γδ T cells regulate the intestinal response to nutrient sensing

Zuri A Sullivan; William Khoury-Hanold; Jaechul Lim; Chris Smillie; Moshe Biton; Bernardo S Reis; Rachel K Zwick; Scott D Pope; Kavita Israni-Winger; Roham Parsa; Naomi H Philip; Saleh Rashed; Noah Palm; Andrew Wang; Daniel Mucida; Aviv Regev; Ruslan Medzhitov

doi:https://doi.org/10.1126/science.aba8310

γδ T cells regulate the intestinal response to nutrient sensing

Zuri A Sullivan, William Khoury-Hanold, Jaechul Lim, Chris Smillie, Moshe Biton, Bernardo S Reis, Rachel K Zwick, Scott D Pope, Kavita Israni-Winger, Roham Parsa, Naomi H Philip, Saleh Rashed, Noah Palm, Andrew Wang, Daniel Mucida, Aviv Regev, Ruslan Medzhitov

Research output: Contribution to journal › Article › peer-review

Abstract

The intestine is a site of direct encounter with the external environment and must consequently balance barrier defense with nutrient uptake. To investigate how nutrient uptake is regulated in the small intestine, we tested the effect of diets with different macronutrient compositions on epithelial gene expression. We found that enzymes and transporters required for carbohydrate digestion and absorption were regulated by carbohydrate availability. The "on-demand" induction of this machinery required γδ T cells, which regulated this program through the suppression of interleukin-22 production by type 3 innate lymphoid cells. Nutrient availability altered the tissue localization and transcriptome of γδ T cells. Additionally, transcriptional responses to diet involved cellular remodeling of the epithelial compartment. Thus, this work identifies a role for γδ T cells in nutrient sensing.

Original language	English
Article number	eaba8310
Number of pages	13
Journal	Science (American Association for the Advancement of Science)
Volume	371
Issue number	6535
DOIs	https://doi.org/10.1126/science.aba8310
State	Published - 19 Mar 2021
Externally published	Yes

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Sullivan, Z. A., Khoury-Hanold, W., Lim, J., Smillie, C., Biton, M., Reis, B. S., Zwick, R. K., Pope, S. D., Israni-Winger, K., Parsa, R., Philip, N. H., Rashed, S., Palm, N., Wang, A., Mucida, D., Regev, A., & Medzhitov, R. (2021). γδ T cells regulate the intestinal response to nutrient sensing. Science (American Association for the Advancement of Science), 371(6535), Article eaba8310. https://doi.org/10.1126/science.aba8310

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title = "γδ T cells regulate the intestinal response to nutrient sensing",

abstract = "The intestine is a site of direct encounter with the external environment and must consequently balance barrier defense with nutrient uptake. To investigate how nutrient uptake is regulated in the small intestine, we tested the effect of diets with different macronutrient compositions on epithelial gene expression. We found that enzymes and transporters required for carbohydrate digestion and absorption were regulated by carbohydrate availability. The {"}on-demand{"} induction of this machinery required γδ T cells, which regulated this program through the suppression of interleukin-22 production by type 3 innate lymphoid cells. Nutrient availability altered the tissue localization and transcriptome of γδ T cells. Additionally, transcriptional responses to diet involved cellular remodeling of the epithelial compartment. Thus, this work identifies a role for γδ T cells in nutrient sensing.",

author = "Sullivan, {Zuri A} and William Khoury-Hanold and Jaechul Lim and Chris Smillie and Moshe Biton and Reis, {Bernardo S} and Zwick, {Rachel K} and Pope, {Scott D} and Kavita Israni-Winger and Roham Parsa and Philip, {Naomi H} and Saleh Rashed and Noah Palm and Andrew Wang and Daniel Mucida and Aviv Regev and Ruslan Medzhitov",

year = "2021",

month = mar,

day = "19",

doi = "https://doi.org/10.1126/science.aba8310",

language = "الإنجليزيّة",

volume = "371",

journal = "Science (American Association for the Advancement of Science)",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

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Sullivan, ZA, Khoury-Hanold, W, Lim, J, Smillie, C, Biton, M, Reis, BS, Zwick, RK, Pope, SD, Israni-Winger, K, Parsa, R, Philip, NH, Rashed, S, Palm, N, Wang, A, Mucida, D, Regev, A & Medzhitov, R 2021, 'γδ T cells regulate the intestinal response to nutrient sensing', Science (American Association for the Advancement of Science), vol. 371, no. 6535, eaba8310. https://doi.org/10.1126/science.aba8310

TY - JOUR

T1 - γδ T cells regulate the intestinal response to nutrient sensing

AU - Sullivan, Zuri A

AU - Khoury-Hanold, William

AU - Lim, Jaechul

AU - Smillie, Chris

AU - Biton, Moshe

AU - Reis, Bernardo S

AU - Zwick, Rachel K

AU - Pope, Scott D

AU - Israni-Winger, Kavita

AU - Parsa, Roham

AU - Philip, Naomi H

AU - Rashed, Saleh

AU - Palm, Noah

AU - Wang, Andrew

AU - Mucida, Daniel

AU - Regev, Aviv

AU - Medzhitov, Ruslan

PY - 2021/3/19

Y1 - 2021/3/19

N2 - The intestine is a site of direct encounter with the external environment and must consequently balance barrier defense with nutrient uptake. To investigate how nutrient uptake is regulated in the small intestine, we tested the effect of diets with different macronutrient compositions on epithelial gene expression. We found that enzymes and transporters required for carbohydrate digestion and absorption were regulated by carbohydrate availability. The "on-demand" induction of this machinery required γδ T cells, which regulated this program through the suppression of interleukin-22 production by type 3 innate lymphoid cells. Nutrient availability altered the tissue localization and transcriptome of γδ T cells. Additionally, transcriptional responses to diet involved cellular remodeling of the epithelial compartment. Thus, this work identifies a role for γδ T cells in nutrient sensing.

AB - The intestine is a site of direct encounter with the external environment and must consequently balance barrier defense with nutrient uptake. To investigate how nutrient uptake is regulated in the small intestine, we tested the effect of diets with different macronutrient compositions on epithelial gene expression. We found that enzymes and transporters required for carbohydrate digestion and absorption were regulated by carbohydrate availability. The "on-demand" induction of this machinery required γδ T cells, which regulated this program through the suppression of interleukin-22 production by type 3 innate lymphoid cells. Nutrient availability altered the tissue localization and transcriptome of γδ T cells. Additionally, transcriptional responses to diet involved cellular remodeling of the epithelial compartment. Thus, this work identifies a role for γδ T cells in nutrient sensing.

U2 - https://doi.org/10.1126/science.aba8310

DO - https://doi.org/10.1126/science.aba8310

M3 - مقالة

C2 - 33737460

SN - 0036-8075

VL - 371

JO - Science (American Association for the Advancement of Science)

JF - Science (American Association for the Advancement of Science)

IS - 6535

M1 - eaba8310

ER -

γδ T cells regulate the intestinal response to nutrient sensing

Abstract

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