Research output per year
Research output per year
Personal profile
Research interests
Background
Flagella are organelles that facilitate locomotion of single cells, such as bacteria, archaea, algae, parasites, and human sperm. These cells depend on motility to find nutrients, escape threats, and mate. Flagella structure and mechanism vary among domains (Bacteria, Archaea, Eukarya), but all are complex molecular machines that power cell motility.
Current Projects
We use methods in biochemistry and structural biology (especially cryo-EM) to decipher the structure of flagella, and thereby their beating mechanisms. We are currently focusing on flagella from haloarchaea (salt-loving extremophiles) and eukaryotic parasites, which rely on their flagella to survive.
Keywords
- Q Science (General)
- Structural Biology
- Protein complexes
- haloarchaea
- flagella
- eukaryotic parasites
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Multiple mutations in polyketide synthase led to disruption of Psittacofulvin production across diverse parrot species
Ghosh Roy, S., Brejcha, J., Maršík, P., Bakhrat, A., Abdu, M., Arbore, R., Araújo, P. M., Afonso, S., Carneiro, M., Grossman-Haham, I. & Abdu, U., 1 Dec 2025, In: Communications Biology. 8, 1, 69.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Two different sulfotransferases modify sugars of the N-linked tetrasaccharide decorating Halobacterium salinarum glycoproteins
Zaretsky, M., Vershinin, Z., Erez, L., Grossman-Haham, I. & Eichler, J., 1 Apr 2025, In: mBio. 16, 4Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Perturbed N-glycosylation of Halobacterium salinarum archaellum filaments leads to filament bundling and compromised cell motility
Sofer, S., Vershinin, Z., Mashni, L., Zalk, R., Shahar, A., Eichler, J. & Grossman-Haham, I., 1 Dec 2024, In: Nature Communications. 15, 1, 5841.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Towards an atomic model of a beating ciliary axoneme
Grossman-Haham, I., 1 Feb 2023, In: Current Opinion in Structural Biology. 78, 102516.Ben-Gurion University of the Negev
Research output: Contribution to journal › Review article › peer-review
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Structure of the radial spoke head and insights into its role in mechanoregulation of ciliary beating
Grossman-Haham, I., Coudray, N., Yu, Z., Wang, F., Zhang, N., Bhabha, G. & Vale, R. D., 1 Jan 2021, In: Nature Structural and Molecular Biology. 28, 1, p. 20-28 9 p.Research output: Contribution to journal › Article › peer-review
Open Access