Research output per year
Research output per year
Personal profile
Research interests
Senior Lecturer (Assistant Professor) Principal Investigator, Laboratory for Host-Microbiome Interactions.
The intestinal immune system and the microbiome: communication networks and decision-making processes
We study the cellular, molecular and genetic mechanisms that facilitate communication between cells of the immune system and their environment in the gut - the gut microbes (microbiome), the enteric nervous system, and intestinal epithelium, etc…
We aim to understand how these intercellular communication networks control immunological decision-making processes, between inflammation and immunological tolerance, in health and in autoimmune and chronic inflammatory diseases (such as inflammatory bowel diseases).
We combine microscopy, genomics and molecular biology together with a unique gut organ culture system, that allow dissecting these host-environment interactions in real-time, ex-vivo (Yissachar et al., Cell, 2017).
In addition, we combine principles of systems biology, to understand how cells of the immune system process environmental signals in real-time (Yissachar et al., Molecular Cell, 2013).
Education/Academic qualification
PhD, Bar-Ilan University
Oct 2004 → Sep 2008
Award Date: 30 Sep 2008
Master, Bar-Ilan University
Oct 2003 → Sep 2004
Award Date: 30 Sep 2004
Bachelor, Bar-Ilan University
Oct 2000 → Sep 2003
Award Date: 30 Sep 2003
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Collaborations and top research areas from the last five years
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Cell-autonomous innate immunity by proteasome-derived defence peptides
Goldberg, K., Lobov, A., Antonello, P., Shmueli, M. D., Yakir, I., Weizman, T., Ulman, A., Sheban, D., Laser, E., Kramer, M. P., Shteinvil, R., Chen, G., Ibraheem, A., Sysoeva, V., Fishbain-Yoskovitz, V., Mohapatra, G., Abramov, A., Shimshi, S., Ogneva, K. & Nandy, M. & 10 others, , 5 Mar 2025, In: Nature. 639, 8056, p. 1032-1041 27 p., 836.Weizmann Institute of Science, Bar-Ilan University, The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
From microbiota to menu: predicting individual responses to dietary components
Romano-Zadaka, H. & Yissachar, N., 26 Feb 2025, (Published Online) In: Gut. gutjnl-2025-334712.Research output: Contribution to journal › Comment/debate
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Colon impairments and inflammation driven by an altered gut microbiota leads to social behavior deficits rescued by hyaluronic acid and celecoxib
Agranyoni, O., Sur, D., Amidror, S., Shidlovsky, N., Bagaev, A., Yissachar, N., Pinhasov, A. & Navon-Venezia, S., Dec 2024, In: BMC Medicine. 22, 1, 182.Ariel University, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access -
Ex vivo intestinal permeability assay (X-IPA) for tracking barrier function dynamics
Bootz-Maoz, H., Simon, A., Del Mare-Roumani, S., Bennet, Y., Toister, E., Romano, H., Zheng, D., Amidror, S., Elinav, E. & Yissachar, N., 3 Jul 2023, In: npj Biofilms and Microbiomes. 9, 1, 6 p., 44.Weizmann Institute of Science, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access -
Diet-induced modifications to human microbiome reshape colonic homeostasis in irritable bowel syndrome
Bootz-Maoz, H., Pearl, A., Melzer, E., Malnick, S., Sharon, E., Bennet, Y., Tsentsarevsky, R., Abuchatzera, S., Amidror, S., Aretz, E., Azriel, S., Gam Ze Letova, C., Naama, M., Shoval, I., Yaron, O., Karako-Lampert, S., Bel, S. & Yissachar, N., 15 Nov 2022, In: Cell Reports. 41, 7, 111657.Research output: Contribution to journal › Article › peer-review
Open Access