50 Shades of CLEM: How to choose the right approach for you

Nadav Scher, Ori Avinoam

Research output: Chapter in Book/Report/Conference proceedingChapter


Correlative light and electron microscopy (CLEM) combines the strengths of light microscopy (LM) and electron microscopy (EM) to pin-point and visualize cellular or macromolecular structures. However, there are many different imaging modalities that can be combined in a CLEM workflow, creating a vast number of combinations that can overwhelm new-comers to the field. Here, we offer a conceptual framework to help guide the decision-making process for choosing the CLEM workflow that can best address your research question, based on the answer to five questions.
Original languageEnglish
Title of host publicationCorrelative Light and Electron Microscopy IV
StatePublished - 2021

Publication series

NameMethods in Cell Biology
ISSN (Print)0091-679X


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