α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

Ayala Lampel; Efrat Elis; Tom Guterman; Sharon Shapira; Pini Marco; Eran Bacharach; Ehud Gazit

doi:https://doi.org/10.1039/c5cc01421b

α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

Ayala Lampel, Efrat Elis, Tom Guterman, Sharon Shapira, Pini Marco, Eran Bacharach, Ehud Gazit

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.

Original language	English
Pages (from-to)	12349-12352
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	62
DOIs	https://doi.org/10.1039/c5cc01421b
State	Published - 11 Aug 2015

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1039/c5cc01421b

Cite this

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title = "α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments",

abstract = "The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.",

author = "Ayala Lampel and Efrat Elis and Tom Guterman and Sharon Shapira and Pini Marco and Eran Bacharach and Ehud Gazit",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2015.",

year = "2015",

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doi = "https://doi.org/10.1039/c5cc01421b",

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T1 - α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

AU - Lampel, Ayala

AU - Elis, Efrat

AU - Guterman, Tom

AU - Shapira, Sharon

AU - Marco, Pini

AU - Bacharach, Eran

AU - Gazit, Ehud

PY - 2015/8/11

Y1 - 2015/8/11

N2 - The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.

AB - The design of a cell penetrating antiviral peptide, which is derived from the major homology region of HIV-1 capsid protein and includes the non-coded α-aminoisobutyric acid, provides functional evidence for the role of the conserved region in the HIV assembly process and demonstrates the correlation between conformational stability and cellular permeability.

UR - http://www.scopus.com/inward/record.url?scp=84937786296&partnerID=8YFLogxK

U2 - https://doi.org/10.1039/c5cc01421b

DO - https://doi.org/10.1039/c5cc01421b

M3 - مقالة

SN - 1359-7345

VL - 51

SP - 12349

EP - 12352

JO - Chemical Communications

JF - Chemical Communications

IS - 62

ER -

α-Aminoisobutyric acid incorporation induces cell permeability and antiviral activity of HIV-1 major homology region fragments

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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