Research output per year
Research output per year
Personal profile
Research interests
We are developing computational and experimental tools to study the underlying mechanisms that govern the adaptive immune response in both natural infection and vaccination. Our main focus is on the role of immunological history. The nature of our work is translational, integrating the design and application of computational approaches with clinical and laboratory studies that provide data for validating and refining our computational tools.
Current Research Directions:
- Host-pathogen co-evolution through the prism of adaptive immunity
- Effects of immunological history on responses to natural infection and vaccination
- Human Leukocyte Antigen (HLA) binding prediction and its applications in vaccine design, HLA-viral interactions, and immunodominance
- Studying the effects of immune mediated pressure on SARS-CoV-2 viral evolution
- Antibody dependant enhancemnet (ADE) in flaviviral infections and vaccines
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Computational Neuroscience, Hebrew University of Jerusalem
Award Date: 1 Oct 2008
Bachelor, Computer Science, Hebrew University of Jerusalem
Award Date: 1 Oct 1999
External positions
Affiliate Investigator, Vaccine and Infectiuos Disease Division
1 Jan 2015 → …
Keywords
- QR180 Immunology
- computational immunology
- systems biology
- immunoinformatics
- Host viral co-evolution
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Neuraminidase-specific antibodies drive differential cross-protection between contemporary FLUBV lineages
Page, C. K., Shepard, J. D., Ray, S. D., Ferguson, J. A., Rodriguez, A. J., Han, J., Jacob, J. C., Rowe-Haas, D. K., Akinpelu, J. Y., Friedman, L. M., Hertz, T., Ward, A. B. & Tompkins, S. M., 28 Mar 2025, In: Science Advances. 11, 13, eadu3344.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
High capacity clinical SARS-CoV-2 molecular testing using combinatorial pooling
Zismanov, S., Shalem, B., Margolin-Miller, Y., Rosin-Grunewald, D., Adar, R., Keren-Naus, A., Amichay, D., Ben-Dor, A., Shemer-Avni, Y., Porgador, A., Shental, N. & Hertz, T., 1 Dec 2024, In: COMMUNICATIONS MEDICINE. 4, 1, 121.Ben-Gurion University of the Negev, Open University of Israel, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access -
Correlates of protection for booster doses of the SARS-CoV-2 vaccine BNT162b2
Hertz, T., Levy, S., Ostrovsky, D., Oppenheimer, H., Zismanov, S., Kuzmina, A., Friedman, L. M., Trifkovic, S., Brice, D., Chun-Yang, L., Cohen-Lavi, L., Shemer-Avni, Y., Cohen-Lahav, M., Amichay, D., Keren-Naus, A., Voloshin, O., Weber, G., Najjar-Debbiny, R., Chazan, B. & McGargill, M. A. & 7 others, , 1 Dec 2023, In: Nature Communications. 14, 1, 4575.Ben-Gurion University of the Negev, Tel Aviv University, Technion - Israel Institute of Technology
Research output: Contribution to journal › Article › peer-review
Open Access -
FLU-LISA (fluorescence-linked immunosorbent assay): high-throughput antibody profiling using antigen microarrays
Levy, S., Abd Alhadi, M., Azulay, A., Kahana, A., Bujanover, N., Gazit, R., McGargill, M. A., Friedman, L. M. & Hertz, T., 1 Mar 2023, In: Immunology and Cell Biology. 101, 3, p. 231-248 18 p.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Induction of bronchus-associated lymphoid tissue is an early life adaptation for promoting human B cell immunity
Matsumoto, R., Gray, J., Rybkina, K., Oppenheimer, H., Levy, L., Friedman, L. M., Khamaisi, M., Meng, W., Rosenfeld, A. M., Guyer, R. S., Bradley, M. C., Chen, D., Atkinson, M. A., Brusko, T. M., Brusko, M., Connors, T. J., Luning Prak, E. T., Hershberg, U., Sims, P. A. & Hertz, T. & 1 others, , 1 Aug 2023, In: Nature Immunology. 24, 8, p. 1370-1381 12 p.Ben-Gurion University of the Negev, University of Haifa
Research output: Contribution to journal › Article › peer-review
Open Access