Personal profile
Research interests
Field: Bioinformatics
Research (active tab)
1. Deep learning in computational biology
2. Computational modeling of protein-DNA and -RNA binding and gene expression regulation
3. Prediction of DNA and RNA structures
4. Predicting protein variant effects based on high-throughput data
5. Algorithms to design DNA, RNA, and amino-acid sequences
6. Data structures and algorithms to analyze high-throughput sequencing data
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Collaborations and top research areas from the last five years
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Mapping the sclerostin–LRP4 binding interface identifies critical interaction hotspots in loops 1 and 3 of sclerostin
Katchkovsky, S., Meiri, R., Lacham-Hartman, S., Orenstein, Y., Levaot, N. & Papo, N., 1 Feb 2025, In: FEBS Letters. 599, 3, p. 316-329 14 p.Ben-Gurion University of the Negev, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access -
A universal system for boosting gene expression in eukaryotic cell-lines
Vaknin, I., Willinger, O., Mandl, J., Heuberger, H., Ben-Ami, D., Zeng, Y., Goldberg, S., Orenstein, Y. & Amit, R., 1 Dec 2024, In: Nature Communications. 15, 1, p. 2394 17 p., 2394.Ben-Gurion University of the Negev, Technion - Israel Institute of Technology, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access -
DeepCRISTL: deep transfer learning to predict CRISPR/Cas9 on-target editing efficiency in specific cellular contexts
Elkayam, S., Tziony, I. & Orenstein, Y., 1 Aug 2024, In: Bioinformatics. 40, 8, 10 p., btae481.Ben-Gurion University of the Negev, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access -
Deep neural networks for predicting the affinity landscape of protein-protein interactions
Meiri, R., Aharoni Lotati, S. L., Orenstein, Y. & Papo, N., 20 Sep 2024, In: iScience. 27, 9, 20 p., 110772.Ben-Gurion University of the Negev, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access -
FiSSC: Finding smallest sequence covers to sets of degenerate reads with applications to RNA editing
Tziony, I., Mandl, J., Shapira, K., Eisenberg, E., Porat, E. & Orenstein, Y., 16 Dec 2024, ACM-BCB 2024 - 15th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics. 10 p. 13. (ACM-BCB 2024 - 15th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics).Bar-Ilan University, Tel Aviv University
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
Open Access