Research output per year
Research output per year
- 32 results
Search results
-
2024
Nrf2 as a potential target for the treatment of epilepsy
Kumar Singh, P. & Shekh-Ahmad, T., 1 Sep 2024, In: Neural Regeneration Research. 19, 9, p. 1865-1866 2 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Drugs acting at TRPM7 channels inhibit seizure-like activity
Khalil, A., Shekh-Ahmad, T., Kovac, S., Wykes, R. C., Horgen, F. D., Fleig, A. & Walker, M. C., Sep 2023, In: Epilepsia Open. 8, 3, p. 1169-1174 6 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
N-oleoyl glycine and N-oleoyl alanine attenuate alcohol self-administration and preference in mice
Shahen-Zoabi, S., Smoum, R., Bingor, A., Grad, E., Nemirovski, A., Shekh-Ahmad, T., Mechoulam, R. & Yaka, R., Dec 2023, In: Translational Psychiatry. 13, 1, 273.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores
Gola, L., Bierhansl, L., Csatári, J., Schroeter, C. B., Korn, L., Narayanan, V., Cerina, M., Abdolahi, S., Speicher, A., Hermann, A. M., König, S., Dinkova-Kostova, A. T., Shekh-Ahmad, T., Meuth, S. G., Wiendl, H., Gorji, A., Pawlowski, M. & Kovac, S., 21 Apr 2023, In: Cellular and Molecular Life Sciences. 80, 5, 127.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Nrf2 is expressed more extensively in neurons than in astrocytes following an acute epileptic seizure in rats
Sandouka, S., Saadi, A., Olowe, R., Singh, P. K. & Shekh-Ahmad, T., May 2023, In: Journal of Neurochemistry. 165, 4, p. 550-562 13 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Nrf2 is predominantly expressed in hippocampal neurons in a rat model of temporal lobe epilepsy
Sandouka, S., Saadi, A., Singh, P. K., Olowe, R. & Shekh-Ahmad, T., 4 Jan 2023, In: Cell and Bioscience. 13, 1, 3.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Repurposing dimethyl fumarate as an antiepileptogenic and disease-modifying treatment for drug-resistant epilepsy
Sandouka, S., Singh, P. K., Saadi, A., Taiwo, R. O., Sheeni, Y., Zhang, T., Deeb, L., Guignet, M., White, S. H. & Shekh-Ahmad, T., 8 Nov 2023, In: Journal of Translational Medicine. 21, 1, 796.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats
Taiwo, R. O., Sandouka, S., Saadi, A., Kovac, S. & Shekh-Ahmad, T., 1 Nov 2023, In: Neuropharmacology. 238, 109670.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2022
On-demand cell-autonomous gene therapy for brain circuit disorders
Qiu, Y., O’Neill, N., Maffei, B., Zourray, C., Almacellas-Barbanoj, A., Carpenter, J. C., Jones, S. P., Leite, M., Turner, T. J., Moreira, F. C., Snowball, A., Shekh-Ahmad, T., Magloire, V., Barral, S., Kurian, M. A., Walker, M. C., Schorge, S., Kullmann, D. M. & Lignani, G., 4 Nov 2022, In: Science. 378, 6619, p. 523-532 10 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Spatial, temporal, and cell-type-specific expression of NADPH Oxidase isoforms following seizure models in rats
Saadi, A., Sandouka, S., Grad, E., Singh, P. K. & Shekh-Ahmad, T., Sep 2022, In: Free Radical Biology and Medicine. 190, p. 158-168 11 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Specific inhibition of NADPH oxidase 2 modifies chronic epilepsy
Singh, P. K., Saadi, A., Sheeni, Y. & Shekh-Ahmad, T., Dec 2022, In: Redox Biology. 58, 102549.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Induction of the nrf2 pathway by sulforaphane is neuroprotective in a rat temporal lobe epilepsy model
Sandouka, S. & Shekh-Ahmad, T., 27 Oct 2021, In: Antioxidants. 10, 11, 1702.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2019
Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy
Shekh-Ahmad, T., Lieb, A., Kovac, S., Gola, L., Wigley, W. C., Abramov, A. Y. & Walker, M. C., Sep 2019, In: Redox Biology. 26, 101278.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Epilepsy gene therapy using an engineered potassium channel
Snowball, A., Chabrol, E., Wykes, R. C., Shekh-Ahmad, T., Cornford, J. H., Lieb, A., Hughes, M. P., Massaro, G., Rahim, A. A., Hashemi, K. S., Kullmann, D. M., Walker, M. C. & Schorge, S., 17 Apr 2019, In: Journal of Neuroscience. 39, 16, p. 3159-3169 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Targeting oxidative stress improves disease outcomes in a rat model of acquired epilepsy
Pauletti, A., Terrone, G., Shekh-Ahmad, T., Salamone, A., Ravizza, T., Rizzi, M., Pastore, A., Pascente, R., Liang, L. P., Villa, B. R., Balosso, S., Abramov, A. Y., van Vliet, E. A., Giudice, E. D., Aronica, E., Patel, M., Walker, M. C. & Vezzani, A., Jul 2019, In: Brain. 142, 7, e39.Research output: Contribution to journal › Article › peer-review
Open Access -
2018
Cannabidiol exerts antiepileptic effects by restoring hippocampal interneuron functions in a temporal lobe epilepsy model
Khan, A. A., Shekh-Ahmad, T., Khalil, A., Walker, M. C. & Ali, A. B., Jun 2018, In: British Journal of Pharmacology. 175, 11, p. 2097-2115 19 p.Research output: Contribution to journal › Article › peer-review
Open Access -
KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy
Shekh-Ahmad, T., Eckel, R., Dayalan Naidu, S., Higgins, M., Yamamoto, M., DInkova-Kostova, A. T., Kovac, S., Abramov, A. Y. & Walker, M. C., 1 May 2018, In: Brain. 141, 5, p. 1390-1403 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2017
A randomized, double-blind, placebo- and risperidone-controlled study on valnoctamide for acute mania
Weiser, M., Levi, L., Levine, S. Z., Bialer, M., Shekh-Ahmad, T., Matei, V., Tiugan, A., Cirjaliu, D., Sava, C., Sinita, E., Zamora, D. & Davis, J. M., Jun 2017, In: Bipolar Disorders. 19, 4, p. 285-294 10 p.Tel Aviv University, University of Haifa, The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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2016
Pharmacokinetic-pharmacodynamic correlation and brain penetration of sec-butylpropylacetamide, a new CNS drug possessing unique activity against status epilepticus
Mawasi, H., Bibi, D., Shekh-Ahmad, T., Shaul, C., Blotnik, S. & Bialer, M., 5 Jul 2016, In: Molecular Pharmaceutics. 13, 7, p. 2492-2496 5 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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2015
Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide - Amide derivatives of valproic acid
Mawasi, H., Shekh-Ahmad, T., Finnell, R. H., Wlodarczyk, B. J. & Bialer, M., 1 May 2015, In: Epilepsy and Behavior. 46, p. 72-78 7 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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The potential of sec-butylpropylacetamide (SPD) and valnoctamide and their individual stereoisomers in status epilepticus
Shekh-Ahmad, T., Mawasi, H., McDonough, J. H., Yagen, B. & Bialer, M., 1 Aug 2015, In: Epilepsy and Behavior. 49, p. 298-302 5 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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2014
Enantioselective pharmacodynamic and pharmacokinetic analysis of two chiral CNS-active carbamate derivatives of valproic acid
Shekh-Ahmad, T., Mawasi, H., McDonough, J. H., Finnell, R. H., Wlodarczyk, B. J., Yavin, E. & Bialer, M., 1 Dec 2014, In: Epilepsia. 55, 12, p. 1944-1952 9 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Sec-Butyl-propylacetamide (SPD) and two of its stereoisomers rapidly terminate paraoxon-induced status epilepticus in rats
Bar-Klein, G., Swissa, E., Kamintsky, L., Shekh-Ahmad, T., Saar-Ashkenazy, R., Hubary, Y., Shrot, S., Stetlander, L., Eisenkraft, A., Friedman, A. & Bialer, M., 1 Dec 2014, In: Epilepsia. 55, 12, p. 1953-1958 6 p.Ben-Gurion University of the Negev, The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Stereoselective anticonvulsant and pharmacokinetic analysis of valnoctamide, a CNS-active derivative of valproic acid with low teratogenic potential
Shekh-Ahmad, T., Hen, N., Yagen, B., McDonough, J. H., Finnell, R. H., Wlodarczyk, B. J. & Bialer, M., Feb 2014, In: Epilepsia. 55, 2, p. 353-361 9 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
2013
A comparative electrographic analysis of the effect of sec-butyl-propylacetamide on pharmacoresistant status epilepticus
Pouliot, W., Bialer, M., Hen, N., Shekh-Ahmad, T., Kaufmann, D., Yagen, B., Ricks, K., Roach, B., Nelson, C. & Dudek, F. E., 2 Feb 2013, In: Neuroscience. 231, p. 145-156 12 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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Comparative steady-state pharmacokinetic evaluation of immediate-release topiramate and USL255, a once-daily extended-release topiramate formulation
Bialer, M., Shekh-Ahmad, T., Braun, T. L. & Halvorsen, M. B., Aug 2013, In: Epilepsia. 54, 8, p. 1444-1452 9 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Stereoselective pharmacodynamic and pharmacokinetic analysis of sec -butylpropylacetamide (SPD), a new CNS-Active derivative of valproic acid with unique activity against status epilepticus
Hen, N., Shekh-Ahmad, T., Yagen, B., McDonough, J. H., Finnell, R. H., Wlodarczyk, B. & Bialer, M., 22 Aug 2013, In: Journal of Medicinal Chemistry. 56, 16, p. 6467-6477 11 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus
Shekh-Ahmad, T., Hen, N., McDonough, J. H., Yagen, B. & Bialer, M., 2013, In: Epilepsia. 54, SUPPL. 6, p. 99-102 4 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Valproic acid derivatives signal for apoptosis and repair in vitro
Neuman, M. G., Nanau, R. M., Shekh-Ahmad, T., Yagen, B. & Bialer, M., Oct 2013, In: Clinical Biochemistry. 46, 15, p. 1532-1537 6 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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2012
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage
White, H. S., Alex, A. B., Pollock, A., Hen, N., Shekh-Ahmad, T., Wilcox, K. S., McDonough, J. H., Stables, J. P., Kaufmann, D., Yagen, B. & Bialer, M., Jan 2012, In: Epilepsia. 53, 1, p. 134-146 13 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Synthesis and anticonvulsant evaluation of dimethylethanolamine analogues of valproic acid and its tetramethylcyclopropyl analogue
Shekh-Ahmad, T., Bialer, M. & Yavin, E., Feb 2012, In: Epilepsy Research. 98, 2-3, p. 238-246 9 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
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2011
Comparative pharmacokinetic analysis of USL255, a new once-daily extended-release formulation of topiramate
Lambrecht, L. J., Shekh-Ahmad, T., Todd, W. M., Halvorsen, M. B. & Bialer, M., Oct 2011, In: Epilepsia. 52, 10, p. 1877-1883 7 p.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review