TY - JOUR
T1 - 9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models
AU - Twitto-Greenberg, Rachel
AU - Liraz-Zaltsman, Sigal
AU - Michaelson, Daniel M.
AU - Liraz, Ori
AU - Lubitz, Irit
AU - Atrakchi-Baranes, Dana
AU - Shemesh, Chen
AU - Ashery, Uri
AU - Cooper, Itzik
AU - Harari, Ayelet
AU - Harats, Dror
AU - Schnaider-Beeri, Michal
AU - Shaish, Aviv
N1 - Publisher Copyright: © 2023 Elsevier Inc.
PY - 2024/1
Y1 - 2024/1
N2 - A significant progressive decline in beta-carotene (βC) levels in the brain is associated with cognitive impairment and a higher prevalence of Alzheimer's disease (AD). In this study, we investigated whether the administration of 9-cis beta-carotene (9CBC)-rich powder of the alga Dunaliella bardawil, the best-known source of βC in nature, inhibits the development of AD-like neuropathology and cognitive deficits. We demonstrated that in 3 AD mouse models, Tg2576, 5xFAD, and apoE4, 9CBC treatment improved long- and short-term memory, decreased neuroinflammation, and reduced the prevalence of β-amyloid plaques and tau hyperphosphorylation. These findings suggest that 9CBC has the potential to be an effective preventive and symptomatic AD therapy.
AB - A significant progressive decline in beta-carotene (βC) levels in the brain is associated with cognitive impairment and a higher prevalence of Alzheimer's disease (AD). In this study, we investigated whether the administration of 9-cis beta-carotene (9CBC)-rich powder of the alga Dunaliella bardawil, the best-known source of βC in nature, inhibits the development of AD-like neuropathology and cognitive deficits. We demonstrated that in 3 AD mouse models, Tg2576, 5xFAD, and apoE4, 9CBC treatment improved long- and short-term memory, decreased neuroinflammation, and reduced the prevalence of β-amyloid plaques and tau hyperphosphorylation. These findings suggest that 9CBC has the potential to be an effective preventive and symptomatic AD therapy.
KW - 9-cis beta-carotene
KW - Alzheimer's disease
KW - Beta-carotene
KW - Cognition
KW - Dunaliella
KW - Inflammation
UR - http://www.scopus.com/inward/record.url?scp=85175207724&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.neurobiolaging.2023.09.005
DO - https://doi.org/10.1016/j.neurobiolaging.2023.09.005
M3 - مقالة
C2 - 38381472
SN - 0197-4580
VL - 133
SP - 16
EP - 27
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -