Research output per year
Research output per year
Personal profile
Research interests
- Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
- Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
- Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g. brain endothelial cells, pericytes, astrocytes and neurons.
- Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
- Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).
Research interests
- Our research aims to understand the mechanisms that underlie neurological disorders and develop personalized therapeutic approaches for patients. We use patient-specific stem cells to recreate diseases in a dish. Our main interest is to study the role of the blood brain barrier (BBB) in neurological disorders.
Research interests
- Developing stem-cell (iPSC) based personalized platforms of the human BBB in order to study diversity in brain penetrability among individuals.
- Elucidating the role of the BBB in neurological disease using patient-specific stem cells (iPSCs).
- Studying cell-to-cell interactions between the various cells of the neurovascular unit (NVU) e.g.brain endothelial cells, pericytes, astrocytes and neurons.-----
- Studying the mechanisms underlying leukodystrophys (diseases of the white matter), and development of translational cell-therapy approaches.
- Pre-clinical development of translational strategies for BBB-targeted gene therapy, to treat the Allan Herndon Dudley syndrome (AHDS, also known as MCT8-deficiency).
Fingerprint
Dive into the research topics where Gad Vatine is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
Membrane Permeability Monitoring to Antipsychotic Olanzapine Using Platinum Black-Modified Electrodes
Ilango, M. S., Desagani, D., Jagadeesan, S., Snezhko, A., Vatine, G. & Ben-Yoav, H., 1 Apr 2025, In: Sensors. 25, 7, 2266.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Proteomic analysis of human iPSC-derived sympathetic neurons identifies proteostasis collapse as a molecular signature following subtoxic rotenone exposure
Gordon, T., Saleh, M. A., Pasmanik-Chor, M., Vatine, G. D. & Ashkenazi, A., 1 Jan 2025, In: Toxicology. 510, 154015.Tel Aviv University, Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
-
Chronic and acute exposure to rotenone reveals distinct Parkinson's disease-related phenotypes in human iPSC-derived peripheral neurons
Saleh, M. A., Amer-Sarsour, F., Berant, A., Pasmanik-Chor, M., Kobo, H., Sharabi, Y., Vatine, G. D. & Ashkenazi, A., 1 Mar 2024, In: Free Radical Biology and Medicine. 213, p. 164-173 10 p.Tel Aviv University, Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access -
Disease-associated polyalanine expansion mutations impair UBA6-dependent ubiquitination
Amer-Sarsour, F., Falik, D., Berdichevsky, Y., Kordonsky, A., Eid, S., Rabinski, T., Ishtayeh, H., Cohen-Adiv, S., Braverman, I., Blumen, S. C., Laviv, T., Prag, G., Vatine, G. D. & Ashkenazi, A., 16 Jan 2024, In: EMBO Journal. 43, 2, p. 250-276 27 p.Tel Aviv University, Ben-Gurion University of the Negev, Technion - Israel Institute of Technology
Research output: Contribution to journal › Article › peer-review
Open Access -
Impedance Characteristics of Microfluidic Channels and Integrated Coplanar Parallel Electrodes as Design Parameters for Whole-Channel Analysis in Organ-on-Chip Micro-Systems
Rapier, C. E., Jagadeesan, S., Vatine, G. D. & Ben-Yoav, H., 1 Aug 2024, In: Biosensors. 14, 8, 374.Ben-Gurion University of the Negev
Research output: Contribution to journal › Article › peer-review
Open Access