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Personal profile

Research interests

We are developing computational and experimental tools to study the underlying mechanisms that govern the adaptive immune response in both natural infection and vaccination. Our main focus is on the role of immunological history. The nature of our work is translational, integrating the design and application of computational approaches with clinical and laboratory studies that provide data for validating and refining our computational tools.


Current Research Directions:



  • Host-pathogen co-evolution through the prism of adaptive immunity
  • Effects of immunological history on responses to natural infection and vaccination
  • Human Leukocyte Antigen (HLA) binding prediction and its applications in vaccine design, HLA-viral interactions, and immunodominance
  • Studying the effects of immune mediated pressure on SARS-CoV-2 viral evolution
  • Antibody dependant enhancemnet (ADE) in flaviviral infections and vaccines




Education/Academic qualification

PhD, Computational Neuroscience, Hebrew University of Jerusalem

Award Date: 1 Oct 2008

Bachelor, Computer Science, Hebrew University of Jerusalem

Award Date: 1 Oct 1999

External positions

Affiliate Investigator, Vaccine and Infectiuos Disease Division

1 Jan 2015 → …


  • QR180 Immunology
  • computational immunology
  • systems biology
  • immunoinformatics
  • Host viral co-evolution


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Collaborations and top research areas from the last five years

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