Research output per year
Research output per year
Personal profile
Research interests
The lab studies the genetic and cellular function of the brain. The lab main research interests are neurodevelopment and neuroendocrinology with special emphasis on sleep and sleep disorders. To understand these processes, we combine the use of genetic manipulations, real-time 2-photon imaging of single molecules, organelles, and neurons, as well as video-tracking of behavior in live zebrafish. The zebrafish is a simple vertebrate with evolutionary conserved organization of the central nervous system. This unique transparent model is amenable for live imaging and highthroughput genetic and pharmacological experiments.
Our general goal is to link gene function with the development and plasticity of neuronal circuits that regulate specific behavior. In order to understand human brain disorders, we develop several zebrafish models. The function of genes and neuronal circuits is determined using loss-of-function (CRISPR-mediated genome editing as well as genetic silencing and ablation of a specific neuronal population) and gain-of-function (transposon-mediated transgenesis, pharmacology and optogenetics) experiments.
Education/Academic qualification
PhD, Bar-Ilan University
Jan 2001 → Jan 2005
Award Date: 1 Jan 2005
Master, Bar-Ilan University
Jan 2000 → Jan 2001
Award Date: 1 Jan 2001
Bachelor, Bar-Ilan University
Jan 1997 → Jan 2000
Award Date: 1 Jan 2000
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Collaborations and top research areas from the last five years
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CLOCK evolved in cnidaria to synchronize internal rhythms with diel environmental cues
Aguillon, R., Rinsky, M., Simon-Blecher, N., Doniger, T., Appelbaum, L. & Levy, O., 14 May 2024, In: eLife. 12Research output: Contribution to journal › Article › peer-review
Open Access -
Single-Cell Profiling Uncovers Evolutionary Divergence of Hypocretin/Orexin Neuronal Subpopulations
Sagi, D., Tibi, M., Admati, I., Lerer-Goldshtein, T., Hochgerner, H., Zeisel, A. & Appelbaum, L., 4 Sep 2024, In: Journal of Neuroscience. 44, 36, e0095242024.Research output: Contribution to journal › Article › peer-review
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Venom trade-off shapes interspecific interactions, physiology, and reproduction
Surm, J. M., Birch, S., Macrander, J., Jaimes-Becerra, A., Fridrich, A., Aharoni, R., Rozenblat, R., Sharabany, J., Appelbaum, L., Reitzel, A. M. & Moran, Y., 15 Mar 2024, In: Science Advances. 10, 11, eadk3870.Bar-Ilan University, The Hebrew University of Jerusalem
Research output: Contribution to journal › Article › peer-review
Open Access -
Radial astrocyte synchronization modulates the visual system during behavioral-state transitions
Uribe-Arias, A., Rozenblat, R., Vinepinsky, E., Marachlian, E., Kulkarni, A., Zada, D., Privat, M., Topsakalian, D., Charpy, S., Candat, V., Nourin, S., Appelbaum, L. & Sumbre, G., 20 Dec 2023, In: Neuron. 111, 24, p. 4040-4057.e6Research output: Contribution to journal › Article › peer-review
Open Access -
A Zebrafish Model for a Rare Genetic Disease Reveals a Conserved Role for FBXL3 in the Circadian Clock System
Confino, S., Dor, T., Wexler, Y., Livne, Z. B. M., Kolker, M., Pisanty, O., Park, S. K., Geyer, N., Reiter, J., Edvardson, S., Mor-Shaked, H., Elpeleg, O., Vallone, D., Appelbaum, L., Foulkes, N. S. & Gothilf, Y., 1 Feb 2022, In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 23, 4, 2373.Tel Aviv University, Bar-Ilan University
Research output: Contribution to journal › Article › peer-review
Open Access