macrophages
intersectional genetics
meninges
microglia
perivascular macrophages
pia mater
split cre

All Science Journal Classification (ASJC) codes

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2020.11.007

Cite this

Kim, J. S., Kolesnikov, M., Peled-Hajaj, S., Scheyltjens, I., Xia, Y., Trzebanski, S., Haimon, Z., Shemer, A., Lubart, A., Van Hove, H., Chappell-Maor, L., Boura-Halfon, S., Movahedi, K., Blinder, P., & Jung, S. (2021). A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages. Immunity, 54(1), 176-190.e7. https://doi.org/10.1016/j.immuni.2020.11.007

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title = "A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages",

abstract = "The brain harbors both parenchymal microglia and perivascular macrophages, individual functions of which remain incompletely understood. Kim et al. establish a binary transgenic split Cre system that allows differential targeting and translatome analysis of these cells in the mouse.",

keywords = "Lyve1 BAM, RiboTag, binary transgenic, brain macrophages, intersectional genetics, meninges, microglia, perivascular macrophages, pia mater, split cre",

author = "Kim, {Jung Seok} and Masha Kolesnikov and Shany Peled-Hajaj and Isabelle Scheyltjens and Yuan Xia and Sebastien Trzebanski and Zhana Haimon and Anat Shemer and Alisa Lubart and {Van Hove}, Hannah and Louise Chappell-Maor and Sigalit Boura-Halfon and Kiavash Movahedi and Pablo Blinder and Steffen Jung",

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year = "2021",

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doi = "10.1016/j.immuni.2020.11.007",

language = "الإنجليزيّة",

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Kim, JS, Kolesnikov, M, Peled-Hajaj, S, Scheyltjens, I, Xia, Y, Trzebanski, S, Haimon, Z, Shemer, A, Lubart, A, Van Hove, H, Chappell-Maor, L, Boura-Halfon, S, Movahedi, K, Blinder, P & Jung, S 2021, 'A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages', Immunity, vol. 54, no. 1, pp. 176-190.e7. https://doi.org/10.1016/j.immuni.2020.11.007

TY - JOUR

T1 - A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

AU - Kim, Jung Seok

AU - Kolesnikov, Masha

AU - Peled-Hajaj, Shany

AU - Scheyltjens, Isabelle

AU - Xia, Yuan

AU - Trzebanski, Sebastien

AU - Haimon, Zhana

AU - Shemer, Anat

AU - Lubart, Alisa

AU - Van Hove, Hannah

AU - Chappell-Maor, Louise

AU - Boura-Halfon, Sigalit

AU - Movahedi, Kiavash

AU - Blinder, Pablo

AU - Jung, Steffen

PY - 2021/1/12

Y1 - 2021/1/12

N2 - The brain harbors both parenchymal microglia and perivascular macrophages, individual functions of which remain incompletely understood. Kim et al. establish a binary transgenic split Cre system that allows differential targeting and translatome analysis of these cells in the mouse.

AB - The brain harbors both parenchymal microglia and perivascular macrophages, individual functions of which remain incompletely understood. Kim et al. establish a binary transgenic split Cre system that allows differential targeting and translatome analysis of these cells in the mouse.

KW - Lyve1 BAM

KW - RiboTag

KW - binary transgenic

KW - brain macrophages

KW - intersectional genetics

KW - meninges

KW - microglia

KW - perivascular macrophages

KW - pia mater

KW - split cre

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U2 - 10.1016/j.immuni.2020.11.007

DO - 10.1016/j.immuni.2020.11.007

M3 - مقالة

C2 - 33333014

SN - 1074-7613

VL - 54

SP - 176-190.e7

JO - Immunity

JF - Immunity

IS - 1

ER -

A Binary Cre Transgenic Approach Dissects Microglia and CNS Border-Associated Macrophages

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

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