Kosloff Mickey

Research output

Research output per year 2011 2018 2019 2021 2023

• 23 Article
• 2 Comment/debate
• 1 Review article

Research output per year

Research output per year

Search results

• 2023

  Gene expression meta-analysis in patients with schizophrenia reveals up-regulation of RGS2 and RGS16 in Brodmann Area 10

  Shriebman, Y., Yitzhaky, A., Kosloff, M. & Hertzberg, L., Jan 2023, In: European Journal of Neuroscience. 57, 2, p. 360-372 13 p.

  Weizmann Institute of Science, University of Haifa, Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • Schizophrenia 100%
  • Meta-Analysis 91%
  • Up-Regulation 88%
  • Gene Expression 73%
  • G-Protein-Coupled Receptors 35%
• 2022

  Evolution of homo-oligomerization of methionine S-adenosyltransferases is replete with structure–function constrains

  Kleiner, D., Shapiro Tuchman, Z., Shmulevich, F., Shahar, A., Zarivach, R., Kosloff, M. & Bershtein, S., 1 Jul 2022, In: Protein Science. 31, 7, e4352.

  Ben-Gurion University of the Negev, University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Methionine Adenosyltransferase 100%
  • Methionine 62%
  • Neisseria gonorrhoeae 24%
  • Hydrophobic and Hydrophilic Interactions 22%
  • Catalytic Domain 18%
• 2021

  A guide to adhesion GPCR research: exploring the structure, function and clinic relevance of adhesion GPCRs using multi-disciplinary approaches

  Liebscher, I., Cevheroğlu, O., Hsiao, C. C., Maia, A. F., Schihada, H., Scholz, N., Soave, M., Spiess, K., Trajković, K., Kosloff, M. & Prömel, S., 2021, In: FEBS Journal. 289, 24, p. 1-21 21 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • G-Protein-Coupled Receptors 100%
  • Reaction Yield 40%
  • Surface 31%
  • Cell Surface Receptors 17%
  • Research Design 13%

• Ectopic activation of GABA_B receptors inhibits neurogenesis and metamorphosis in the cnidarian Nematostella vectensis

  Levy, S., Brekhman, V., Bakhman, A., Malik, A., Sebé-Pedrós, A., Kosloff, M. & Lotan, T., Jan 2021, In: Nature Ecology and Evolution. 5, 1, p. 111-121 11 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  • Nematostella vectensis 100%
  • neurogenesis 84%
  • metamorphosis 78%
  • Cnidaria 73%
  • gamma-aminobutyric acid 68%

• Residue-level determinants of RGS R4 subfamily GAP activity and specificity towards the G_i subfamily

  Asli, A., Higazy-Mreih, S., Avital-Shacham, M. & Kosloff, M., Sep 2021, In: Cellular and Molecular Life Sciences. 78, 17-18, p. 6305-6318 14 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • GTP-Binding Protein Regulators 100%
  • Protein Domains 40%
  • GTP-Binding Proteins 40%
  • GTP Phosphohydrolases 30%
  • RGS Proteins 20%

• Structural design principles for specific ultra-high affinity interactions between colicins/pyocins and immunity proteins

  Shushan, A. & Kosloff, M., Dec 2021, In: Scientific Reports. 11, 1, p. 1-15 3789.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • colicin immunity proteins 100%
  • Pyocins 86%
  • Colicins 74%
  • Immunity 41%
  • Amino Acid Motifs 25%
• 2020

  The European Research Network on Signal Transduction (ERNEST): Toward a Multidimensional Holistic Understanding of G Protein-Coupled Receptor Signaling

  Sommer, M. E., Selent, J., Carlsson, J., De Graaf, C., Gloriam, D. E., Keseru, G. M., Kosloff, M., Mordalski, S., Rizk, A., Rosenkilde, M. M., Sotelo, E., Tiemann, J. K. S., Tobin, A., Vardjan, N., Waldhoer, M. & Kolb, P., 10 Apr 2020, In: ACS Pharmacology and Translational Science. 3, 2, p. 361-370 10 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • G-Protein-Coupled Receptors 100%
  • Signal Transduction 77%
  • Drug Design 28%
  • Ligands 17%
  • Growth 12%
• 2019

  Residue-level determinants of angiopoietin-2 interactions with its receptor Tie2

  Bakhman, A., Rabinovich, E., Shlamkovich, T., Papo, N. & Kosloff, M., 1 Mar 2019, In: Proteins: Structure, Function and Bioinformatics. 87, 3, p. 185-197 13 p.

  Ben-Gurion University of the Negev, University of Haifa

  Research output: Contribution to journal › Article › peer-review

  • TIE-2 Receptor 100%
  • Angiopoietin-2 87%
  • Receptor Protein-Tyrosine Kinases 14%
  • Tyrosine 14%
  • Mutation 13%

• RGS6 and RGS7 Discriminate between the Highly Similar Gα_i and Gα_o Proteins Using a Two-Tiered Specificity Strategy

  Israeli, R., Asli, A., Avital-Shacham, M. & Kosloff, M., 9 Aug 2019, In: Journal of Molecular Biology. 431, 17, p. 3302-3311 10 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • Protein Domains 33%
  • GTP-Binding Proteins 33%
  • RGS Proteins 25%
  • Proteins 24%

• Structural design principles that underlie the multi-specific interactions of Gα _q with dissimilar partners

  Navot, S. & Kosloff, M., 1 Dec 2019, In: Scientific Reports. 9, 1, p. 1-10 6898.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • G-Protein-Coupled Receptor Kinase 2 100%
  • GTPase-Activating Proteins 57%
  • Type C Phospholipases 47%
  • RGS Proteins 32%
  • Rho Guanine Nucleotide Exchange Factors 32%
• 2018

  Interplay between negative and positive design elements in Gα helical domains of G proteins determines interaction specificity toward RGS2

  Kasom, M., Gharra, S., Sadiya, I., Avital-Shacham, M. & Kosloff, M., 25 Jul 2018, In: Biochemical Journal. 475, 14, p. 2293-2304 12 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  • RGS Proteins 100%
  • GTP-Binding Proteins 96%
  • GTP Phosphohydrolases 74%
  • GTP-Binding Protein Regulators 48%
  • Protein 40%

• Neofunctionalization in ligand binding sites of ant olfactory receptors

  Saad, R., Cohanim, A. B., Kosloff, M. & Privman, E., 1 Sep 2018, In: Genome Biology and Evolution. 10, 9, p. 2490-2500 11 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Odorant Receptors 100%
  • Ants 99%
  • olfactory receptors 93%
  • ant 85%
  • ligand 75%

• Refinement of the endogenous epitope tagging technology allows the identification of a novel NRAS binding partner in melanoma

  Alon, M., Emmanuel, R., Qutob, N., Bakhman, A., Peshti, V., Brodezki, A., Bassan, D., Kosloff, M. & Samuels, Y., 1 Sep 2018, In: Pigment Cell and Melanoma Research. 31, 5, p. 641-648 8 p.

  Weizmann Institute of Science, University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Epitope 100%
  • Epitopes 84%
  • Melanoma 81%
  • Technology 64%
  • Systems Integration 28%

• RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells

  Qutob, N., Masuho, I., Alon, M., Emmanuel, R., Cohen, I., Di Pizio, A., Madore, J., Elkahloun, A., Ziv, T., Levy, R., Gartner, J. J., Hill, V. K., Lin, J. C., Hevroni, Y., Greenberg, P., Brodezki, A., Rosenberg, S. A., Kosloff, M., Hayward, N. K., Admon, A., & 4 othersNiv, M. Y., Scolyer, R. A., Martemyanov, K. A. & Samuels, Y., 12 Jan 2018, In: Scientific Reports. 8, 1, p. 1-10 10 p., 653.

  Weizmann Institute of Science, University of Haifa, Technion - Israel Institute of Technology, The Hebrew University of Jerusalem

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Melanoma 100%
  • Neoplasms 38%
  • Exome 36%
  • Valine 35%
  • Protein Stability 35%

• Structural motifs in the RGS RZ subfamily combine to attenuate interactions with Gα subunits

  Salem-Mansour, D., Asli, A., Avital-Shacham, M. & Kosloff, M., 18 Sep 2018, In: Biochemical and Biophysical Research Communications. 503, 4, p. 2736-2741 6 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  • GTP-Binding Protein Regulators 100%
  • GTPase-Activating Proteins 90%
  • Protein 27%
  • RGS Proteins 25%
  • Heterotrimeric GTP-Binding Proteins 22%

• “Disruptor” residues in the regulator of g protein signaling (RGS) R12 subfamily attenuate the inactivation of g subunits

  Asli, A., Sadiya, I., Avital-Shacham, M. & Kosloff, M., 12 Jun 2018, In: Science Signaling. 11, 534, p. 1-10 eaan3677.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RGS Proteins 100%
  • GTP-Binding Protein Regulators 96%
  • Protein 93%
  • Proteins 83%
  • Heterotrimeric GTP-Binding Proteins 43%
• 2017

  Engineering a monomeric variant of macrophage colony-stimulating factor (M-CSF) that antagonizes the c-FMS receptor

  Zur, Y., Rosenfeld, L., Bakhman, A., Ilic, S., Hayun, H., Shahar, A., Akabayov, B., Kosloff, M., Levaot, N. & Papo, N., 1 Aug 2017, In: Biochemical Journal. 474, 15, p. 2601-2617 17 p.

  Ben-Gurion University of the Negev, University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Colony Stimulating Factor 100%
  • Macrophage Colony-Stimulating Factor 81%
  • Dimerization 75%
  • Osteoclasts 69%
  • Ligands 47%

• Identifying Residues that Determine SCF Molecular-Level Interactions through a Combination of Experimental and In silico Analyses

  Rabinovich, E., Heyne, M., Bakhman, A., Kosloff, M., Shifman, J. M. & Papo, N., 6 Jan 2017, In: Journal of Molecular Biology. 429, 1, p. 97-114 18 p.

  Ben-Gurion University of the Negev, University of Haifa, The Hebrew University of Jerusalem

  Research output: Contribution to journal › Article › peer-review

  • Stem Cell Factor 100%
  • Computer Simulation 77%
  • Epitope Mapping 18%
  • Mutation 15%
  • Yeasts 11%
• 2013

  From protein structure to function via computational tools and approaches

  Kolodny, R. & Kosloff, M., Apr 2013, In: Israel Journal of Chemistry. 53, 3-4, p. 147-156 10 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  • Protein Structure 100%
  • Protein 42%
• 2012

  Compartmentalization and Ca²⁺ buffering are essential for prevention of light-induced retinal degeneration

  Weiss, S., Kohn, E., Dadon, D., Katz, B., Peters, M., Lebendiker, M., Kosloff, M., Colley, N. J. & Minke, B., 17 Oct 2012, In: Journal of Neuroscience. 32, 42, p. 14696-14708 13 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Photoreceptor Cells 100%
  • Retinal Degeneration 97%
  • Cell Body 79%
  • Light 56%
  • Buffers 48%

• Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia

  Cohen, S. P., Buckley, B. K., Kosloff, M., Garland, A. L., Bosch, D. E., Cheng Gang, J., Radhakrishna, H., Brown, M. D., Willard, F. S., Arshavsky, V. Y., Tarran, R., Siderovski, D. P. & Kimple, A. J., 7 Dec 2012, In: Journal of Biological Chemistry. 287, 50, p. 41706-41719 14 p.

  University of Haifa

  Research output: Contribution to journal › Article › peer-review

  • Lingual 100%
  • GTP-Binding Protein Regulators 86%
  • Tongue 54%
  • Epithelium 44%
  • Signal Transduction 25%
• 2011

  Cooperative phosphoinositide and peptide binding by PSD-95/discs large/ZO-1 (PDZ) domain of polychaetoid, Drosophila zonulin

  Ivarsson, Y., Wawrzyniak, A. M., Wuytens, G., Kosloff, M., Vermeiren, E., Raport, M. & Zimmermann, P., 30 Dec 2011, In: Journal of Biological Chemistry. 286, 52, p. 44669-44678 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • zonulin 100%
  • phosphatidylinositol 5-phosphate 83%
  • Phosphoinositide 77%
  • Phosphatidylinositols 60%
  • Drosophila 53%

• Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions

  Kosloff, M., Travis, A. M., Bosch, D. E., Siderovski, D. P. & Arshavsky, V. Y., Jul 2011, In: Nature Structural and Molecular Biology. 18, 7, p. 846-853 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RGS Proteins 100%
  • GTP-Binding Proteins 64%
  • GTP-Binding Protein Regulators 41%
  • Protein Domains 9%
  • Mutation 5%