Research output per year
Research output per year
Personal profile
Research interests
At the Ilouz lab we are focusing on investigating signaling pathways regulated by protein kinases in health and disease. Our ultimate goal is to understand the molecular and cellular mechanisms by which
supramolecular complexes are assembled and spatiotemporally regulated to achieve accurate and specific responses. We are expanding our knowledge from the atomic level resolution, by determining 3D structures of protein complexes, to the cellular and tissue levels, by analyzing perturbations in signaling pathways in disease mouse models or human tissues. Linking molecular and cellular events with physiological function may lead us to an identification of novel therapeutic targets for intervention.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
PhD, Tel Aviv University
Oct 2003 → Sep 2008
Award Date: 30 Sep 2008
Master, Tel Aviv University
Oct 2001 → Sep 2003
Award Date: 30 Sep 2003
Bachelor, Tel Aviv University
Oct 1996 → Sep 2000
Award Date: 30 Sep 2000
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species
Benjamin-Zukerman, T., Shimon, G., Gaine, M. E., Dakwar, A., Peled, N., Aboraya, M., Masri-Ismail, A., Safadi-Safa, R., Solomon, M., Lev-Ram, V., Rissman, R. A., Mayrhofer, J. E., Raffeiner, A., Mol, M. O., Argue, B. M. R., McCool, S., Doan, B., van Swieten, J., Stefan, E. & Abel, T. & 1 others, , 4 Nov 2024, In: Brain. 147, 11, p. 3890-3905 16 p.Research output: Contribution to journal › Article › peer-review
Open Access -
A conserved arginine within the αC-helix of Erk1/2 is a latch of autoactivation and of oncogenic capabilities
Soudah, N., Baskin, A., Smorodinsky-Atias, K., Beenstock, J., Ganon, Y., Hayouka, R., Aboraya, M., Livnah, O., Ilouz, R. & Engelberg, D., Sep 2023, In: Journal of Biological Chemistry. 299, 9, 105072.The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Protein Kinase A in Human Retina: Differential Localization of Cβ, Cα, RIIα, and RIIβ in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits
Roa, J. N., Ma, Y., Mikulski, Z., Xu, Q., Ilouz, R., Taylor, S. S. & Skowronska-Krawczyk, D., 18 Nov 2021, In: Frontiers in Molecular Neuroscience. 14, 782041.Research output: Contribution to journal › Article › peer-review
Open Access -
Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling
Bachmann, V. A., Mayrhofer, J. E., Ilouz, R., Tschaikner, P., Raffeiner, P., Röck, R., Courcelles, M., Apelt, F., Lu, T. W., Baillie, G. S., Thibault, P., Aanstad, P., Stelzl, U., Taylor, S. S. & Stefan, E., 12 Jul 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 28, p. 7786-7791 6 p.Research output: Contribution to journal › Article › peer-review
Open Access -
D-AKAP2:PKA RII:PDZK1 ternary complex structure: Insights from the nucleation of a polyvalent scaffold
Sarma, G. N., Moody, I. S., Ilouz, R., Phan, R. H., Sankaran, B., Hall, R. A. & Taylor, S. S., 1 Jan 2015, In: Protein Science. 24, 1, p. 105-116 12 p.Research output: Contribution to journal › Article › peer-review
Open Access