Personal profile
Research interests
Systems Biology, Bioinformatics and Molecular Recognition
Our lab combines computational and experimental tools to study molecular interactions and their relationship to biological function and disease.
We analyze biological networks in search of molecular mechanisms that account for the control and dynamics of these networks.
Using clinical data collected from patients with different diseases, we compare the molecular interactions in disease to those observed in normal cells.
We also develop tools to predict molecular interactions, and design molecules that can bind to specific biological macromolecules.
Education/Academic qualification
PhD
Sep 2000 → Sep 2004
Award Date: 1 Sep 2004
Bachelor, Hebrew University of Jerusalem
Oct 1994 → Jun 1998
Award Date: 1 Jun 1998
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Collaborations and top research areas from the last five years
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CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods
The Critical Assessment of Genome Interpretation Consortium, 22 Feb 2024, In: GENOME BIOLOGY. 25, 1, 46 p., 53.Bar-Ilan University, Weizmann Institute of Science, The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Accurate profiling of full-length Fv in highly homologous antibody libraries using UMI tagged short reads
Levin, I., Štrajbl, M., Fastman, Y., Baran, D., Twito, S., Mioduser, J., Keren, A., Fischman, S., Zhenin, M., Nimrod, G., Levitin, N., Mayor, M. B., Gadrich, M. & Ofran, Y., 23 Jun 2023, In: Nucleic acids research. 51, 11, p. E61Research output: Contribution to journal › Article › peer-review
Open Access -
775 Initial results from dose escalation of a phase 1/2 first-in-human, open label study of AU-007, a monoclonal antibody that binds to IL-2 and prevents its binding to CD25, in patients with solid tumors
Vasselli, J., Souza, P. D., Frentzas, S., Weickhardt, A., Wyant, T., Tang, J., Richards, L., Knickerbocker, A., Amit, I. & Ofran, Y., 1 Nov 2022, In: Journal for ImmunoTherapy of Cancer. 10, Suppl 2, p. A805 1 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Computer assisted antibody re-epitoping
Ofran, Y. (Inventor), Nimrod, G. (Inventor), Fischman, S. (Inventor) & Herman, A. (Inventor), 1 Oct 2022, Patent No. US11468969B2Research output: Patent
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De-epitoped alpha gliadin and use of same for the management of celiac disease and gluten sensitivity
Ofran, Y. (Inventor), Ben-David, M. (Inventor), Biran, A. (Inventor), Zakin, S. (Inventor), Garber, O. M. (Inventor) & Chuprin, A. (Inventor), 1 Aug 2022, Patent No. US20220251148A1Research output: Patent