Research output per year
Research output per year
- 43 results
Search results
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2024
Differentiation shifts from a reversible to an irreversible heterochromatin state at the DM1 locus
Handal, T., Juster, S., Abu Diab, M., Yanovsky-Dagan, S., Zahdeh, F., Aviel, U., Sarel-Gallily, R., Michael, S., Bnaya, E., Sebban, S., Buganim, Y., Drier, Y., Mouly, V., Kubicek, S., van den Broek, W. J. A. A., Wansink, D. G., Epsztejn-Litman, S. & Eiges, R., Dec 2024, In: Nature Communications. 15, 1, 3270.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Nucleosome fibre topology guides transcription factor binding to enhancers
O’Dwyer, M. R., Azagury, M., Furlong, K., Alsheikh, A., Hall-Ponsele, E., Pinto, H., Fyodorov, D. V., Jaber, M., Papachristoforou, E., Benchetrit, H., Ashmore, J., Makedonski, K., Rahamim, M., Hanzevacki, M., Yassen, H., Skoda, S., Levy, A., Pollard, S. M., Skoultchi, A. I., Buganim, Y., & 1 others, 2024, (Accepted/In press) In: Nature. 11485.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Transdifferentiation occurs without resetting development-specific DNA methylation, a key determinant of full-function cell identity
Radwan, A., Eccleston, J., Sabag, O., Marcus, H., Sussman, J., Ouro, A., Rahamim, M., Azagury, M., Azria, B., Stanger, B. Z., Cedar, H. & Buganim, Y., 30 Sep 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 39, e2411352121.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Unlocking trophectoderm mysteries: In vivo and in vitro perspectives on human and mouse trophoblast fate induction
Azagury, M. & Buganim, Y., 22 Apr 2024, In: Developmental Cell. 59, 8, p. 941-960 20 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Review article › peer-review
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2023
Complex haploinsufficiency in pluripotent cells yields somatic cells with DNA methylation abnormalities and pluripotency induction defects
Lasry, R., Maoz, N., Cheng, A. W., Yom Tov, N., Kulenkampff, E., Azagury, M., Yang, H., Ople, C., Markoulaki, S., Faddah, D. A., Makedonski, K., Orzech, D., Sabag, O., Jaenisch, R. & Buganim, Y., 14 Nov 2023, In: Stem Cell Reports. 18, 11, p. 2174-2189 16 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Human trophoblast stem cell-state acquisition from pluripotent stem cells and somatic cells
Naama, M. & Buganim, Y., Aug 2023, In: Current Opinion in Genetics and Development. 81, 102084.The Hebrew University of Jerusalem
Research output: Contribution to journal › Review article › peer-review
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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
Sun, C., Seranova, E., Cohen, M. A., Chipara, M., Roberts, J., Astuti, D., Palhegyi, A. M., Acharjee, A., Sedlackova, L., Kataura, T., Otten, E. G., Panda, P. K., Lara-Reyna, S., Korsgen, M. E., Kauffman, K. J., Huerta-Uribe, A., Zatyka, M., Silva, L. F. S. E., Torresi, J., Zhang, S., & 20 others, 30 May 2023, In: Cell Reports. 42, 5, 112372.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Pluripotency-independent induction of human trophoblast stem cells from fibroblasts
Naama, M., Rahamim, M., Zayat, V., Sebban, S., Radwan, A., Orzech, D., Lasry, R., Ifrah, A., Jaber, M., Sabag, O., Yassen, H., Khatib, A., Epsztejn-Litman, S., Novoselsky-Persky, M., Makedonski, K., Deri, N., Goldman-Wohl, D., Cedar, H., Yagel, S., Eiges, R., & 1 others, 8 Jun 2023, In: Nature Communications. 14, 1, 3359.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Comparative parallel multi-omics analysis during the induction of pluripotent and trophectoderm states
Jaber, M., Radwan, A., Loyfer, N., Abdeen, M., Sebban, S., Khatib, A., Yassen, H., Kolb, T., Zapatka, M., Makedonski, K., Ernst, A., Kaplan, T. & Buganim, Y., 17 Jun 2022, In: Nature Communications. 13, 1, 3475.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Esrrb is a cell-cycle-dependent associated factor balancing pluripotency and XEN differentiation
Herchcovici Levy, S., Feldman Cohen, S., Arnon, L., Lahav, S., Awawdy, M., Alajem, A., Bavli, D., Sun, X., Buganim, Y. & Ram, O., 14 Jun 2022, In: Stem Cell Reports. 17, 6, p. 1334-1350 17 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
In silico Docking Analysis for Blocking JUNO‐IZUMO1 Interaction Identifies Two Small Molecules that Block in vitro Fertilization
Stepanenko, N., Wolk, O., Bianchi, E., Wright, G. J., Schachter-Safrai, N., Makedonski, K., Ouro, A., Ben-Meir, A., Buganim, Y. & Goldblum, A., 5 Apr 2022, In: Frontiers in Cell and Developmental Biology. 10, 824629.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Apoptotic cells represent a dynamic stem cell niche governing proliferation and tissue regeneration
Ankawa, R., Goldberger, N., Yosefzon, Y., Koren, E., Yusupova, M., Rosner, D., Feldman, A., Baror-Sebban, S., Buganim, Y., Simon, D. J., Tessier-Lavigne, M. & Fuchs, Y., 12 Jul 2021, In: Developmental Cell. 56, 13, p. 1900-1916.e5The Hebrew University of Jerusalem, Technion - Israel Institute of Technology
Research output: Contribution to journal › Article › peer-review
Open Access -
A versatile system to introduce clusters of genomic double-strand breaks in large cell populations
Kolb, T., Khalid, U., Simović, M., Ratnaparkhe, M., Wong, J., Jauch, A., Schmezer, P., Rode, A., Sebban, S., Haag, D., Hergt, M., Devens, F., Buganim, Y., Zapatka, M., Lichter, P. & Ernst, A., May 2021, In: Genes Chromosomes and Cancer. 60, 5, p. 303-313 11 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting neurons in the tumor microenvironment with bupivacaine nanoparticles reduces breast cancer progression and metastases
Kaduri, M., Sela, M., Kagan, S., Poley, M., Abumanhal-Masarweh, H., Mora-Raimundo, P., Ouro, A., Dahan, N., Hershkovitz, D., Shklover, J., Shainsky-Roitman, J., Buganim, Y. & Schroeder, A., 1 Oct 2021, In: Science Advances. 7, 41, eabj5435.The Hebrew University of Jerusalem, Technion - Israel Institute of Technology
Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Human Induced Pluripotent Stem Cell Models of Neurodegenerative Disorders for Studying the Biomedical Implications of Autophagy
Seranova, E., Palhegyi, A. M., Verma, S., Dimova, S., Lasry, R., Naama, M., Sun, C., Barrett, T., Rosenstock, T. R., Kumar, D., Cohen, M. A., Buganim, Y. & Sarkar, S., 3 Apr 2020, In: Journal of Molecular Biology. 432, 8, p. 2754-2798 45 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Review article › peer-review
Open Access -
Triangular correlation (TrC) between cancer aggressiveness, cell uptake capability, and cell deformability
Brill-Karniely, Y., Dror, D., Duanis-Assaf, T., Goldstein, Y., Schwob, O., Millo, T., Orehov, N., Stern, T., Jaber, M., Loyfer, N., Vosk-Artzi, M., Benyamini, H., Bielenberg, D., Kaplan, T., Buganim, Y., Reches, M. & Benny, O., 2020, In: Science Advances. 6, 3, eaax2861.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts
Benchetrit, H., Jaber, M., Zayat, V., Sebban, S., Pushett, A., Makedonski, K., Zakheim, Z., Radwan, A., Maoz, N., Lasry, R., Renous, N., Inbar, M., Ram, O., Kaplan, T. & Buganim, Y., 6 Jun 2019, In: Cell Stem Cell. 24, 6, p. 983-994.e7The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Fine-Tuning Mybl2 Is Required for Proper Mesenchymal-to-Epithelial Transition during Somatic Reprogramming
Ward, C., Volpe, G., Cauchy, P., Ptasinska, A., Almaghrabi, R., Blakemore, D., Nafria, M., Kestner, D., Frampton, J., Murphy, G., Buganim, Y., Kaji, K. & García, P., 7 Aug 2018, In: Cell Reports. 24, 6, p. 1496-1511.e8The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Germline DNA replication timing shapes mammalian genome composition
Yehuda, Y., Blumenfeld, B., Mayorek, N., Makedonski, K., Vardi, O., Cohen-Daniel, L., Mansour, Y., Baror-Sebban, S., Masika, H., Farago, M., Berger, M., Carmi, S., Buganim, Y., Koren, A. & Simon, I., 19 Sep 2018, In: Nucleic acids research. 46, 16, p. 8299-8310 12 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2017
Acquisition of the pluripotent and trophectoderm states in the embryo and during somatic nuclear reprogramming
Jaber, M., Sebban, S. & Buganim, Y., Oct 2017, In: Current Opinion in Genetics and Development. 46, p. 37-43 7 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Review article › peer-review
Open Access -
Moving towards totipotency without a single miR-acle
Maoz, N. & Buganim, Y., 1 May 2017, In: Cell Research. 27, 5, p. 600-601 2 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Review article › peer-review
Open Access -
Programming asynchronous replication in stem cells
Masika, H., Farago, M., Hecht, M., Condiotti, R., Makedonski, K., Buganim, Y., Burstyn-Cohen, T., Bergman, Y. & Cedar, H., 2017, In: Nature Structural and Molecular Biology. 24, 12, p. 1132-1138 7 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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2016
Back to basics: Refined nuclear reprogramming techniques yield higher-quality stem cells
Buganim, Y., 17 Jun 2016, In: Science. 352, 6292, p. 1401 1 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Review article › peer-review
Open Access -
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos
Cohen, M. A., Wert, K. J., Goldmann, J., Markoulaki, S., Buganim, Y., Fu, D. & Jaenisch, R., 9 Feb 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 6, p. 1570-1575 6 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Nuclear Reprogramming by Defined Factors: Quantity Versus Quality
Sebban, S. & Buganim, Y., 1 Jan 2016, In: Trends in Cell Biology. 26, 1, p. 65-75 11 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Review article › peer-review
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2015
Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells
Benchetrit, H., Herman, S., Van Wietmarschen, N., Wu, T., Makedonski, K., Maoz, N., Yom Tov, N., Stave, D., Lasry, R., Zayat, V., Xiao, A., Lansdorp, P. M., Sebban, S. & Buganim, Y., 5 Nov 2015, In: Cell Stem Cell. 17, 5, p. 543-556 14 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Tex10: A New Player in the Core Pluripotency Circuitry
Buganim, Y., 4 Jun 2015, In: Cell Stem Cell. 16, 6, p. 572-573 2 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Short survey › peer-review
Open Access -
2014
The developmental potential of iPSCs is greatly influenced by reprogramming factor selection
Buganim, Y., Markoulaki, S., Van Wietmarschen, N., Hoke, H., Wu, T., Ganz, K., Akhtar-Zaidi, B., He, Y., Abraham, B. J., Porubsky, D., Kulenkampff, E., Faddah, D. A., Shi, L., Gao, Q., Sarkar, S., Cohen, M., Goldmann, J., Nery, J. R., Schultz, M. D., Ecker, J. R., & 4 others, 2014, In: Cell Stem Cell. 15, 3, p. 295-309 15 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2013
Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
Sahay, G., Querbes, W., Alabi, C., Eltoukhy, A., Sarkar, S., Zurenko, C., Karagiannis, E., Love, K., Chen, D., Zoncu, R., Buganim, Y., Schroeder, A., Langer, R. & Anderson, D. G., Jul 2013, In: Nature biotechnology. 31, 7, p. 653-658 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Impaired autophagy in the lipid-storage disorder niemann-pick type c1 disease
Sarkar, S., Carroll, B., Buganim, Y., Maetzel, D., Ng, A. H. M., Cassady, J. P., Cohen, M. A., Chakraborty, S., Wang, H., Spooner, E., Ploegh, H., Gsponer, J., Korolchuk, V. I. & Jaenisch, R., 12 Dec 2013, In: Cell Reports. 5, 5, p. 1302-1315 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mechanisms and models of somatic cell reprogramming
Buganim, Y., Faddah, D. A. & Jaenisch, R., Jun 2013, In: Nature Reviews Genetics. 14, 6, p. 427-439 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
P53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity
Molchadsky, A., Ezra, O., Amendola, P. G., Krantz, D., Kogan-Sakin, I., Buganim, Y., Rivlin, N., Goldfinger, N., Folgiero, V., Falcioni, R., Sarig, R. & Rotter, V., May 2013, In: Cell Death and Differentiation. 20, 5, p. 774-783 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse escs
Faddah, D. A., Wang, H., Cheng, A. W., Katz, Y., Buganim, Y. & Jaenisch, R., 3 Jul 2013, In: Cell Stem Cell. 13, 1, p. 23-29 7 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2012
Direct reprogramming of fibroblasts into embryonic sertoli-like cells by defined factors
Buganim, Y., Itskovich, E., Hu, Y. C., Cheng, A. W., Ganz, K., Sarkar, S., Fu, D., Welstead, G. G., Page, D. C. & Jaenisch, R., 7 Sep 2012, In: Cell Stem Cell. 11, 3, p. 373-386 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species
Kalo, E., Kogan-Sakin, I., Solomon, H., Bar-Nathan, E., Shay, M., Shetzer, Y., Dekel, E., Goldfinger, N., Buganim, Y., Stambolsky, P., Goldstein, I., Madar, S. & Rotter, V., 15 Nov 2012, In: Journal of Cell Science. 125, 22, p. 5578-5586 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Retraction notice to 'Drosophila Ten-a is a maternal pair-rule and patterning gene' [Mech. Dev. 124 (2007) 911-924]
Rakovitsky, N., Buganim, Y., Swissa, T., Kinel-Tahan, Y., Brenner, S., Cohen, M. A., Levine, A. & Wides, R., Mar 2012, In: Mechanisms of Development. 129, 1-4, p. 73 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
Buganim, Y., Faddah, D. A., Cheng, A. W., Itskovich, E., Markoulaki, S., Ganz, K., Klemm, S. L., Van Oudenaarden, A. & Jaenisch, R., 14 Sep 2012, In: Cell. 150, 6, p. 1209-1222 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Transdifferentiation by defined factors as a powerful research tool to address basic biological questions
Buganim, Y. & Jaenisch, R., 15 Dec 2012, In: Cell Cycle. 11, 24, p. 4485-4486 2 p.Research output: Contribution to journal › Editorial
Open Access -
Tumor-promoting circuits that regulate a cancer-related chemokine cluster: Dominance of inflammatory mediators over oncogenic alterations
Leibovich-Rivkin, T., Buganim, Y., Solomon, H., Meshel, T., Rotter, V. & Ben-Baruch, A., 20 Jan 2012, In: Cancers. 4, 1, p. 55-76 22 p.Weizmann Institute of Science, Tel Aviv University
Research output: Contribution to journal › Article › peer-review
Open Access -
Various p53 mutant proteins differently regulate the ras circuit to induce a cancer-related gene signature
Solomon, H., Buganim, Y., Kogan-Sakin, I., Pomeraniec, L., Assia, Y., Madar, S., Goldstein, I., Brosh, R., Kalo, E., Beatus, T., Goldfinger, N. & Rotter, V., 1 Jul 2012, In: Journal of Cell Science. 125, 13, p. 3144-3152 9 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2011
Amplification of the 20q chromosomal arm occurs early in tumorigenic transformation and may initiate cancer
Tabach, Y., Sakin, I. K., Buganim, Y., Solomon, H., Goldfinger, N., Hovland, R., Ke, X. S., Oyan, A. M., Kalland, K. H., Rotter, V. & Domany, E., 2011, In: PLoS ONE. 6, 1, e14632.Research output: Contribution to journal › Article › peer-review
Open Access -
Mutant p53 R175H upregulates Twist1 expression and promotes epithelial-mesenchymal transition in immortalized prostate cells
Kogan-Sakin, I., Tabach, Y., Buganim, Y., Molchadsky, A., Solomon, H., Madar, S., Kamer, I., Stambolsky, P., Shelly, A., Goldfinger, N., Valsesia-Wittmann, S., Puisieux, A., Zundelevich, A., Gal-Yam, E. N., Avivi, C., Barshack, I., Brait, M., Sidransky, D., Domany, E. & Rotter, V., Feb 2011, In: Cell Death and Differentiation. 18, 2, p. 271-281 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells
Carey, B. W., Markoulaki, S., Hanna, J. H., Faddah, D. A., Buganim, Y., Kim, J., Ganz, K., Steine, E. J., Cassady, J. P., Creyghton, M. P., Welstead, G. G., Gao, Q. & Jaenisch, R., 2 Dec 2011, In: Cell Stem Cell. 9, 6, p. 588-598 11 p.Research output: Contribution to journal › Article › peer-review
Open Access