Barak Rotblat

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Rotblat Barak

Ben-Gurion University of the Negev

 https://orcid.org/0000-0003-2985-7115
    20112024

    Research activity per year

    Personal profile

    Research interests

    Background

    Previously depicted as the ‘dark matter of the genome’, it is becoming clearer that genes encoding long noncoding RNAs (lncRNA) are important players in all aspects of cell biology. LncRNAs are expressed in a tissue specific manner during development, have evolved in complex organisms and, surprisingly, are found in polysomes. What do these lncRNAs do? They bind proteins and regulate their activity (they do other things as well). While there are more than 10,000 different lncRNAs, only ~ 100 lncRNAs have been characterized to date and elucidating the functions these non coding RNAs have evolved to fulfil is our challenge.

    Current Projects

    1. We are studying lncRNAs that are important in brain cancer, glioblastoma, in general and in particular in glioblastoma cancer stem cells. 2. We are interested in how protein synthesis is regulated in the cells. We aim to learn more about the functions of lncRNAs in basic cell biology processes, in particular in regulation of protein translation. In cells, there is tight regulation of which RNAs will actually be translated. This is observed as specific RNAs partition between polysomal (translated) and non-polysomal (untranslated) fractions in resting and in stimulated conditions. We observed that lncRNA behave in a similar manner to coding mRNAs and we aim to elucidate their contribution to the translational landscape of the cell.

    Expertise related to UN Sustainable Development Goals

    In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):

    • SDG 3 - Good Health and Well-being

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    • Brillouin gain microscopy

      Shaashoua, R., Kasuker, L., Kishner, M., Levy, T., Rotblat, B., Ben-Zvi, A. & Bilenca, A., 1 Aug 2024, In: Nature Photonics. 18, 8, p. 836-841 6 p.

      Ben-Gurion University of the Negev

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Enhancing Mechanical Stimulated Brillouin Scattering Imaging with Physics-Driven Model Selection

      Shaashoua, R., Levy, T., Rotblat, B. & Bilenca, A., 1 Jun 2024, In: Laser and Photonics Reviews. 18, 6, 2301054.

      Ben-Gurion University of the Negev

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • mTORC1 regulates cell survival under glucose starvation through 4EBP1/2-mediated translational reprogramming of fatty acid metabolism

      Levy, T., Voeltzke, K., Hruby, L., Alasad, K., Bas, Z., Snaebjörnsson, M., Marciano, R., Scharov, K., Planque, M., Vriens, K., Christen, S., Funk, C. M., Hassiepen, C., Kahler, A., Heider, B., Picard, D., Lim, J. K. M., Stefanski, A., Bendrin, K. & Vargas-Toscano, A. & 11 others, Kahlert, U. D., Stühler, K., Remke, M., Elkabets, M., Grünewald, T. G. P., Reichert, A. S., Fendt, S. M., Schulze, A., Reifenberger, G., Rotblat, B. & Leprivier, G., 14 May 2024, In: Nature Communications. 15, 1, 4083.

      Ben-Gurion University of the Negev

      Research output: Contribution to journal › Article › peer-review

      Open Access

    • Apoptotic cell death in disease—Current understanding of the NCCD 2023

      Vitale, I., Pietrocola, F., Guilbaud, E., Aaronson, S. A., Abrams, J. M., Adam, D., Agostini, M., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., Aqeilan, R. I., Arama, E., Baehrecke, E. H., Balachandran, S., Bano, D., Barlev, N. A., Bartek, J. & Bazan, N. G. & 208 others, Becker, C., Bernassola, F., Bertrand, M. J. M., Bianchi, M. E., Blagosklonny, M. V., Blander, J. M., Blandino, G., Blomgren, K., Borner, C., Bortner, C. D., Bove, P., Boya, P., Brenner, C., Broz, P., Brunner, T., Damgaard, R. B., Calin, G. A., Campanella, M., Candi, E., Carbone, M., Carmona-Gutierrez, D., Cecconi, F., Chan, F. K. M., Chen, G. Q., Chen, Q., Chen, Y. H., Cheng, E. H., Chipuk, J. E., Cidlowski, J. A., Ciechanover, A., Ciliberto, G., Conrad, M., Cubillos-Ruiz, J. R., Czabotar, P. E., D’Angiolella, V., Daugaard, M., Dawson, T. M., Dawson, V. L., De Maria, R., De Strooper, B., Debatin, K. M., Deberardinis, R. J., Degterev, A., Del Sal, G., Deshmukh, M., Di Virgilio, F., Diederich, M., Dixon, S. J., Dynlacht, B. D., El-Deiry, W. S., Elrod, J. W., Engeland, K., Fimia, G. M., Galassi, C., Ganini, C., Garcia-Saez, A. J., Garg, A. D., Garrido, C., Gavathiotis, E., Gerlic, M., Ghosh, S., Green, D. R., Greene, L. A., Gronemeyer, H., Häcker, G., Hajnóczky, G., Hardwick, J. M., Haupt, Y., He, S., Heery, D. M., Hengartner, M. O., Hetz, C., Hildeman, D. A., Ichijo, H., Inoue, S., Jäättelä, M., Janic, A., Joseph, B., Jost, P. J., Kanneganti, T. D., Karin, M., Kashkar, H., Kaufmann, T., Kelly, G. L., Kepp, O., Kimchi, A., Kitsis, R. N., Klionsky, D. J., Kluck, R., Krysko, D. V., Kulms, D., Kumar, S., Lavandero, S., Lavrik, I. N., Lemasters, J. J., Liccardi, G., Linkermann, A., Lipton, S. A., Lockshin, R. A., López-Otín, C., Luedde, T., MacFarlane, M., Madeo, F., Malorni, W., Manic, G., Mantovani, R., Marchi, S., Marine, J. C., Martin, S. J., Martinou, J. C., Mastroberardino, P. G., Medema, J. P., Mehlen, P., Meier, P., Melino, G., Melino, S., Miao, E. A., Moll, U. M., Muñoz-Pinedo, C., Murphy, D. J., Niklison-Chirou, M. V., Novelli, F., Núñez, G., Oberst, A., Ofengeim, D., Opferman, J. T., Oren, M., Pagano, M., Panaretakis, T., Pasparakis, M., Penninger, J. M., Pentimalli, F., Pereira, D. M., Pervaiz, S., Peter, M. E., Pinton, P., Porta, G., Prehn, J. H. M., Puthalakath, H., Rabinovich, G. A., Rajalingam, K., Ravichandran, K. S., Rehm, M., Ricci, J. E., Rizzuto, R., Robinson, N., Rodrigues, C. M. P., Rotblat, B., Rothlin, C. V., Rubinsztein, D. C., Rudel, T., Rufini, A., Ryan, K. M., Sarosiek, K. A., Sawa, A., Sayan, E., Schroder, K., Scorrano, L., Sesti, F., Shao, F., Shi, Y., Sica, G. S., Silke, J., Simon, H. U., Sistigu, A., Stephanou, A., Stockwell, B. R., Strapazzon, F., Strasser, A., Sun, L., Sun, E., Sun, Q., Szabadkai, G., Tait, S. W. G., Tang, D., Tavernarakis, N., Troy, C. M., Turk, B., Urbano, N., Vandenabeele, P., Vanden Berghe, T., Vander Heiden, M. G., Vanderluit, J. L., Verkhratsky, A., Villunger, A., von Karstedt, S., Voss, A. K., Vousden, K. H., Vucic, D., Vuri, D., Wagner, E. F., Walczak, H., Wallach, D., Wang, R., Wang, Y., Weber, A., Wood, W., Yamazaki, T., Yang, H. T., Zakeri, Z., Zawacka-Pankau, J. E., Zhang, L., Zhang, H., Zhivotovsky, B., Zhou, W., Piacentini, M., Kroemer, G. & Galluzzi, L., 1 May 2023, In: Cell Death and Differentiation. 30, 5, p. 1097-1154 58 p.

      Ben-Gurion University of the Negev, Technion - Israel Institute of Technology, Tel Aviv University, Weizmann Institute of Science, The Hebrew University of Jerusalem

      Research output: Contribution to journal › Review article › peer-review

      Open Access

    • Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness

      Galai, G., He, X., Rotblat, B. & Pilosof, S., 1 Dec 2023, In: Nature Communications. 14, 1, 6277.

      Ben-Gurion University of the Negev

      Research output: Contribution to journal › Article › peer-review

      Open Access
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