Toiber Debbie

Research output

Research output per year 2011 2017 2021 2023

• 23 Article
• 2 Comment/debate
• 1 Chapter
• 1 Abstract
• 4 More
  • 1 Meeting Abstract
  • 1 Editorial
  • 1 Other contribution
  • 1 Preprint

Research output per year

Research output per year

Search results

• 2023

  SIRT6 is a key regulator of mitochondrial function in the brain

  Smirnov, D., Eremenko, E., Stein, D., Kaluski, S., Jasinska, W., Cosentino, C., Martinez-Pastor, B., Brotman, Y., Mostoslavsky, R., Khrameeva, E. & Toiber, D., 1 Jan 2023, In: Cell Death and Disease. 14, 1, 35.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain 100%
  • Mitochondrial Genes 64%
  • Metabolomics 56%
  • Gene Expression 45%
  • YY1 Transcription Factor 42%
• 2022

  4-phenylbutyric acid—Identity crisis; can it act as a translation inhibitor?

  Stein, D., Slobodnik, Z., Tam, B., Einav, M., Akabayov, B., Berstein, S. & Toiber, D., 1 Dec 2022, In: Aging Cell. 21, 12, e13738.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 4-phenylbutyric acid 100%
  • Proteostasis 41%
  • Protein Folding 37%
  • Endoplasmic Reticulum Stress 35%
  • Protein Biosynthesis 34%
• 2021

  Aging and pathological aging signatures of the brain: through the focusing lens of SIRT6

  Stein, D., Mizrahi, A., Golova, A., Saretzky, A., Venzor, A. G., Slobodnik, Z., Kaluski, S., Einav, M., Khrameeva, E. & Toiber, D., 15 Mar 2021, In: Aging. 13, 5, p. 6420-6441 22 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lenses 100%
  • Healthy Aging 52%
  • Brain 51%
  • Transcriptome 38%
  • Gene Expression 37%

• A Mechanism for the Inhibition of Tau Neurotoxicity: Studies with Artificial Membranes, Isolated Mitochondria, and Intact Cells

  Naveh Tassa, S., Ben Zichri, S., Lacham-Hartman, S., Oren, O., Slobodnik, Z., Eremenko, E., Toiber, D., Jelinek, R. & Papo, N., 5 May 2021, In: ACS Chemical Neuroscience. 12, 9, p. 1563-1577 15 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  • Artificial Membranes 100%
  • Neurotoxicity 84%
  • Mitochondria 55%
  • Psychological Inhibition 55%
  • Mitochondrial Membranes 45%

• FACS-based isolation of fixed mouse neuronal nuclei for ATAC-seq and Hi-C

  Eremenko, E., Golova, A., Stein, D., Einav, M., Khrameeva, E. & Toiber, D., 17 Sep 2021, In: STAR Protocols. 2, 3, 100643.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transposases 100%
  • Chromatin 62%
  • Modification 39%
  • Gene Expression 16%
  • Genomic Instability 15%

• Metabolic Imbalance Effect on Retinal Müller Glial Cells Reprogramming Capacity: Involvement of Histone Deacetylase SIRT6

  Sanhueza Salas, L. F., García-Venzor, A., Beltramone, N., Capurro, C., Toiber, D. & Silberman, D. M., 4 Nov 2021, In: Frontiers in Genetics. 12, 769723.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Cellular Reprogramming 100%
  • Histone Deacetylases 91%
  • Neuroglia 69%
  • Glucose 49%
  • Cell Movement 25%

• SIRT6-CBP-dependent nuclear Tau accumulation and its role in protein synthesis

  Portillo, M., Eremenko, E., Kaluski, S., Garcia-Venzor, A., Onn, L., Stein, D., Slobodnik, Z., Zaretsky, A., Ueberham, U., Einav, M., Brückner, M. K., Arendt, T. & Toiber, D., 27 Apr 2021, In: Cell Reports. 35, 4, 109035.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Protein Synthesis 100%
  • Acetylation 96%
  • Marker 84%
  • DNA Damage 83%
  • Alzheimer Disease 74%

• SIRT6 Through the Brain Evolution, Development, and Aging

  Garcia-Venzor, A. & Toiber, D., 13 Oct 2021, In: Frontiers in Aging Neuroscience. 13, 747989.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Brain 100%
  • Embryonic Development 26%
  • Group III Histone Deacetylases 26%
  • Neurodegenerative Diseases 25%
  • Survival 24%

• The 2021 FASEB science research conference on NAD metabolism and signaling

  Gorbunova, V., Buschbeck, M., Cambronne, X. A., Chellappa, K., Corda, D., Du, J., Freichel, M., Gigas, J., Green, A. E., Gu, F., Guberovic, I., Jayabalan, A., Khansahib, I., Mukherjee, S., Seluanov, A., Simon, M. A., Sverkeli, L. J., Kory, N., Levine, D. C., Matic, I., & 9 othersNikiforov, A., Rack, J. G. M., Imai, S. I., Sinclair, D. A., Toiber, D., Zhao, Y., Mostoslavsky, R., Kraus, L. & Guse, A. H., 1 Jan 2021, In: Aging. 13, 23, p. 24924-24930 7 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Tp73-As1 Is Induced By Yy1 During Tmz Treatment And Highly Expressed In The Aging Brain

  Mazor, G., Smirnov, D., David, H. B., Khrameeva, E., Toiber, D. & Rotblat, B., 15 Jun 2021, In: Aging. 13, 11, p. 14843-14861 19 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs

  Jayaram, D. R., Frost, S., Argov, C., Liju, V. B., Anto, N. P., Muraleedharan, A., Ben-Ari, A., Sinay, R., Smoly, I., Novoplansky, O., Isakov, N., Toiber, D., Keasar, C., Elkabets, M., Yeger-Lotem, E. & Livneh, E., 5 Oct 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 40, e2018899118.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Open Reading Frames 100%
  • Phosphotransferases 80%
  • Peptides 66%
  • protein kinase C eta 46%
  • Breast Neoplasms 24%
• 2020

  ARDD 2020: from aging mechanisms to interventions

  Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J., & 46 othersGorbunova, V., Grey, A. D., He, W. W., Hoeijmakers, J., Hoffmann, E., Horvath, S., Houtkooper, R. H., Jensen, M. K., Jensen, M. B., Kane, A., Kassem, M., Keizer, P. D., Kennedy, B., Karsenty, G., Lamming, D. W., Lee, K. F., MacAulay, N., Mamoshina, P., Mellon, J., Molenaars, M., Moskalev, A., Mund, A., Niedernhofer, L., Osborne, B., Pak, H. H., Parkhitko, A., Raimundo, N., Rando, T. A., Rasmussen, L. J., Reis, C., Riedel, C. G., Franco-Romero, A., Schumacher, B., Sinclair, D. A., Suh, Y., Taub, P. R., Toiber, D., Treebak, J. T., Valenzano, D. R., Verdin, E., Vijg, J., Young, S., Zhang, L., Bakula, D., Zhavoronkov, A. & Scheibye-Knudsen, M., 31 Dec 2020, In: Aging. 12, 24, p. 24486-24503 18 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Drug Discovery 100%
  • Industry 59%
  • Calendars 43%
  • Artificial Intelligence 42%
  • Longevity 29%

• Molecular Mechanism of Nuclear Tau Accumulation and its Role in Protein Synthesis

  Portillo, M., Eremenko, E., Kaluski, S., Onn, L., Stein, D., Slobodnik, Z., Ueberham, U., Einav, M., Brückner, M. K., Arendt, T. & Toiber, D., 1 Sep 2020.

  Ben-Gurion University of the Negev

  Research output: Working paper › Preprint

  • DNA Damage 100%
  • Protein Biosynthesis 83%
  • Acetylation 80%
  • nucleolin 58%
  • Proteins 56%

• SIRT6 is a DNA double-strand break sensor

  Onn, L., Portillo, M., Ilic, S., Cleitman, G., Stein, D., Kaluski, S., Shirat, I., Slobodnik, Z., Einav, M., Erdel, F., Akabayov, B. & Toiber, D., 1 Jan 2020, In: eLife. 9, e51636.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Double-Stranded DNA Breaks 100%
  • DNA Damage 76%
  • 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione 42%
  • Protein 36%
  • Sirtuins 19%
• 2019

  Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

  Lan, A., Stein, D., Portillo, M., Toiber, D. & Kofman, O., 1 Mar 2019, In: Behavioral and Brain Functions. 15, 1, 2.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Chlorpyrifos 100%
  • Social Behavior 79%
  • Oxytocin 31%
  • Hypothalamus 27%
  • Corn Oil 12%
• 2018

  Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance

  Gertman, O., Omer, D., Hendler, A., Stein, D., Onn, L., Khukhin, Y., Portillo, M., Zarivach, R., Cohen, H. Y., Toiber, D. & Aharoni, A., 1 Dec 2018, In: Scientific Reports. 8, 1, 3538.

  Ben-Gurion University of the Negev, Bar-Ilan University

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Homeostasis 100%
  • Maintenance 95%
  • Glucose 85%
  • Histone Deacetylases 52%
  • Proteins 50%

• Epigenetic control of early neurodegenerative events in diabetic retinopathy by the histone deacetylase SIRT6

  Zorrilla-Zubilete, M. A., Yeste, A., Quintana, F. J., Toiber, D., Mostoslavsky, R. & Silberman, D. M., 1 Jan 2018, In: Journal of Neurochemistry. 144, 2, p. 128-138 11 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Deacetylases 100%
  • Histone 91%
  • Diabetic Retinopathy 89%
  • Epigenomics 74%
  • Retinal 73%
• 2017

  Corrigendum: Long noncoding RNA: Noncoding and not coded(Cell death discovery (2017) 3, (16104) 10.1038/cddiscovery.2016.104)

  Toiber, D., Leprivier, G. & Rotblat, B., 1 Jan 2017, In: Cell Death Discovery. 3, 17035.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Comment/debate

  Open Access

  • Medical Faculties 100%
  • Medical Oncology 90%
  • Long Noncoding RNA 82%
  • Hematology 81%
  • Allergy and Immunology 81%

• DNA damage and neurodegeneration: The unusual suspect

  Stein, D. & Toiber, D., 1 Sep 2017, In: Neural Regeneration Research. 12, 9, p. 1441-1442 2 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Comment/debate

  Open Access

• Long noncoding RNA: Noncoding and not coded

  Toiber, D., Leprivier, G. & Rotblat, B., 1 Jan 2017, In: Cell Death Discovery. 3, 16104.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Editorial

  Open Access

• Neuroprotective Functions for the Histone Deacetylase SIRT6

  Kaluski, S., Portillo, M., Besnard, A., Stein, D., Einav, M., Zhong, L., Ueberham, U., Arendt, T., Mostoslavsky, R., Sahay, A. & Toiber, D., 28 Mar 2017, In: Cell Reports. 18, 13, p. 3052-3062 11 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neuroprotective 100%
  • Histone Deacetylases 91%
  • Histone 84%
  • DNA Damage 45%
  • Cell Death 41%

• Short versus long double-stranded RNA activation of a post-transcriptional gene knockdown pathway

  Shpak, N., Manor, R., Abilevich, L. K., Mantal, O., Shavit, K., Aflalo, E. D., Toiber, D. & Sagi, A., 2 Dec 2017, In: RNA Biology. 14, 12, p. 1766-1775 10 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Double-Stranded RNA 100%
  • Gene Knockdown Techniques 91%
  • double-stranded RNA 76%
  • gene targeting 74%
  • RNA Interference 67%

• TOX regulates growth, DNA repair, and genomic instability in T-cell acute lymphoblastic leukemia

  Lobbardi, R., Pinder, J., Martinez-Pastor, B., Theodorou, M., Blackburn, J. S., Abraham, B. J., Namiki, Y., Mansour, M., Abdelfattah, N. S., Molodtsov, A., Alexe, G., Toiber, D., De Waard, M., Jain, E., Boukhali, M., Lion, M., Bhere, D., Shah, K., Gutierrez, A., Stegmaier, K., & 10 othersSilverman, L. B., Sadreyev, R. I., Asara, J. M., Oettinger, M. A., Haas, W., Look, A. T., Young, R. A., Mostoslavsky, R., Dellaire, G. & Langenau, D. M., 1 Nov 2017, In: Cancer Discovery. 7, 11, p. 1336-1353 18 p.

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 100%
  • Genomic Instability 83%
  • DNA Repair 70%
  • Growth 38%
  • DNA Breaks 37%
• 2016

  Thymocyte selection-associated HMG box protein (TOX) induces genomic instability in T-cell acute lymphoblastic leukemia

  Lobbardi, R., Pinder, J., Martinez-Pastor, B., Blackburn, J., Abraham, B. J., Mansour, M., Abdelfattah, N. S., Molodtsov, A., Alexe, G. & Toiber, D., 2016.

  Ben-Gurion University of the Negev

  Research output: Contribution to conference › Abstract
• 2014

  A large-scale transgenic screen in zebrafish identifies TOX as a novel oncogene in T -cell acute lymphoblastic leukemia

  Lobbardi, R., Abdelfattah, N., Martinez, B., Pinder, J., Toiber, D., Blackburn, J. S., De Waard, M., Dellaire, G., Mostoslaysky, R. & Langenau, D. M., Oct 2014, In: Cancer Research. 74, 20

  Ben-Gurion University of the Negev

  Research output: Contribution to journal › Meeting Abstract › peer-review

• Thymocyte Selection-Associated High-Mobility Group Box Protein (TOX) Induces Genomic Instability in T-Cell Acute Lymphoblastic Leukemia

  Lobbardi, R., Pinder, J., Martinez-Pastor, B., Blackburn, J. S., Abdelfattah, N., Toiber, D., De Waard, M., Asara, J. M., Mostoslavsky, R. & Dellaire, G., 2014

  Ben-Gurion University of the Negev

  Research output: Other contribution
• 2013

  SIRT6 Recruits SNF2H to DNA Break Sites, Preventing Genomic Instability Through Chromatin Remodeling

  Toiber, D., Erdel, F., Bouazoune, K., Silberman, D. M., Zhong, L., Mulligan, P., Sebastian, C., Cosentino, C., Martinez-Pastor, B., Giacosa, S., D'Urso, A., Näär, A. M., Kingston, R., Rippe, K. & Mostoslavsky, R., 22 Aug 2013, In: Molecular Cell. 51, 4, p. 454-468 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sirtuins 100%
  • DNA Breaks 90%
  • Chromatin Assembly and Disassembly 86%
  • Genomic Instability 81%
  • Chromatin 65%
• 2012

  The histone deacetylase SIRT6 Is a tumor suppressor that controls cancer metabolism

  Sebastián, C., Zwaans, B. M. M., Silberman, D. M., Gymrek, M., Goren, A., Zhong, L., Ram, O., Truelove, J., Guimaraes, A. R., Toiber, D., Cosentino, C., Greenson, J. K., MacDonald, A. I., McGlynn, L., Maxwell, F., Edwards, J., Giacosa, S., Guccione, E., Weissleder, R., Bernstein, B. E., & 4 othersRegev, A., Shiels, P. G., Lombard, D. B. & Mostoslavsky, R., 7 Dec 2012, In: Cell. 151, 6, p. 1185-1199 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Histone Deacetylases 100%
  • Histone 91%
  • Pharmacological Metabolism 66%
  • Neoplasms 27%
  • Glycolysis 16%
• 2011

  A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development

  Mulligan, P., Yang, F., Di Stefano, L., Ji, J. Y., Ouyang, J., Nishikawa, J. L., Toiber, D., Kulkarni, M., Wang, Q., Najafi-Shoushtari, S. H., Mostoslavsky, R., Gygi, S. P., Gill, G., Dyson, N. J. & Näär, A. M., 10 Jun 2011, In: Molecular Cell. 42, 5, p. 689-699 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Co-Repressor Proteins 100%
  • Histones 48%
  • Drosophila 48%
  • Gene Expression 46%
  • Epigenomics 45%

• Characterization of nuclear sirtuins: Molecular mechanisms and physiological relevance

  Toiber, D., Sebastian, C. & Mostoslavsky, R., 24 Oct 2011, Histone Deacetylases: the Biology and Clinical Implication. Yao, T-P. & Seto, E. (eds.). p. 189-224 36 p. (Handbook of Experimental Pharmacology; vol. 206).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Sirtuins 100%
  • NAD 50%
  • Biological Role 45%
  • Lethal 44%
  • Mammals 43%

• Sirt1 is a regulator of bone mass and a repressor of sost encoding for sclerostin, a bone formation inhibitor

  Cohen-Kfir, E., Artsi, H., Levin, A., Abramowitz, E., Bajayo, A., Gurt, I., Zhong, L., D'Urso, A., Toiber, D., Mostoslavsky, R. & Dresner-Pollak, R., 1 Dec 2011, In: Endocrinology. 152, 12, p. 4514-4524 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sirtuin 1 100%
  • Osteogenesis 65%
  • Bone and Bones 44%
  • Osteoporosis 14%
  • 129 Strain Mouse 12%