Personal profile
Research interests
Background
Flagella are organelles that facilitate locomotion of single cells, such as bacteria, archaea, algae, parasites, and human sperm. These cells depend on motility to find nutrients, escape threats, and mate. Flagella structure and mechanism vary among domains (Bacteria, Archaea, Eukarya), but all are complex molecular machines that power cell motility.
Current Projects
We use methods in biochemistry and structural biology (especially cryo-EM) to decipher the structure of flagella, and thereby their beating mechanisms. We are currently focusing on flagella from haloarchaea (salt-loving extremophiles) and eukaryotic parasites, which rely on their flagella to survive.
Keywords
- Q Science (General)
- Structural Biology
- Protein complexes
- haloarchaea
- flagella
- eukaryotic parasites
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Collaborations and top research areas from the last five years
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Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite
Bose, P., Dahan, I., Upcher, A., Zalk, R. & Grossman-Haham, I., 1 May 2026, In: Protein Science. 35, 5, e70591.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Identification of the D-glucuronyl C5-epimerase that introduces iduronic acid into N-linked glycans decorating archaeal glycoproteins
Vershinin, Z., Zaretsky, M., Notaro, A., Yu, D., Molinaro, A., Sofer, S., Grossman-Haham, I., De Castro, C. & Eichler, J., 1 Dec 2025, In: Communications Biology. 8, 1, 1591.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Multiple mutations in polyketide synthase led to disruption of Psittacofulvin production across diverse parrot species
Ghosh Roy, S., Brejcha, J., Maršík, P., Bakhrat, A., Abdu, M., Arbore, R., Araújo, P. M., Afonso, S., Carneiro, M., Grossman-Haham, I. & Abdu, U., 1 Dec 2025, In: Communications Biology. 8, 1, 69.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Two different sulfotransferases modify sugars of the N-linked tetrasaccharide decorating Halobacterium salinarum glycoproteins
Zaretsky, M., Vershinin, Z., Erez, L., Grossman-Haham, I. & Eichler, J., 1 Apr 2025, In: mBio. 16, 4Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Perturbed N-glycosylation of Halobacterium salinarum archaellum filaments leads to filament bundling and compromised cell motility
Sofer, S., Vershinin, Z., Mashni, L., Zalk, R., Shahar, A., Eichler, J. & Grossman-Haham, I., 1 Dec 2024, In: Nature Communications. 15, 1, 5841.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access