BRCA1 promotes 5′-3′ end resection and subsequently loads RAD51 onto 3′ single-stranded DNA to initiate homologous recombination. Callen et al. demonstrate that 53BP1 antagonizes both key steps in homologous recombination—end resection and RAD51 loading—that are coordinated by BRCA1.
- homologous recombination
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology