Eldar-Finkelman Hagit

Research output

Research output per year 2000 2011 2013 2016 2022 2025

• 31 Article
• 5 Review article
• 1 Comment/debate
• 1 Editorial

Research output per year

Research output per year

Search results

• 2025

  Small molecule modulation of p75^NTR engages the autophagy-lysosomal pathway and reduces huntingtin aggregates in cellular and mouse models of Huntington's disease

  Simmons, D. A., Alexander, N., Cao, G., Rippin, I., Lugassy, Y., Eldar-Finkelman, H. & Longo, F. M., Mar 2025, In: Neurotherapeutics. 22, 2, e00495.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  Ataxia Telangiectasia Mutated Signaling Delays Skin Pigmentation upon UV Exposure by Mediating MITF Function toward DNA Repair Mode

  Elkoshi, N., Parikh, S., Malcov-Brog, H., Parikh, R., Manich, P., Netti, F., Maliah, A., Elkoshi, H., Haj, M., Rippin, I., Frand, J., Perluk, T., Haiat-Factor, R., Golan, T., Regev-Rudzki, N., Kiper, E., Brenner, R., Gonen, P., Dror, I., Levi, H., & 11 othersHameiri, O., Cohen-Gulkar, M., Eldar-Finkelman, H., Ast, G., Nizri, E., Ziv, Y., Elkon, R., Khaled, M., Ebenstein, Y., Shiloh, Y. & Levy, C., 1 Dec 2023, In: Journal of Investigative Dermatology. 143, 12, p. 2494-2506.e4

  Tel Aviv University, Weizmann Institute of Science

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Nonsense mutation suppression is enhanced by targeting different stages of the protein synthesis process

  Wittenstein, A., Caspi, M., Rippin, I., Elroy-Stein, O., Eldar-Finkelman, H., Thoms, S. & Rosin-Arbesfeld, R., Nov 2023, In: PLoS Biology. 21, 11 November, e3002355.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • nonsense mutation 100%
  • Nonsense Codon 81%
  • Protein Synthesis 74%
  • Mutation 60%
  • protein synthesis 53%

• Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice

  Farfara, D., Sooliman, M., Avrahami, L., Royal, T. G., Amram, S., Rozenstein-Tsalkovich, L., Trudler, D., Blanga-Kanfi, S., Eldar-Finkelman, H., Pahnke, J., Rosenmann, H. & Frenkel, D., 26 Jul 2023, In: Journal of Neuroinflammation. 20, 1, p. 174 174.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Amyloid 100%
  • Astrocytes 97%
  • Pathology 66%
  • Alzheimer Disease 46%
  • Neuroglia 26%
• 2022

  An Exercise-Induced Metabolic Shield in Distant Organs Blocks Cancer Progression and Metastatic Dissemination

  Sheinboim, D., Parikh, S., Manich, P., Markus, I., Dahan, S., Parikh, R., Stubbs, E., Cohen, G., Zemser-Werner, V., Bell, R. E., Arciniegas Ruiz, S., Percik, R., Brenner, R., Leibou, S., Vaknine, H., Arad, G., Gerber, Y., Keinan Boker, L., Shimony, T., Goldstein, N., & 21 othersBikovski, L., Constantini, K., Labes, S., Mordechai, S., Doron, H., Ionescu, A., Ziv, T., Nizri, E., Choshen, G., Eldar-Finkelman, H., Tabach, Y., Helman, A., Ben-Eliyahu, S., Erez, N., Perlson, E., Geiger, T., Ben-Zvi, D., Khaled, M., Gepner, Y., Levy, C. & Lonescu, A., 15 Nov 2022, In: Cancer Research. 82, 22, p. 4164-4178 15 p.

  Weizmann Institute of Science, Tel Aviv University, University of Haifa, Technion - Israel Institute of Technology, The Hebrew University of Jerusalem

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Exercise 100%
  • Neoplasms 49%
  • Glucose 29%
  • Proteomics 28%
  • Nutrients 26%

• GSK-3β Inhibition in Birds Affects Social Behavior and Increases Motor Activity

  Moaraf, S., Rippin, I., Terkel, J., Eldar-Finkelman, H. & Barnea, A., 28 Apr 2022, In: Frontiers in Physiology. 13, p. 881174 881174.

  Tel Aviv University, Open University of Israel

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • Social Behavior 86%
  • Birds 79%
  • Motor Activity 79%
  • Psychological Inhibition 60%
• 2021

  Inhibition of GSK-3 ameliorates the pathogenesis of Huntington's disease

  Rippin, I., Bonder, K., Joseph, S., Sarsor, A., Vaks, L. & Eldar-Finkelman, H., Jul 2021, In: Neurobiology of Disease. 154, 105336.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • Huntington Disease 82%
  • Psychological Inhibition 60%
  • Lysosomes 32%
  • Autophagy 30%
• 2020

  Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

  Rippin, I., Shirley Ben Joseph, Kudinov, T., Berent, E., Arciniegas Ruiz, S. M., Marciano, D., Gruzman, A., Senderowitz, H. & Eldar-Finkelman, H., 2 Nov 2020, In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 21, 22, p. 1-17 17 p., 8709.

  Tel Aviv University, Bar-Ilan University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Binding sites 100%
  • Glycogen Synthase Kinase 3 96%
  • inhibitors 83%
  • Threonine 80%
  • Molecules 69%

• GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways

  Avrahami, L., Paz, R., Dominko, K., Hecimovic, S., Bucci, C. & Eldar-Finkelman, H., Jul 2020, In: Cellular Signalling. 71, 109597.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • Autophagy 71%
  • Lysosomes 33%
  • Mechanistic Target of Rapamycin Complex 1 20%
  • Endosomes 18%
• 2017

  Intranasal siRNA administration reveals IGF2 deficiency contributes to impaired cognition in Fragile X syndrome mice

  Pardo, M., Cheng, Y., Velmeshev, D., Magistri, M., Eldar-Finkelman, H., Martinez, A., Faghihi, M. A., Jope, R. S. & Beurel, E., 23 Mar 2017, In: JCI Insight. 2, 6, e91782.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Fragile X Syndrome 100%
  • Intranasal Administration 97%
  • Somatomedins 81%
  • Small Interfering RNA 64%
  • Cognition 60%

• Ketamine up-regulates a cluster of intronic miRNAs within the serotonin receptor 2C gene by inhibiting glycogen synthase kinase-3

  Grieco, S. F., Velmeshev, D., Magistri, M., Eldar-Finkelman, H., Faghihi, M. A., Jope, R. S. & Beurel, E., 18 Aug 2017, In: World Journal of Biological Psychiatry. 18, 6, p. 445-456 12 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Receptor, Serotonin, 5-HT2C 100%
  • Glycogen Synthase Kinase 3 94%
  • Ketamine 76%
  • MicroRNAs 58%
  • Learned Helplessness 51%

• Up-regulation of insulin-like growth factor 2 by ketamine requires glycogen synthase kinase-3 inhibition

  Grieco, S. F., Cheng, Y., Eldar-Finkelman, H., Jope, R. S. & Beurel, E., 4 Jan 2017, In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 72, p. 49-54 6 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • Ketamine 81%
  • Somatomedins 78%
  • Learned Helplessness 62%
  • Psychological Inhibition 60%
• 2016

  A unique type of GSK-3 inhibitor brings new opportunities to the clinic

  Licht-Murava, A., Paz, R., Vaks, L., Avrahami, L., Plotkin, B., Eisenstein, M. & Eldar-Finkelman, H., 15 Nov 2016, In: Science Signaling. 9, 454, 13 p., ra110.

  Tel Aviv University, Weizmann Institute of Science

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3 Inhibitor 100%
  • Glycogen Synthase Kinase 3 73%
  • Glycogen 65%
  • Disorder 31%
  • Safety Property 29%

• Science Signaling Podcast for 15 November 2016: A new type of kinase inhibitor

  Eldar-Finkelman, H. & VanHook, A. M., 15 Nov 2016, In: Science Signaling. 9, 454, pc22.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • Webcasts 100%
  • Glycogen Synthase Kinase 3 84%
  • Phosphotransferase Inhibitor 78%
  • Glycogen 74%
  • Phosphotransferases 48%
• 2015

  Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth

  Azoulay-Alfaguter, I., Elya, R., Avrahami, L., Katz, A. & Eldar-Finkelman, H., 27 Aug 2015, In: Oncogene. 34, 35, p. 4613-4623 11 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • Autophagy 71%
  • Growth 37%
  • Neoplasms 23%
  • TOR Serine-Threonine Kinases 16%

• GSK-3β inhibition affects singing behavior and neurogenesis in adult songbirds

  Aloni, E., Shapira, M., Eldar-Finkelman, H. & Barnea, A., 13 Aug 2015, In: Brain, Behavior and Evolution. 85, 4, p. 233-244 12 p.

  Tel Aviv University, Open University of Israel

  Research output: Contribution to journal › Article › peer-review

  • Songbirds 100%
  • Singing 95%
  • Glycogen Synthase Kinase 3 94%
  • Neurogenesis 74%
  • Psychological Inhibition 57%
• 2013

  Design, synthesis, and biological evaluation of 1-phenylpyrazolo[3,4- e ]pyrrolo[3,4- G ]indolizine-4,6(1 H,5 h)-diones as new glycogen synthase kinase-3β inhibitors

  La Pietra, V., La Regina, G., Coluccia, A., Famiglini, V., Pelliccia, S., Plotkin, B., Eldar-Finkelman, H., Brancale, A., Ballatore, C., Crowe, A., Brunden, K. R., Marinelli, L., Novellino, E. & Silvestri, R., 27 Dec 2013, In: Journal of Medicinal Chemistry. 56, 24, p. 10066-10078 13 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • indolizine 100%
  • Glycogen Synthase Kinase 3 Inhibitor 90%
  • Glycogen Synthase Kinase 3 66%
  • compound 18 40%
  • Polytetrafluoroethylene 13%

• GSK-3 and lysosomes meet in Alzheimer's disease

  Avrahami, L. & Eldar-Finkelman, H., 2013, In: Communicative and Integrative Biology. 6, 5, e25179.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • tau-protein kinase 100%
  • Glycogen Synthase Kinase 3 85%
  • Alzheimer disease 78%
  • Presenilin-1 75%
  • lysosomes 65%

• Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the alzheimer disease mouse model: In vivo and in vitro studies

  Avrahami, L., Farfara, D., Shaham-Kol, M., Vassar, R., Frenkel, D. & Eldar-Finkelman, H., 11 Jan 2013, In: Journal of Biological Chemistry. 288, 2, p. 1295-1306 12 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • N-myristoyl-glycyl-lysyl-glutamyl-alanyl-prolyl-prolyl-alanyl-prolyl-prolyl-glutaminyl-phosphoseryl-proline 90%
  • Glycogen 88%
  • TOR Serine-Threonine Kinases 82%
  • Amyloid 70%

• Regulation of Th1 cells and experimental autoimmune encephalomyelitis by glycogen synthase kinase-3

  Beurel, E., Kaidanovich-Beilin, O., Yeh, W. I., Song, L., Palomo, V., Michalek, S. M., Woodgett, J. R., Harrington, L. E., Eldar-Finkelman, H., Martinez, A. & Jope, R. S., 15 May 2013, In: Journal of Immunology. 190, 10, p. 5000-5011 12 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • Autoimmune Experimental Encephalomyelitis 86%
  • Th1 Cells 85%
  • Th17 Cells 43%
  • N-myristoyl-glycyl-lysyl-glutamyl-alanyl-prolyl-prolyl-alanyl-prolyl-prolyl-glutaminyl-phosphoseryl-proline 40%

• Structure-based optimization of oxadiazole-based GSK-3 inhibitors

  Lo Monte, F., Kramer, T., Gu, J., Brodrecht, M., Pilakowski, J., Fuertes, A., Dominguez, J. M., Plotkin, B., Eldar-Finkelman, H. & Schmidt, B., Mar 2013, In: European Journal of Medicinal Chemistry. 61, p. 26-40 15 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3 Inhibitor 100%
  • Oxadiazoles 90%
  • Glycogen Synthase Kinase 3 73%
  • Glycogen 65%
  • Neuroprotective 8%
• 2012

  Exploiting substrate recognition for selective inhibition of protein kinases

  Licht-Murava, A. & Eldar-Finkelman, H., Jul 2012, In: Current Pharmaceutical Design. 18, 20, p. 2914-2920 7 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • Protein Kinases 100%
  • Protein Kinase Inhibitor 53%
  • Glycogen Synthase Kinase 3 48%
  • Protein 44%
  • Glycogen 43%

• Identification of glycogen synthase kinase-3 inhibitors with a selective sting for glycogen synthase kinase-α

  Lo Monte, F., Kramer, T., Gu, J., Anumala, U. R., Marinelli, L., La Pietra, V., Novellino, E., Franco, B., Demedts, D., Van Leuven, F., Fuertes, A., Dominguez, J. M., Plotkin, B., Eldar-Finkelman, H. & Schmidt, B., 10 May 2012, In: Journal of Medicinal Chemistry. 55, 9, p. 4407-4424 18 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3 Inhibitor 100%
  • Glycogen Synthase Kinase 3 73%
  • Glycogen Synthase Kinases 69%
  • Glycogen 65%
  • Bites and Stings 59%
• 2011

  Distinct molecular regulation of glycogen synthase kinase-3α isozyme controlled by its N-terminal region functional role in CALCIUM/CALPAIN signaling

  Azoulay-Alfaguter, I., Yaffe, Y., Licht-Murava, A., Urbanska, M., Jaworsk, J., Pietrokovski, S., Hirschberg, K. & Eldar-Finkelman, H., 15 Apr 2011, In: Journal of Biological Chemistry. 286, 15, p. 13470-13480 11 p.

  Tel Aviv University, Weizmann Institute of Science

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • Glycogen 88%
  • Isoenzymes 74%
  • Calcium 11%
  • Catenins 10%

• Elucidating substrate and inhibitor binding sites on the surface of GSK-3β and the refinement of a competitive inhibitor

  Licht-Murava, A., Plotkin, B., Eisenstein, M. & Eldar-Finkelman, H., 29 Apr 2011, In: Journal of Molecular Biology. 408, 2, p. 366-378 13 p.

  Tel Aviv University, Weizmann Institute of Science

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3 100%
  • Binding Sites 57%
  • N-myristoyl-glycyl-lysyl-glutamyl-alanyl-prolyl-prolyl-alanyl-prolyl-prolyl-glutaminyl-phosphoseryl-proline 20%
  • Hydrophobic and Hydrophilic Interactions 10%
  • Protein Kinases 8%

• Exploiting substrate recognition for selective inhibition of protein kinases

  Licht-Murava, A. & Eldar-Finkelman, H., Jun 2011, In: Bio Tech International. 23, JUNE, p. 23-25 3 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • Protein Kinases 100%
  • Glycogen Synthase Kinase 3 48%
  • Protein Kinase Inhibitors 38%
  • Drug Discovery 37%
  • Adenosine Triphosphate 28%

• GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

  Eldar-Finkelman, H. & Martinez, A., 2011, In: Frontiers in Molecular Neuroscience. 4, p. 32

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3 100%
  • Drug Design 21%
  • Neuropathology 20%
  • Central Nervous System Diseases 20%
  • Cations 18%

• Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

  Alon, L. T., Pietrokovski, S., Barkan, S., Avrahami, L., Kaidanovich-Beilin, O., Woodgett, J. R., Barnea, A. & Eldar-Finkelman, H., 20 Apr 2011, In: FEBS Letters. 585, 8, p. 1158-1162 5 p.

  Open University of Israel, Tel Aviv University, Weizmann Institute of Science

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Glycogen Synthase Kinase 3 100%
  • Glycogen 88%
  • Birds 79%
  • Isoenzymes 74%
  • Phosphorylation 51%

• Synthesis and biological evaluation of glycogen synthase kinase 3 (GSK-3) inhibitors: An fast and atom efficient access to 1-aryl-3-benzylureas

  Monte, F. L., Kramer, T., Boländer, A., Plotkin, B., Eldar-Finkelman, H., Fuertes, A., Dominguez, J. & Schmidt, B., 15 Sep 2011, In: Bioorganic and Medicinal Chemistry Letters. 21, 18, p. 5610-5615 6 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  • Glycogen Synthase Kinase 3 Inhibitor 100%
  • Glycogen Synthase Kinase 3 73%
  • N-(4-methoxybenzyl)-N'-(5-nitro-1,3-thiazol-2-yl)urea 70%
  • IC 140 43%
  • Glycogen 32%

• Wnt signaling pathway overcomes the disruption of neuronal differentiation of neural progenitor cells induced by oligomeric amyloid β-peptide

  Shruster, A., Eldar-Finkelman, H., Melamed, E. & Offen, D., Feb 2011, In: Journal of Neurochemistry. 116, 4, p. 522-529 8 p.

  Tel Aviv University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Wnt Signaling Pathway 100%
  • Amyloid 83%
  • Stem Cells 64%
  • Peptides 56%
  • Neurogenesis 46%
• 2000

  Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes

  Zhao, A. Z., Shinohara, M. M., Huang, D., Shimizu, M., Eldar-Finkelman, H., Krebs, E. G., Beavo, J. A. & Bornfeldt, K. E., 14 Apr 2000, In: Journal of Biological Chemistry. 275, 15, p. 11348-11354 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Leptin 100%
  • Glucagon 79%
  • Hepatocytes 49%
  • Phosphatidylinositol 40%
  • Insulin 39%