Natalia Freund

2024

Intranasal Multiepitope PD-L1-siRNA-Based Nanovaccine: The Next-Gen COVID-19 Immunotherapy

Acúrcio, R. C., Kleiner, R., Vaskovich-Koubi, D., Carreira, B., Liubomirski, Y., Palma, C., Yeheskel, A., Yeini, E., Viana, A. S., Ferreira, V., Araújo, C., Mor, M., Freund, N. T., Bacharach, E., Gonçalves, J., Toister-Achituv, M., Fabregue, M., Matthieu, S., Guerry, C., Zarubica, A., & 3 othersAviel-Ronen, S., Florindo, H. F. & Satchi-Fainaro, R., 28 Oct 2024, In: Advanced Science. 11, 40, 2404159.

Ariel University, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

2023

Evaluation of the Ability of AlphaFold to Predict the Three-Dimensional Structures of Antibodies and Epitopes

Polonsky, K., Pupko, T. & Freund, N. T., 15 Nov 2023, In: Journal of Immunology. 211, 10, p. 1578-1588 11 p.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Monkeypox infection elicits strong antibody and B cell response against A35R and H3L antigens

Yefet, R., Friedel, N., Tamir, H., Polonsky, K., Mor, M., Cherry-Mimran, L., Taleb, E., Hagin, D., Sprecher, E., Israely, T. & Freund, N. T., 17 Feb 2023, In: iScience. 26, 2, p. 105957 105957.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Qualitative monitoring of SARS-CoV-2 mRNA vaccination in humans using droplet microfluidics

Broketa, M., Sokal, A., Mor, M., Canales-Herrerias, P., Perima, A., Meola, A., Fernández, I., Iannascoli, B., Chenon, G., Vandenberghe, A., Languille, L., Michel, M., Godeau, B., Gallien, S., Melica, G., Backovic, M., Rey, F. A., Baudry, J., Freund, N. T., Mahévas, M., & 1 othersBruhns, P., 10 Jul 2023, In: JCI Insight. 8, 13, e166602.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

β2-adrenergic signaling promotes higher-affinity B cells and antibodies

Ben-Shalom, N., Sandbank, E., Abramovitz, L., Hezroni, H., Levine, T., Trachtenberg, E., Fogel, N., Mor, M., Yefet, R., Stoler-Barak, L., Hagin, D., Nakai, A., Noda, M., Suzuki, K., Shulman, Z., Ben-Eliyahu, S. & Freund, N. T., Oct 2023, In: Brain, Behavior, and Immunity. 113, p. 66-82 17 p.

Tel Aviv University, Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

2022

Anti-TNFα Treatment Impairs Long-Term Immune Responses to COVID-19 mRNA Vaccine in Patients with Inflammatory Bowel Diseases

Israeli, R. COVID. V., 26 Jul 2022, In: Vaccines. 10, 8, 1186.

Bar-Ilan University, Ariel University, Ben-Gurion University of the Negev, Technion - Israel Institute of Technology, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies

Li, R., Mor, M., Ma, B., Clark, A. E., Alter, J., Werbner, M., Lee, J. C., Leibel, S. L., Carlin, A. F., Dessau, M., Gal-Tanamy, M., Croker, B. A., Xiang, Y. & Freund, N. T., Dec 2022, In: Communications Biology. 5, 1, 789.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Lower Serologic Response to COVID-19 mRNA Vaccine in Patients With Inflammatory Bowel Diseases Treated With Anti-TNFα

IsRaeli, RE. COVID. V., 1 Feb 2022, In: Gastroenterology. 162, 2, p. 454-467 14 p.

Tel Aviv University, Technion - Israel Institute of Technology, Ariel University, Ben-Gurion University of the Negev, Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Open Access

Tumor-reactive antibodies evolve from non-binding and autoreactive precursors

Mazor, R. D., Nathan, N., Gilboa, A., Stoler-Barak, L., Moss, L., Solomonov, I., Hanuna, A., Divinsky, Y., Shmueli, M. D., Hezroni, H., Zaretsky, I., Mor, M., Golani, O., Sabah, G., Jakobson-Setton, A., Yanichkin, N., Feinmesser, M., Tsoref, D., Salman, L., Yeoshoua, E., & 10 othersPeretz, E., Erlich, I., Mendelson Cohen, N., Gershoni, J. M., Freund, N., Merbl, Y., Yaari, G., Eitan, R., Sagi, I. & Shulman, Z., 31 Mar 2022, In: Cell. 185, 7, p. 1208-1222 37 p.

Weizmann Institute of Science, Tel Aviv University, Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Open Access

File

2021

Antibodies: what makes us stronger

Freund, N. T., 2021, In: Human Vaccines and Immunotherapeutics. 17, 10, p. 3551-3553 3 p.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Human antibodies targeting a Mycobacterium transporter protein mediate protection against tuberculosis

Watson, A., Li, H., Ma, B., Weiss, R., Bendayan, D., Abramovitz, L., Ben-Shalom, N., Mor, M., Pinko, E., Bar Oz, M., Wang, Z., Du, F., Lu, Y., Rybniker, J., Dahan, R., Huang, H., Barkan, D., Xiang, Y., Javid, B. & Freund, N. T., 1 Dec 2021, In: Nature Communications. 12, 1, 11 p., 602.

Tel Aviv University, Weizmann Institute of Science, The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Open Access

Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunity

Hagin, D., Freund, T., Navon, M., Halperin, T., Adir, D., Marom, R., Levi, I., Benor, S., Alcalay, Y. & Freund, N. T., Sep 2021, In: Journal of Allergy and Clinical Immunology. 148, 3, p. 739-749 11 p.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Multi-clonal SARS-CoV-2 neutralization by antibodies isolated from severe COVID-19 convalescent donors

Mor, M., Werbner, M., Alter, J., Safra, M., Chomsky, E., Lee, J. C., Hada-Neeman, S., Polonsky, K., Nowell, C. J., Clark, A. E., Roitburd-Berman, A., Ben-Shalom, N., Navon, M., Rafael, D., Kiner, E., Griffis, E. R., Gershoni, J. M., Kobiler, O., Leibel, S. L., Zimhony, O., & 7 othersCarlin, A. F., Yaari, G., Dessau, M., Gal-Tanamy, M., Hagin, D., Croker, B. A. & Freund, N. T., Feb 2021, In: PLoS Pathogens. 17, 2, e1009165.

Tel Aviv University, Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Open Access

Rapid seroconversion and persistent functional IgG antibodies in severe COVID-19 patients correlates with an IL-12p70 and IL-33 signature

Munitz, A., Edry-Botzer, L., Itan, M., Tur-Kaspa, R., Dicker, D., Marcoviciu, D., Goren, M. G., Mor, M., Lev, S., Gottesman, T., Muhsen, K., Cohen, D., Stein, M., Qimron, U., Freund, N. T., Wine, Y. & Gerlic, M., 1 Dec 2021, In: Scientific Reports. 11, 1, 3461.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Unleashing natural antibodies against HIV-1

Ben-Shalom, N. & Freund, N. T., 9 Jun 2021, In: Cell Host and Microbe. 29, 6, p. 849-851 3 p.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

2018

Structural characterization of a highly-potent V3-glycan broadly neutralizing antibody bound to natively-glycosylated HIV-1 envelope

Barnes, C. O., Gristick, H. B., Freund, N. T., Escolano, A., Lyubimov, A. Y., Hartweger, H., West, A. P., Cohen, A. E., Nussenzweig, M. C. & Bjorkman, P. J., 1 Dec 2018, In: Nature Communications. 9, 1, 1251.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

2017

Asymmetric recognition of HIV-1 envelope trimer by V1V2 loop-targeting antibodies

Wang, H., Gristick, H. B., Scharf, L., West, A. P., Galimidi, R. P., Seaman, M. S., Freund, N. T., Nussenzweig, M. C. & Bjorkman, P. J., 26 May 2017, In: eLife. 6, e27389.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller

Freund, N. T., Wang, H., Scharf, L., Nogueira, L., Horwitz, J. A., Bar-On, Y., Golijanin, J., Sievers, S. A., Sok, D., Cai, H., Lorenzi, J. C. C., Halper-Stromberg, A., Toth, I., Piechocka-Trocha, A., Gristick, H. B., Van Gils, M. J., Sanders, R. W., Wang, L. X., Seaman, M. S., Burton, D. R., & 5 othersGazumyan, A., Walker, B. D., West, A. P., Bjorkman, P. J. & Nussenzweig, M. C., 18 Jan 2017, In: Science Translational Medicine. 9, 373, eaal2144.

Research output: Contribution to journal › Article › peer-review

Open Access

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo

Medina-Ramírez, M., Garces, F., Escolano, A., Skog, P., de Taeye, S. W., Del Moral-Sanchez, I., McGuire, A. T., Yasmeen, A., Behrens, A. J., Ozorowski, G., van den Kerkhof, T. L. G. M., Freund, N. T., Dosenovic, P., Hua, Y., Gitlin, A. D., Cupo, A., van der Woude, P., Golabek, M., Sliepen, K., Blane, T., & 13 othersKootstra, N., van Breemen, M. J., Pritchard, L. K., Stanfield, R. L., Crispin, M., Ward, A. B., Stamatatos, L., Klasse, P. J., Moore, J. P., Nemazee, D., Nussenzweig, M. C., Wilson, I. A. & Sanders, R. W., 2017, In: Journal of Experimental Medicine. 214, 9, p. 2573-2590 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2016

HIV Vaccine Design to Target Germline Precursors of Glycan-Dependent Broadly Neutralizing Antibodies

Steichen, J. M., Kulp, D. W., Tokatlian, T., Escolano, A., Dosenovic, P., Stanfield, R. L., McCoy, L. E., Ozorowski, G., Hu, X., Kalyuzhniy, O., Briney, B., Schiffner, T., Garces, F., Freund, N. T., Gitlin, A. D., Menis, S., Georgeson, E., Kubitz, M., Adachi, Y., Jones, M., & 9 othersMutafyan, A. A., Yun, D. S., Mayer, C. T., Ward, A. B., Burton, D. R., Wilson, I. A., Irvine, D. J., Nussenzweig, M. C. & Schief, W. R., 20 Sep 2016, In: Immunity. 45, 3, p. 483-496 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

Escolano, A., Steichen, J. M., Dosenovic, P., Kulp, D. W., Golijanin, J., Sok, D., Freund, N. T., Gitlin, A. D., Oliveira, T., Araki, T., Lowe, S., Chen, S. T., Heinemann, J., Yao, K. H., Georgeson, E., Saye-Francisco, K. L., Gazumyan, A., Adachi, Y., Kubitz, M., Burton, D. R., & 2 othersSchief, W. R. & Nussenzweig, M. C., 8 Sep 2016, In: Cell. 166, 6, p. 1445-1458.e12

Research output: Contribution to journal › Article › peer-review

Open Access

Specifically modified Env immunogens activate B-cell precursors of broadly neutralizing HIV-1 antibodies in transgenic mice

McGuire, A. T., Gray, M. D., Dosenovic, P., Gitlin, A. D., Freund, N. T., Petersen, J., Correnti, C., Johnsen, W., Kegel, R., Stuart, A. B., Glenn, J., Seaman, M. S., Schief, W. R., Strong, R. K., Nussenzweig, M. C. & Stamatatos, L., 24 Feb 2016, In: Nature Communications. 7, 10618.

Research output: Contribution to journal › Article › peer-review

Open Access

2015

Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient

Freund, N. T., Scheid, J. F., Mouquet, H. & Nussenzweig, M. C., 2015, In: Journal of Immunological Methods. 418, p. 61-65 5 p.

Research output: Contribution to journal › Article › peer-review

A New Glycan-Dependent CD4-Binding Site Neutralizing Antibody Exerts Pressure on HIV-1 In Vivo

Freund, N. T., Horwitz, J. A., Nogueira, L., Sievers, S. A., Scharf, L., Scheid, J. F., Gazumyan, A., Liu, C., Velinzon, K., Goldenthal, A., Sanders, R. W., Moore, J. P., Bjorkman, P. J., Seaman, M. S., Walker, B. D., Klein, F. & Nussenzweig, M. C., 2015, In: PLoS Pathogens. 11, 10, e1005238.

Research output: Contribution to journal › Article › peer-review

Open Access

Immunization for HIV-1 Broadly Neutralizing Antibodies in Human Ig Knockin Mice

Dosenovic, P., Von Boehmer, L., Escolano, A., Jardine, J., Freund, N. T., Gitlin, A. D., McGuire, A. T., Kulp, D. W., Oliveira, T., Scharf, L., Pietzsch, J., Gray, M. D., Cupo, A., Van Gils, M. J., Yao, K. H., Liu, C., Gazumyan, A., Seaman, M. S., Björkman, P. J., Sanders, R. W., & 4 othersMoore, J. P., Stamatatos, L., Schief, W. R. & Nussenzweig, M. C., 20 Jun 2015, In: Cell. 161, 7, p. 1505-1515 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Reconstitution of the receptor-binding motif of the SARS coronavirus

Freund, N. T., Roitburd-Berman, A., Sui, J., Marasco, W. A. & Gershoni, J. M., 2015, In: Protein Engineering, Design and Selection. 28, 12, p. 567-575 9 p.

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Open Access

Freund Natalia

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