Sivan Korenblit is a senior Lecturer at the Mina and Everard Faculty of Life Sciences at Bar-Ilan University in Israel. She received her PhD in Biology from the Weizmann Institute of Sciences in Rehovot and started her research the field of genetics of aging in the early 2000s at UCSF. She joined the Faculty of Life Sciences at Bar-Ilan University in 2009 as a senior lecturer. Her areas of interest include: Aging, Gerentalogy, Genetics ,Cell biology, Protein homeostasis, Cellular stress responses and the endoplasmic reticulum.

Research Areas:

Human aging is accompanied by an overall decline in physiological function and an increase in the incidence of age-related diseases. My main research interest is to identify what, at the molecular level, delays aging and links aging to age-related disease. In particular, I am interested in the link between aging, age-related disease and ER stress response.The long-term goal of my future lab will be to learn how to control the rate of aging and the efficiency of the ER stress response as means to treat age-related diseases. To achieve this I will study how reducing insulin/IGF-1 signaling controls aging and ER stress response and, in turn, how do these affect age-related disease models. I propose to explore these questions utilizing the model organism C. elegans, by following these specific aims:

1) Explore and delineate important molecular mechanisms that underlie each of these processes (i.e. what genes/pathways control the rate of aging, what genes/pathways improve ER stress response).

2)  Study how aging pathways and ER stress pathways interact and impact each other.

3) Study how manipulation of aging pathways and ER stress pathways affect age-related disease models.